CAS: 163336-15-0; (R)-5-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)-2-((Tert-Butoxycarbonyl)Amino)Pentanoic Acid
该化合物是一种受保护的氨酸衍生物,通常用于peptide合成."Boc"(乙基-丁基氧碳基)和"Fmoc"(9-氟乙基碳基)组群分别作为氨基和氨基和氨基碳基(氨基)功能的保护组群,允许在聚氨基和氨基亚酸或硝基氢(HOH)过程中有选择地作出反应.该化合物的特点是氨基酸或硝基亚酸,其特征为两个矿基组,并被归类为非蛋白基氨基酸.这些保护组的存在加强了分子的稳定性,便于其在固相聚物合成过程中使用.Boc-D-Orn(Foc)-Orn(Orn)-OHHA在表面中通常是白色到非白色的,在二甲基亚基酰胺(DMF)和二甲基硫氧化物(DSO)等有机溶剂中可溶解.其应用的应用延伸到聚化物和其他生物活性化合物的合成合成,使其在制药和合成过程中保持其基本和化学和合成过程.
- 英文名称(R)-5-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)-2-((Tert-Butoxycarbonyl)Amino)Pentanoic Acid
- 中文名称(R)-5-(((((9H-芴-9-基)甲氧基)羰基)氨基)-2-((叔丁氧基羰基)氨基)戊酸
- IUPAC名称(R)-5-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-((tert-butoxycarbonyl)amino)pentanoic acid
- 其它别名(2R)-2-{[(Tert-Butoxy)Carbonyl]Amino}-5-({[(9H-Fluoren-9-yl)Methoxy]Carbonyl}Amino)Pentanoic Acid ; Yebwaczymhwwek-Oaqylsrusa-N ; N~2~-(Tert-Butoxycarbonyl)-N~5~-{[(9H-Fluoren-9-yl)Methoxy]Carbonyl}-D-Ornithine ; N-Alpha-Boc-N-Delta-Fmoc-D-Ornithine ; (R)
- CAS编号163336-15-0
- MFCD编号:MFCD00151883
- 分子式:C25H30N2O6分子量:454.52
- 产品CID: 828404
- 产品分类有机原料→分子砌块→手性化合物→手性砌块
相似化合物
13650-49-2 150828-96-9 16682-12-5物理性质
MSDS等安全信息
上下游产品
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (R)-5-amino-2-((tert-butoxycarbonyl)amino)pentanoic acid 2-(tert-butoxycarbonyl)-L-ornithineN2-(tert-butoxycarbonyl)-L-ornithineH-Tyr-D-Orn[*]-Phe-Asp[*]-NH2 glycyl-L-arginyl-glycyl-L-aspartyl-L-seryl-L-proline合成工艺路线路线简述
📜9-芴甲基-N-琥珀酰亚胺基碳酸酯,丁氧羰基-D-鸟氨酸-Oh置于水,碳酸氢钠体系中,用 四氢呋喃 用作溶剂,化学反应 2.0H,以94%的收率获得n-叔丁氧羰基-(N'-芴甲氧羰基)-D-鸟氨酸
参考文献: Immunomodulators[fr] Immunomodulateurs
标题: Immunomodulators[fr] Immunomodulateurs
摘要:本公开提供了新型大环肽,其抑制pd-1 / Pd-L1和pd-L1 / Cd80蛋白质/蛋白质相互作用,因此可用于改善各种疾病,包括癌症和传染性疾病.
海关参考信息
- 2902600000-乙苯
2905122000-异丙醇
2905143000-叔丁醇
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2021130409-A1
优先权日:2017-09-01
标 题 :Method for the Solid-Phase Synthesis of Cyclic Pentapeptides
发明人：ZHENGGUO JIANG; LUCIANO FORNI; ROBERTSON ALAN
权利人:Alsonex Pty Ltd
摘要:A method for the synthesis of a cyclic ornithine-proline-D-cyclohexylalanine-tryptophan-arginine pentapeptide of Formula A; n n n n n n n n n n n n wherein R 1 and R 2 are, independently, —H, or —C(O)R 3 where R 3 is —CH 2 Ph, —CH 2 CH 2 Ph, —CHâ•?CHPh, —C(NHAC)CH 2 Ph;n nthe method comprising the steps of;n nforming a linear proline-D-cyclohexylalanine-tryptophan-arginine-ornithine pentapeptide of Formula B, attached to a polymeric resin;n n n n n n n n n n n n n n n n n wherein R 1 is as for Formula A, RES indicates the polymeric resin, and P 1 and P 2 are protecting groups;n ncyclising the linear pentapeptide of Formula B to form a cyclic pentapeptide of Formula C, attached to the polymeric resin;n n n n n n n n n n n n n n n cleaving the cyclic peptide of Formula C from the resin providing a cleaved cyclic pentapeptide having a free amine group of an ornithine residue;n noptionally substituting the free amine group of the ornithine residue of the cleaved cyclic peptide;n nremoving the protecting groups P 1 and P 2 , to providethe cyclic peptide of Formula A.
