CAS: 159634-87-4; N-[(R)-[(1,2-Dihydro-1-Methanesulfonylspiro[3H-Indole-3,4'-Piperidin]-1'-yl)Carbonyl]-2-(Phenylmethyloxy)Ethyl]-2-[(1,1-Dimethyl-Ethoxy)Carbonyl]Amino-2-Methyl-Propanamide

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(R)-叔丁基(3-(苄氧基)-1-(1-(甲磺酰基)螺[吲哚-3,4'-哌啶]-1'-基)-1-氧代丙烷-2-基)氨基甲酸酯 Carbamic Acid, N-[(1R)-2-[1,2-Dihydro-1-(Methylsulfonyl)Spiro[3H-Indole-3,4'-Piperidin]-1'-Yl]-2-Oxo-1-[(Phenylmethoxy)Methyl]Ethyl]-, 1,1-Dimethylethyl Ester 180465-66-1
(2R)-2-Amino-1-(1-Methylsulfonylspiro[2H-Indole-3,4'-Piperidine]-1'-yl)-3-Phenylmethoxypropan-1-One 180465-67-2
Benzyl 1-(Methylsulfonyl)Spiro[indoline-3,4’-Piperidine]-1‘-Carboxylate 184289-84-7
1-(甲基磺酰基)螺[吲哚啉-3,4’-哌啶] 1-(Methylsulfonyl)Spiro[indoline-3,4’-Piperidine] 178261-41-1
螺[吲哚啉-3,4’-哌啶]-1’-羧酸苄酯 Benzyl Spiro[indoline-3,4'-Piperidine]-1'-Carboxylate 167484-18-6

📜螺[吲哚啉-3,4'-哌啶]-1'-羧酸苄酯置于palladium 10% On Activated Carbon,氢气,1-羟基苯并三唑,N,N-二异丙基乙胺,N,N'-二环己基碳二亚胺体系中,用 四氢呋喃,乙醇,醋酸异丙酯,水 用作溶剂,化学反应生成N-[(R)-[(1,2-二氢-1-甲基磺酰螺[3H-Indoole-3,4'-哌啶]-1'-基)羰基]-2-(苯基甲氧基)乙基]-2-[(1,1-二甲基乙氧基)羰基]氨基-2-甲基-丙酰胺
参考文献:基于螺吲哚啉的生长激素促分泌素mk-677的简便合成
标题:基于螺吲哚啉的生长激素促分泌素mk-677的简便合成
摘要:摘要描述了一种合成基于口服活性螺环二氢吲哚的生长激素促分泌素mk-677的简便方法.关键步骤采用了菲舍尔吲哚/还原策略.还优化了关键中间体n-保护的哌啶羧醛5和n-Boc-O-苄基-D-丝氨酸(2)的制备.
Doi:10.1016/j.Cclet.2012.03.032