CAS: 142628-53-3; 2,4,6-Trihydroxy-5-((R)-3-Methyl-1-((1Ar,4Ar,7S,7Ar,7Br)-1,1,7-Trimethyl-4-Methylenedecahydro-1H-Cyclopropa[e]Azulen-7-yl)Butyl)Isophthalaldehyde

上下游产品

2,4>undec-11-yl)-3'-methylbutyl>-2,4,6-trimethoxyisophthalaldehyde(+)-5-(1'R)-1'-((1R,2R,4R,8R,11S)-3,3,11-trimethyl-7-methylenetricyclo6.3.0.02,4undec-11-yl)-3'-methylbutyl-2,4,6-trimethoxyisophthalaldehyde 2,4>undec-11-yl)-3'-methylbutyl>-2,4,6-trimethoxybenzene-1,3-dimethanol(+)-5-(1'R)-1'-((1R,2R,4R,8R,11S)-3,3,11-trimethyl-7-methylenetricyclo6.3.0.02,4undec-11-yl)-3'-methylbutyl-2,4,6-trimethoxybenzene-1,3-dimethanol (1aR,4S,7R,7aR,7bR)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-1,1,7-trimethyl-1a,3,4,7,7a,7b-hexahydro-1H,2H-cyclopropa[e]azulen-6-one -3,3,11-trimethyltricyclo2,4>undeca-8,10-diene(-)-(1S,2R,4R,7S)-10-(tert-butyldimethylsiloxy)-7-(tert-butyldimethylsiloxy)methyl-3,3,11-trimethyltricyclo6.3.0.02,4undeca-8,10-diene 35H52O8C35H52O8 (1aR,4R,4aR,7S,7aS,7bR)-7-[(R)-1-(3,5-Bis-hydroxymethyl-2,4,6-trimethoxy-phenyl)-3-methyl-butyl]-1,1,4,7-tetramethyl-decahydro-cyclopropa[e]azulen-4-ol 2,4>undec-11-yl)-3'-methylbutyl>-2,4,6-trimethoxybenzene-1,3-dimethanol(+)-5-(1'R)-1'-((1R,2R,4R,8R,11S)-3,3,11-trimethyl-7-methylenetricyclo6.3.0.02,4undec-11-yl)-3'-methylbutyl-2,4,6-trimethoxybenzene-1,3-dimethanol

📜(-)-Dimethyl 5-<(1'R)-1'-((1R,2R,4R,7S,8R,11S)-7-(Hydroxymethyl)-3,3,11-Trimethyltricyclo<6.3.0.02,4>Undec-9-En-11-yl)-3'-Methylbutyl>-2,4,6-Trimethoxyisophthalate置于palladium On Activated Charcoal 六甲基磷酰三胺,2-硝基苯基丝氰酸酯,四丙基高钌酸铵,三丁基膦,氢气,双氧水,二异丁基氢化铝,Lithium P-Toluenethiolate,N-甲基吗啉氧化物体系中,用 甲醇,甲苯,乙腈 用作溶剂,-78.0~50.0 °C,506.62 Kpa 条件下,反应生成大果桉醛c
参考文献:First Stereoselective Total Synthesis Of Macrocarpal C: Structure Elucidation Of Macrocarpal G
标题:First Stereoselective Total Synthesis Of Macrocarpal C: Structure Elucidation Of Macrocarpal G
摘要:首次实现了大果壳素c的立体选择性全合成,该合成通过硅醚二烯醇与新型六取代苯铬三羰基复合物(作为光学活性苄基阳离子等价物)的偶联反应完成,从而阐明了大果壳素c和大果壳素g的身份.
Doi:10.1039/a705231F

专利信息

专利号:US-2002165207-A1
优先权日:2001-05-02
标题 :Compositions and methods for the treatment of diabetic neuropathy
发明人：ROSENBLOOM RICHARD
摘要:Compositions and a method for the treatment of diabetic neuropathy is disclosed. The compositions comprise a mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant, optionally formulated in a pharmaceutically acceptable carrier. This combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In addition, the compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. n In a second aspect, a method for the administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is administered on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms of diabetic neuropathy, as well as at least some recovery of the damaged nerve tissues.