CAS: 1722-10-7; 3-Chloro-6-Methoxypyridazine

该化合物是一种环环环的环状七环有机化合物,是一种六人组成的芳香环,在1号位置和2号位置上含有两个氮原子. 3号位置上存在氯原子,6号位置上存在一种氯原子(OCH3),6号位置上存在一种甲氧原子组(OCH3),有助于其独特的化学特性.该化合物一般没有色素,可粉黄固体,其分子结构允许各种化学反应,包括核生殖器替代和电阴性替代.有机溶剂中存在溶解,因此在各种化学合成和应用中有用.氯和甲氧氧基组的存在可影响其活性和与其他物质的相互作用,使其在医药和农用化学品等领域感兴趣.此外,该化合物可能展示生物活动,但具体应用将取决于对其特性和潜在用途的进一步研究.应参考安全数据,以便处理和储存,如任何化学物质一样.

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17321-20-9 3184-71-2 1084812-45-2

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上下游产品

3,6-dichlorpyridazine sodium methylate 3-methoxypyridazine 1-oxide chloroform 3-methoxy-6-phenoxy-pyridazine 6-methoxy-3-(phenylsulfanyl)pyridazine 6-Chlor-3-methoxy-pyridazin-1-oxid 3-methoxypyridazine

合成工艺路线路线简述

    📜3-甲氧基嘧啶置于双氧水,溶剂黄146,三氯氧磷体系中,化学反应生成3-氯-6-甲氧基哒嗪
    参考文献:Igeta,Chemical And Pharmaceutical Bulletin,1959,Vol. 7,P. 938,940
    标题:Igeta,Chemical And Pharmaceutical Bulletin,1959,Vol. 7,P. 938,940

    海关参考信息

    专利信息


    专利号:FR-2692576-A1
    优先权日:1992-06-23
    标题 :Pyridazines, their synthesis and their application to the synthesis of minaprine and minaprine derivatives.

    专利号:EP-1491540-B1
    优先权日:2001-03-30
    标题 :Intermediates useful for the synthesis of pyridazinone aldose reductase inhibitors

    专利号:ES-2274369-T3
    优先权日:2001-03-30
    标 题:USEFUL INTERMEDIATES FOR SYNTHESIS OF PIRIDAZINONAS INHIBIDORAS OF ALDOSA REDUCTASA.

    专利号:US-8178559-B2
    优先权日:2004-12-30
    标 题:Organic compounds
    发明人:BREITENSTEIN WERNER; EHARA TAKERU; EHRHARDT CLAUS; GROSCHE PHILIPP; HITOMI YUKO; IWAKI YUKI; KANAZAWA TAKANORI; KONISHI KAZUHIDE; MAIBAUM JUERGEN KLAUS; MASUYA KEIICHI; IWASAKI ATSUKO; OSTERMANN NILS; SUZUKI MASAKI; TOYAO ATSUSHI; YOKOKAWA FUMIAKI
    权利人:BREITENSTEIN WERNER; EHARA TAKERU; EHRHARDT CLAUS; GROSCHE PHILIPP; HITOMI YUKO; IWAKI YUKI; KANAZAWA TAKANORI; KONISHI KAZUHIDE; MAIBAUM JUERGEN KLAUS; MASUYA KEIICHI; IWASAKI ATSUKO; OSTERMANN NILS; SUZUKI MASAKI; TOYAO ATSUSHI; YOKOKAWA FUMIAKI; NOVARTIS AG
    摘要:3,4-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,4-substituted piperidine compound, and/or a method of treatment comprising administering a 3,4substituted piperidine compound, a method for the manufacture of a 3,4-substituted piperidine compound, and novel intermediates and partial steps for their synthesis are disclosed. The 3,4-disubstituted piperidine compounds have the formula (I), wherein the symbols have the meanings defined in the specification.

    专利号:US-8138188-B2
    优先权日:2006-02-23
    标题 :Melanocortin type 4 receptor agonist piperidinoylpyrrolidines
    发明人:ANDREWS MARK DAVID; BROWN ALAN DANIEL; LANSDELL MARK IAN; SUMMERHILL NICHOLAS WILLIAM
    权利人:ANDREWS MARK DAVID; BROWN ALAN DANIEL; LANSDELL MARK IAN; SUMMERHILL NICHOLAS WILLIAM; PFIZER
    摘要:The present invention relates to a class of melanocortin MCR4 agonists of general formula (I) n nwherein the variables and substituents are as defined herein and especially to selective MCR4 agonist compounds, to their use in medicine, particularly in the treatment of sexual dysfunction and obesity, to intermediates useful in their synthesis and to compositions containing them.

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Franciszek Herold, Et Al. Synthesis Of A New Scaffold: The 7H,8H-Pyrimido[1,6-B]Pyridazin-6,8-Dione Nucleus. Molecules. 2007 Dec 30;12(12):2643-57.

    合成参考文献


    摘要:Zhang, J., Science of Synthesis Knowledge Updates, (2010) 4, 256.
    摘要:Zhang, J., Science of Synthesis Knowledge Updates, (2010) 4, 264.
    摘要:Guram, A. S.; Milne, J. E.; Tedrow, J. S.; Walker, S. D., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 22.
    摘要:Littke, A., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 228.
    摘要:Gosmini, C.; Corpet, M., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 660.
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