CAS: 918642-61-2; 1-((2-Fluorophenyl)Carbamoyl)Cyclopropanecarboxylic Acid

该化合物是一种化学化合物,其特点是环丙烷环结构,这是一个三环碳环,以其菌株和反应性闻名,由三环碳环组成.一个箱式酸功能组(COOH)的存在表明,它可以作为一种酸发挥作用,能够捐赠一个质子.该化合物还具有一种氨基化合物组的碳基联系,该碳基组来自二氟苯,它既能向分子引入极地特性,又能引入芳香特性.苯环上的氟原子可影响化合物的电子特性,有可能增强某些溶剂的再活动性和溶性.

英文名称1-((2-Fluorophenyl)Carbamoyl)Cyclopropanecarboxylic Acid
中文名称1-((2-氟苯基)氨基甲酰基)环丙烷甲酸(卡博替尼杂质)
IUPAC名称1-((2-fluorophenyl)carbamoyl)cyclopropane-1-carboxylic acid
其它别名Cyclopropanecarboxylic Acid, 1-[[(2-Fluorophenyl)Amino]Carbonyl]-; 1-[(2-Fluorophenyl)Carbamoyl]Cyclopropanecarboxylic Acid; 1-((2-Fluorophenyl)Carbamoyl)Cyclopropanecarboxylic Acid (Cabozantinib Impurity）; Cabozantinib Impurities6; 1-[[(2-Fluorophenyl)Amino]Carbonyl]Cyclopropanecarboxylic Acid; Cabozantinib Impurity 81; Impurity 8
CAS编号918642-61-2
MFCD编号:MFCD16676129
FDA UNII编号:R24D387W2Q
分子式:C11H10FNO3分子量:223.2
产品CID: 1956864
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: WSDNYZVNBWULFS-UHFFFAOYSA-N
InChI=1S/C11H10FNO3/c12-7-3-1-2-4-8(7)13-9(14)11(5-6-11)10(15)16/h1-4H,5-6H2,(H,13,14)(H,15,16)
计算化学: 氢键受体数4.0氢键供体数2.0可旋转键数3.0

MSDS等安全信息

警示词Warning
危险描述H315-H319-
防范说明P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364-
安全声明H303+H313+H333

上下游产品

2-Fluoroaniline 1-(chlor°Carbonyl)cyclopropane-1-carboxylic acid cyclopropane-1,1-dicarboxylic acid[4-(3-fluoro-4-{[1-(2-fluorophenylcarbamoyl)cyclopropanecarbonyl]amino}phenoxy)pyridin-2-yl]-N-(phenoxycarbonyl)carbamic acid phenyl ester

合成工艺路线路线简述

598-10-7 = 918642-61-2
反应条件:1.1 Reagents: Triethylamine Solvents: Tetrahydrofuran; Rt; 30 Min,0 °C1.2 Reagents: Thionyl Chloride; 30 Min,0 °C1.3 Solvents: Tetrahydrofuran; 4 H,0 °C
标题:Preparation Of Thienopyridine Compounds As Inhibitors Of Vegf Receptor And Hgf Receptor Signaling
参考文献:United States]

598-10-7 = 918642-61-2
反应条件:1.1 Reagents: Thionyl Chloride Solvents: Isopropyl Acetate; 0 °C; 6 H,Rt1.2 Reagents: Triethylamine Solvents: Isopropyl Acetate; 1 H,Rt; 2 H,Rt
标题:Discovery Of A Highly Potent,Selective And Novel Cdk9 Inhibitor As An Anticancer Drug Candidate
作者:Li,Yongtao; Guo,Qingxiang; Zhang,Chao; Huang,Zhi; Wang,Tianqi; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2017 卷标:27(15) 页码:3231-3237]

598-10-7 = 918642-61-2
反应条件:1.1 Reagents: Triethylamine Solvents: Tetrahydrofuran; Cooled; 30 Min,Cooled1.2 Reagents: Thionyl Chloride; Cooled; 30 Min,Cooled1.3 Solvents: Tetrahydrofuran; Cooled; Overnight,Rt1.4 Reagents: Sodium Hydroxide Solvents: Water
标题:Novel Pyridine Derivatives And Pyrimidine Derivatives As Hgfr Inhibitors And Their Preparation And Use In The Treatment Of Diseases
参考文献:United States]

598-10-7 = 918642-61-2
反应条件:1.1 Reagents: Thionyl Chloride Solvents: Isopropyl Acetate; 0 °C; 6 H,Rt1.2 Reagents: Triethylamine Solvents: Isopropyl Acetate; Rt; 1 H,Rt; 2 H,Rt
标题:Preparing Method And Application Of 1,1-Cyclopropyl Diamide Derivative
参考文献:China]

= 918642-61-2 [标题:Reaction Conditions
标题:Preparation Of Pyridines And Pyrimidines Having Cyclopropane-1,1-Dicarboxamide Moiety As Hgfr Inhibitors
参考文献:World Intellectual Property Organization

📜2-氟苯胺置于三乙胺,氯化亚砜,盐酸,Sodium Hydroxide,水体系中,用四氢呋喃作为反应溶剂,化学反应 1.0H,以54%的收率获得产物1-((2-氟苯基)氨基甲酰基)环丙烷甲酸(卡博替尼杂质)
参考文献:Novel Pyridine Derivative And Pyrimidine Derivative (3)
标题:Novel Pyridine Derivative And Pyrimidine Derivative (3)