CAS: 135427-08-6; 4-Fluoro-3-Methylbenzaldehyde

相似化合物

185147-08-4 403-15-6 180636-50-4

上下游产品

5-bromo-2-fluorotoluene N,N-dimethyl-formamide dihydroxy-methyl-borane 3-bromo-4-fluorobenzaldehyde 3-(4-fluoro-3-methylphenyl)-1-phenyl-2-propen-1-one 4-fluoro-3-methylbenzonitrile tert-butyl (E)-3-(3-fluoro-4-methylphenyl)acrylate 3-methyl-4-fluor°Cinnamic acid

Trifluoromethanesulfonic Acid 4-Formyl-2-Methylphenyl Ester置于[cod(Pd-Alphos)2],Cesium Fluoride体系中,用 甲苯 用作溶剂,化学反应 96.0H,以84%的收率获得4-氟-3-甲基苯甲醛
参考文献:A Fluorinated Ligand Enables Room-Temperature And Regioselective Pd-Catalyzed Fluorination Of Aryl Triflates And Bromides
标题:A Fluorinated Ligand Enables Room-Temperature And Regioselective Pd-Catalyzed Fluorination Of Aryl Triflates And Bromides
摘要:A New Biaryl Monophosphine Ligand (Alphos,L1) Allows For The Room-Temperature Pd-Catalyzed Fluorination Of A Variety Of Activated (Hetero)Aryl Trifiates. Furthermore,Aryl Triflates And Bromides That Are Prone To Give Mixtures Of Regioisomeric Aryl Fluorides With Pd-Catalysis Can Now Be Converted To The Desired Aryl Fluorides With High Regioselectivity. Analysis Of The Solid-State Structures Of Several Pd(II) Complexes,As Well As Density Functional Theory (Dft) Calculations,Shed Light On The Origin Of The Enhanced Reactivity Observed With L1.
Doi:10.1021/jacs.5B09308

专利信息

专利号:US-5138099-A
优先权日:1991-07-31
标题:Synthesis of fluorobenzaldehydes
发明人：LANG JOHN F
权利人:MALLINCKRODT SPEC CHEM
摘要:4-fluorobenzaldehydes are formed from compounds of the formula (I) ##STR1## wherein R 1 , R 2 , R 3 and R 4 are the same or different, and represent H, halogen, or an alkyl group of from 1 to about 10 carbon atoms, wherein, when at least one of R 1 , R 2 , R 3 or R 4 is halogen, at least one of remaining R 1 , R 2 , R 3 or R 4 is alkyl. the compound of formula of (I) is reacted with a formylating agent in the presence of FeCl 3 in a reaction mixture, from which is separated a compound of the formula (II) ##STR2## wherein R 1 , R 2 , R 3 and R 4 are as defined above.