CAS: 112281-77-3; Tetraconazole

该化合物是一种属于三硝基甲醇类的合成真菌杀菌剂,主要用于农业,以控制作物中各种真菌疾病,其作用是抑制作为真菌细胞膜基本成分的Ergosterol的生物合成,从而干扰真菌生长和繁殖.Tetraconazole的特征是,它针对诸如生锈,模具和树苗等病原体的广泛频谱活动,使其有效用于各种作物,包括谷物和水果.该化合物通常用作花生喷雾,因其系统特性而闻名,允许在植物内吸收和转移.就物理特性而言,四氯甲醇一般在室内温度下是固体,水溶性较低,但有机溶剂溶解性较高.在各种环境条件下,它的稳定有助于其在农业应用方面的效力.与许多农用化学品一样,适当的处理和应用对于尽量减少潜在的环境影响并确保非目标生物的安全至关重要.

结构式图片

欧盟法规

统一分类与标签REACH注册ECHA物质ECHA物质工作场所安全标识要求化妆品禁用物质清单C&L通报欧盟农药活性物质REACH预注册废弃物危险特性清单

上下游产品

polytetrafluoroethylene(-)-S-1-[2-(2,4-dichlorophenyl)-3-(1,1,2,2-tetrafluoroethoxy)propyl]-1H-1,2,4-triazole (+)-R-1-[2-(2,4-dichlorophenyl)-3-(1,1,2,2-tetrafluoroethoxy)propyl]-1H-1,2,4-triazole (+)-tetraconazole (-)-tetraconazole

合成工艺路线路线简述

    2-(2,4-Dichlorophenyl)-3-(1H-1,2,4-Triazol-1-yl)Propan-1-Ol 反应生成四氟醚唑
    参考文献:Fungicidal Azolyl-Derivatives
    标题:Fungicidal Azolyl-Derivatives
    摘要:本发明涉及具有以下式的化合物:##str1## 其中:M = 0,1; N = 0,1; Z = Ch,N; R.Sub.1选自氯,溴,氟,Cf.Sub.3,苯基,C.Sub.1-C.Sub.2-烷氧基,C.Sub.1-C.Sub.2-卤代烷氧基,烷硫基和卤代烷硫基,其中卤素为cl,Br,F; R.Sub.2为h,氟,氯或溴; R.Sub.3表示h,Ch.Sub.3,Cn,或者当m = 1或n = 1且r.Sub.4,R.Sub.5为h时也可以是f; R.Sub.4,R.Sub.5独立地为h或f; 当m = 0时,R.Sub.3和r.Sub.4还可以表示在式(I)中它们所连接的两个碳原子之间的第二个键; R.Sub.F选自包含高达4个碳原子,至少含有2个f原子和可选的其他卤素(cl和br)的聚氟烷基,聚氟烯基和聚氟炔基的群.包含这些新化合物的抗真菌组合物.

    海关参考信息

    专利信息


    专利号:WO-2025056767-A1
    优先权日:2023-09-15
    标题 :Process for the preparation of enantiomerically enriched aliphatic amines
    发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS
    权利人:SYNGENTA CROP PROTECTION AG
    摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.

    专利号:US-2016073631-A1
    优先权日:2013-03-04
    标 题 :Process for the preparation of dihydropyrrole derivatives
    发明人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS
    权利人:SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD
    摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) n n n n n n n n n n n n wherein n P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; n R 1 is chlorodifluoromethyl or trifluoromethyl; n R 2 is optionally substituted aryl or optionally substituted heteroaryl; n n is 0 or 1; n including the process comprising n (a-i) reacting a compound of formula II n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; n with nitromethane in the presence a chiral catalyst to give a compound of formula III n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; and n (a-ii) reductively cyclising the compound of formula III to give the compound of formula I. n n n n n The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).

