CAS: 132996-61-3; ((S)-2-(2-((S)-5-Amino-2-((S)-2-((S)-6-Amino-2-((S)-2-((S)-2-Aminopropanamido)-4-Methylpentanamido)Hexanamido)-5-((Diaminomethylene)Amino)Pentanamido)-5-Oxopentanamido)Acetamido)-5-((Diaminomethylene)Amino)Pentanoyl)-L-Threonyl-L-Leucyl-L-Tyrosylglycyl-L-Phenylalanylglycylglycine

专利信息

专利号:US-9988492-B2
优先权日:2013-09-30
标题:Methods for post-fabrication functionalization of poly(ester ureas)
发明人：BECKER MATTHEW; LIN FEI
权利人:BECKER MATTHEW; LIN FEI; UNIV AKRON
摘要:Amino acid-based poly(ester urea)s (PEU) are emerging as a class of polymers that have shown promise in regenerative medicine applications. Embodiments of the invention relate to the synthesis of PEUs carrying pendent “clickableâ€? groups on modified tyrosine amino acids. The pendent species include alkyne, azide, alkene, tyrosine-phenol, and ketone groups. PEUs with M w exceeding 100k Da were obtained via interfacial polycondensation methods and the concentration of pendent groups was varied by copolymerization. The incorporation of derivatizable functionalities is demonstrated using 1 H NMR and UV-Vis spectroscopy methods. Electrospinning was used to fabricate PEU nanofibers with a diameters ranging from 350 nm to 500 nm. The nanofiber matricies possess mechanical strengths suitable for tissue engineering (Young's modulus: 300±45 MPa; tensile stress: 8.5±1.2 MPa). A series of bioactive peptides and fluorescent molecules were conjugated to the surface of the nanofibers following electrospinning using bio-orthogonal reactions in aquous media.

专利号:US-10765748-B2
优先权日:2014-07-11
标题 :Composition and methods for tethering bioactive peptides to metal oxide surfaces
发明人：BECKER MATTHEW; TANG WEN
权利人:BECKER MATTHEW; TANG WEN; UNIV AKRON
摘要:In various aspects, embodiments of the present invention are directed to a series of multivalent dendrons containing a bioactive peptide domain and surface-binding catechol domains. In some embodiments, these multivalent dendrons were obtained through solid phase synthesis and have a strong binding affinity to metal oxide surfaces such as, TiO 2 , ZrO 2 , CeO 2 , and Fe 3 O 4 , SiO2, as well as other inorganic surfaces such as hydroxyapatite, silver, fluorapatite, calcium carbonate and gold. These catechol-bearing dendrons provide a fast and efficient method to functionalize a wide range of inorganic materials with bioactive peptides and have the potential to be used in coating orthopaedic implants and fixation devices.

专利号:US-10280261-B2
优先权日:2014-05-07
标题:Radioopaque, iodine functionalized phenylalanine-based poly(ester urea)s
发明人：BECKER MATTHEW L; LI SHAN
权利人:BECKER MATTHEW L; LI SHAN; UNIV AKRON
摘要:In one or more embodiments, the present invention provides iodine-functionalized phenylalanine-based poly(ester urea)s (PEUs) (and related methods for their synthesis and use) that are metal free, degradable, radiopaque and suitable for use in surgical implants and other medical devices used within a patient. In one or more embodiment of the present invention 4-Iodo-L-phenylalanine and L-phenylalanine are separately reacted with 1,6-hexanediol to produce two monomers, bis-4-I-L-phenylalanine-1,6-hexanediol-diester (1-IPHE-6 monomer) and bis-L-phenylalanine-1,6-hexanediol-diester (1-PHE-6 monomer). It has been found that by varying the feed ratio of the 1-IPHE-6 and 1-PHE-6 monomers, the copolymer composition may be modulated to predictably create phenylalanine-based PEUs having a wide variation in thermal, mechanical and radiopacity properties. As most medical device procedures require placement verification via fluoroscopic imaging, materials that possess inherent X-ray contrast are valuable for a number of applications.

专利号:US-11103613-B2
优先权日:2016-04-28
标题 :Phosphorylated poly (ester-urea) based degradable bone adhesives
发明人：BECKER MATTHEW; BHAGAT VRUSHALI DINKAR
权利人:UNIV AKRON
摘要:In various aspects, the present invention provides a degradable and resorbable novel phosphate functionalized amino acid-based poly(ester urea) adhesive and related methods for its synthesis and use. These adhesives are formed from phosphate functionalized PEU polymers and copolymers crosslinked using one or more divalent metal crosslinking agents. The phosphate functionalized amino acid-based poly(ester urea) adhesives of various embodiments of the present invention have been found particularly effective in bonding bone to either bone or metal and have demonstrated adhesive strengths on bone samples that were significant and comparable to commercially available poly(methyl methacrylate) bone cement.