CAS: 162520-00-5; 2-(((2E,6E)-3,7,11-Trimethyldodeca-2,6,10-Trien-1-yl)Thio)Benzoic Acid

上下游产品

farnesyl bromide Thiosalicylic acid ethyl farnesoate FarnesolN-(2-(diethylamino)ethyl)-2-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)benzamide N-(3-(dimethylamino)propyl)-2-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)benzamide N-(3-(diethylamino)propyl)-2-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)benzamide N-(4-(diethylamino)butyl)-2-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)benzamide

📜金合欢醇置于n-氯代丁二酰亚胺,二甲基硫,碳酸胍体系中,用 二氯甲烷,丙酮 用作溶剂,化学反应 8.0H,反应生成法尼基硫代水杨酸
参考文献:将salirasib重新定位为新的抗疟药.
标题:将salirasib重新定位为新的抗疟药.
摘要:疟疾是一种严重的热带疾病,由于恶性疟原虫感染,每年导致数千人丧生,主要是在非洲.Salirasib是一种有前途的抗癌药物,可干扰ras的翻译后修饰.该s-法呢基硫代水杨酸酯抑制异戊二烯半胱氨酸羧基甲基转移酶(icmt),这是癌症药物开发的有效靶标.人和寄生虫酶同工型之间除了具有可药用的靶点外,还具有很高的同源性.希望将其结构重新用作抗疟药,S的集合通过引入1,2,3-三唑作为多样性的进入点或通过巯基的直接烷基化来制备巯基水杨酸的β-取代的衍生物.我们进一步研究了fts类似物在无性阶段和vero细胞中对恶性疟原虫的体外毒性.使用基于纳米荧光素酶(nluc)转染的恶性疟原虫寄生虫的简单,高灵敏度的方法进行了抗血浆活性测定.结果显示,某些类似物在低微摩尔浓度下具有活性,包括salirasib.该系列中最有力的成员有s-法呢基和被植酸基取代的1,2,3-三唑部分.但是,被甲基萘基取代的化合物显示出
Doi:10.1039/c9Md00298G

专利信息

专利号:US-2021220331-A1
优先权日:2016-05-03
标题:Inhibitors of ires-mediated protein synthesis
发明人：GERA JOSEPH F; LICHTENSTEIN ALAN; JUNG MICHAEL E; LEE JIHYE; HOLMES BRENT; BENAVIDES-SERRATO ANGELICA
权利人:UNIV CALIFORNIA; THE UNITED STATE GOVERNMENT REPRESENTED BY THE DEPT OF VETERANS AFFAIRS
摘要:This disclosure relates to inhibitors of IRES-mediated protein synthesis, compositions comprising therapeutically effective amounts of these compounds, and methods of using those compounds and compositions in treating hyperproliferative disorders, e.g., cancers. This disclosure also relates to compositions comprising inhibitors of IRES-mediated protein synthesis and mTOR inhibitors, and to methods of treating cancer by conjoint administration of inhibitors of IRES-mediated protein synthesis and mTOR inhibitors.

专利号:US-2024174698-A1
优先权日:2022-09-23
标题 :Modular synthesis of 1,2-azaborines via ring-opening bn-isostere benzannulation
发明人：DONG GUANGBIN; LYU HAIRONG; CHEN ZHIJIE; WU YIFEI; CHOI SHINYOUNG
权利人:UNIV CHICAGO
摘要:The present disclosure relates generally to 1,2-azaborines and methods of making the same.

专利号:US-12221419-B2
优先权日:2022-03-30
标题:Abietanes and methods of making and using the same
发明人：FREDERICH JAMES H; SOLANS MEGAN M
权利人:FLORIDA STATE UNIV RESEARCH FOUNDATION INCORPORATED; UNIV FLORIDA STATE RES FOUND
摘要:In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein is versatile polyene cyclization strategy that exploits conjugated β-ionyl derivatives. Photomediated disruption of the extended Ï€-system within these chromophores unveils a contra-thermodynamic polyene that engages in a Heck-type cyclization to afford [4.4.1]-propellanes. The connectivity of overbred polycycles generated from this process is controlled by the position of the requisite C-Halide bond. Thus, compared to conventional biomimetic polyene cyclization, this approach allows for complete control of regiochemistry and facilitates incorporation of both electron-rich and electron-deficient (hetero)aryl groups. This strategy was successfully applied to the total synthesis of abietanes such as, for example, taxodione and salviasperanol, two isomeric abietane-type diterpenes that previously could not be prepared along the same synthetic pathway.

专利号:US-11932558-B1
优先权日:2020-03-02
标 题 :Piezocatalysis using piezoelectric polymers
发明人：EULER WILLIAM B; THACH ANGELA; SUMATHIRATHNE LASANTHI; CROMWELL BENJAMIN B; DUBNICKA MARA
权利人:UNIV OF RHODE ISLAND BOARD OF TRUSTEES
摘要:A piezoelectric polymer used as a piezocatalyst, and methods of manufacture and use therefor. A preferred piezoelectric polymer is poly(vinylidene difluoride) (PVDF) due to its piezoelectric response and good flexibility. The polymer can be doped with a metal, metal salt, metal carbonyl, metal oxide such as ZnO, Co 2 O 3 , or TiO 2 , or ion such as Cr 3+ , Co 2+ , or Zn 2+ . The dopant can be chosen so that when the polymer is PVDF the dopant increases the amount of β-phase PVDF and/or γ-phase PVDF relative to α-phase PVDF, thereby increasing the piezocatalytic response of the polymer. The compound to be decomposed can be adsorbed on the surface of the piezoelectric polymer. Applications include wastewater treatment, CO 2 capture and reduction, hydroformylation, water splitting, and ammonia synthesis.

专利号:US-12312314-B2
优先权日:2018-05-16
标题:Methods and compositions for terpenoid tricycloalkane synthesis
发明人：GRENNING ALEXANDER JAMES; SCOTT SARAH
权利人:UNIV FLORIDA
摘要:In one aspect, the disclosure relates to methods for preparation of intermediates useful for the preparation of terpenoid cores. In a further aspect, the disclosed methods pertain to the preparation of compounds comprising a terpenoid core or scaffold, such as 6/7/5 tricycloalkanes. The disclosed methods utilize abundant starting materials and simple reaction sequences that can be used to tunably and scalably assemble common terpenoid cores. In various aspects, the present disclosure pertains to compounds prepared using the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

专利号:US-11634452-B2
优先权日:2017-12-11
标 题:Compounds for treating neurodegenerative disorders
发明人：RABHI CHÉRIF; CARIEL LÉON; DA COSTA NOBLE CHRISTIAN; OUAZZANI JAMAL; ARCILE GUILLAUME; LE GOFF GÉRALDINE
权利人:ETHNODYNE; CENTRE NAT RECH SCIENT
摘要:The invention relates to compounds of formula (I), their method of synthesis as well as their use to treat neurodegenerative disorders.