    专利号:US-9233920-B2
    优先权日:2010-06-11
    标题 :Process for the preparation of dihydropyrrole derivatives
    发明人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS
    权利人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS; SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD
    摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) wherein P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; R 1 is chlorodifluoromethyl or trifluoromethyl; R 2 is optionally substituted aryl or optionally substituted heteroaryl; n is 0 or 1; including the process comprising (a-i) reacting a compound of formula II wherein P, R 1 and R 2 are as defined for the compound of formula I; with nitromethane in the presence a chiral catalyst to give a compound of formula III Wherein P, R 1 and R 2 are as defined for the compound of formula I; and (a-ii) reductively cyclizing the compound of formula III to give the compound of formula I. The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).

    专利号:WO-2023089578-A1
    优先权日:2021-11-22
    标题:A synthesis process of iron-bearing compositions and possible additional essential elements
    发明人:MORMILE SILVIA; GUSMEROLI MARILENA; ZANARDI GIAMPAOLO; BIANCHI DANIELE; COTROMINO MICHELE; SARGIOTTO CHIARA; LIGUORI RICCARDO
    权利人:GOWAN CROP PROT LIMITED
    摘要:A synthesis process of iron-bearing compositions and possible additional essential elements is described for treating nutritional deficiencies in plants, in particular for the prevention and treatment of physiological alterations or nutritional unbalances in plants due to the deficiency of iron and other essential elements, and the iron-bearing compositions and possibly further essential elements obtained with said process.

    专利号:US-10906880-B2
    优先权日:2016-01-26
    标题:Kind of isothiazole oxime ether-containing strobilurin derivatives and its preparation methods and application
    发明人:FAN ZHIJIN; CHEN LAI; GUO XIAOFENG; ZHU YUJIE; QIAN XIAOLIN; MA LIUYONG; ZHANG NAILOU; WANG HAIXIA; ZHANG ZHIMING; XU JINGHUA; SONG YINQI
    权利人:UNIV NANKAI
    摘要:The present invention is that provided a synthesis method of a series of isothiazole oxime ether containing strobilurin derivatives IV. The present invention relates to 3,4-dichloroisothiazolyl oxime ether strobilurin derivatives, and their chemical structural formula is as shown by IV. n n n n n n n n n n The invention discloses the structural formula of the above compound, the synthesis method and the use as an insecticide, a fungicide, an anti-plant virus agent, and an agriculturally acceptable auxiliary or synergist and a commercial insecticide. The use of a fungicide, an anti-plant virus agent and an acaricide in combination for controlling agricultural, forestry, horticultural plant pests, diseases, virus diseases and preparation methods.

    专利号:US-2007232495-A1
    优先权日:2006-03-24
    标题:Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof
    发明人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
    权利人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
    摘要:The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.
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    主要参考文献


    1: Li J, Dong F, Xu J, Liu X, Li Y, Shan W, Zheng Y. Enantioselective determination of triazole fungice tetraconazole by chiral high-performance liquid chromatography and its application to pharmacokinetic study in cucumber, muskmelon, and soils. Chirality. 2012 Apr;24(4):294-302. doi: 10.1002/chir.21997. Epub 2012 Jan 25.

    合成参考文献


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    摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
    参考文献:10.1016/j.chroma.2004.02.078
    摘要:Sannino A, Bolzoni L, Bandini M. Application of liquid chromatography with electrospray tandem mass spectrometry to the determination of a new generation of pesticides in processed fruits and vegetables. J Chromatogr A. 2004 May 21;1036(2):161–9. doi: 10.1016/j.chroma.2004.02.078.
    参考文献:10.1186/s12940-015-0070-3
    摘要:Booth BJ, Ward MH, Turyk ME, Stayner LT. Agricultural crop density and risk of childhood cancer in the midwestern United States: an ecologic study. Environmental Health. 2015 Oct 15;14(1):82. doi: 10.1186/s12940-015-0070-3.
    参考文献:10.1021/tx900325g
    摘要:Martin MT, Dix DJ, Judson RS, Kavlock RJ, Reif DM, Richard AM, Rotroff DM, Romanov S, Medvedev A, Poltoratskaya N, Gambarian M, Moeser M, Makarov SS, Houck KA. Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program. Chem Res Toxicol. 2010 Mar 15;23(3):578–90. doi: 10.1021/tx900325g.
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