CAS: 82419-32-7; 1-(2,3-Difluoro-6-Nitrophenoxy)Propan-2-One

该化合物是一种氟化硝化化合物,可能用于制药和农用化学合成.其结构具有与propan-2-1组相连的二氟-四氟氧基混合物特征,为进一步功能化提供了适应性.电离式硝化氢和氟替代成分增强了其作为核生殖性替代反应中间体的效用.该化合物独特的替代模式可能有助于改善合成途径的稳定性和选择性.其定义明确的分子结构使其成为开发专门精细化学品的宝贵建筑块,特别是在需要受控的电益性或激进再活动的情况下.由于它的硝酸性性质,建议正确处理.

英文名称1-(2,3-Difluoro-6-Nitrophenoxy)Propan-2-One
中文名称醚酮
IUPAC名称1-(2,3-difluoro-6-nitrophenoxy)propan-2-one
其它别名2-Acetonyloxy-3,4-Difluoro Nitrobenzene; [(2,3-Difluoro-6-Nitro) Phenoxy] Acetone; 1-(2,3-Difluoro-6-Nitrophenoxy)-2-Propanone; 2-Acetonyloxo-3,4-Difluoronitrobenzene; 1-(2,3-Difluoro-6-Nitrophenoxy; 5,6-Difluoro-3-Nitro-4-(2-Oxopropyl)-1-Cyclohexa-2,4-Dienone; 1-Acetone-Oxo-3,4-Difluoro-Nitrobenzene
CAS编号82419-32-7
MFCD编号:MFCD00792468
分子式:C9H7F2NO4分子量:231.15
产品CID: 1814918
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: ZJVPAAJHCJMGGL-UHFFFAOYSA-N
InChI=1S/C9H7F2NO4/c1-5(13)4-16-9-7(12(14)15)3-2-6(10)8(9)11/h2-3H,4H2,1H3
计算化学: 氢键受体数4.0氢键供体数*可旋转键数4.0

相似化合物

1233954-79-4 66684-60-4 1233955-17-3

MSDS等安全信息

GHS符号GHS06
警示词Danger
危险描述H301
防范说明P264-P270-P330-P405-P501
危险等级6.1
UN编号2811.0
危险品标志Xi,T
包装等级Ⅲ
安全声明37/39-26-45
危险类别码36/37/38-25

上下游产品

合成工艺路线路线简述

10004-17-8 + 771-69-7 = 82419-32-7
反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Toluene; 3 H,-5 - 0 °C2.1 Reagents: Hydrochloric Acid Solvents: Methanol,Water; 3 H,70 °C
标题:Modified Route For Synthesis Of Ofloxacin
作者:Wang,Xundao; Et Al
参考文献:Zhongguo Kangshengsu Zazhi 日期:2003 卷标:28(6) 页码:341-343]

10004-17-8 + 771-69-7 = 82419-32-7
反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Toluene2.1 Reagents: Hydrochloric Acid Solvents: Methanol
标题:Synthesis Of 2-Acetonyloxo-3,4-Difluoronitrobenzene
作者:Wang,Bin; Et Al
参考文献:Huaxue Shiji 日期:2001 卷标:23(4)]

82419-26-9 = 82419-32-7
反应条件:1.1 Reagents: Sodium Bicarbonate Catalysts: Potassium Bromide,Methyltributylammonium Chloride Solvents: Toluene,Water; 24 H,65 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 6.5 - 7,55 - 60 °C
标题:Chemoenzymatic Asymmetric Synthesis Of 1,4-Benzoxazine Derivatives: Application In The Synthesis Of A Levofloxacin Precursor
作者:Lopez-Iglesias,Maria; Et Al
参考文献:Journal Of Organic Chemistry 日期:2015 卷标:80(8) 页码:3815-3824]

393-79-3 = 82419-32-7 [标题:Reaction Conditions
标题:Anti-Acid-Fast Bacteria Agents
参考文献:Japan]

117321-75-2 = 82419-32-7
反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Methanol,Water; 3 H,70 °C
标题:Modified Route For Synthesis Of Ofloxacin
作者:Wang,Xundao; Et Al
参考文献:Zhongguo Kangshengsu Zazhi 日期:2003 卷标:28(6) 页码:341-343]

117321-75-2 = 82419-32-7
反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Methanol
标题:Synthesis Of 2-Acetonyloxo-3,4-Difluoronitrobenzene
作者:Wang,Bin; Et Al
参考文献:Huaxue Shiji 日期:2001 卷标:23(4)]

82419-26-9 = 82419-32-7
反应条件:1.1 Reagents: Sodium Bicarbonate,Potassium Bromide,Methyltributylammonium Chloride Solvents: Toluene; 6 H,65 °C1.2 18 H,65 °C1.3 Reagents: Water; Ph 6.5 - 7
标题:Enantioselective Biocatalytic Reduction Of 2H-1,4-Benzoxazines Using Imine Reductases
作者:Zumbraegel,Nadine; Et Al
参考文献:Journal Of Organic Chemistry 日期:2019 卷标:84(3) 页码:1440-1447]

82419-26-9 = 82419-32-7
反应条件:1.1 Reagents: Potassium Carbonate,Potassium Iodide Solvents: Acetone
标题:Synthesis Of Fluoroquinolone Antimicrobial Agent Ofloxacin
作者:Wang,Erhua; Et Al
参考文献:Zhongguo Yiyao Gongye Zazhi 日期:1991 卷标:22(9) 页码:385-7]

169468-83-1 = 82419-32-7 [标题:Reaction Conditions
标题:Pyrido[1,2,3-De][1,4]Benzoxazines
参考文献:Japan]

771-69-7 = 82419-32-7
反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Water2.1 Reagents: Potassium Carbonate,Potassium Iodide Solvents: Acetone
标题:Synthesis Of Fluoroquinolone Antimicrobial Agent Ofloxacin
作者:Wang,Erhua; Et Al
参考文献:Zhongguo Yiyao Gongye Zazhi 日期:1991 卷标:22(9) 页码:385-7

📜2,3,4-三氟硝基苯置于氢氧化钾,Potassium Carbonate,Potassium Iodide体系中,用水,二甲基亚砜,丙酮作为反应溶剂,化学反应 6.0H,反应生成 2-丙酮氧基-3,4-二氟硝基苯
参考文献:Synthesis And Antibacterial Activities Of Substituted 7-Oxo-2,3-Dihydro-7H-Pyrido(1,2,3-De)(1,4)Benzoxazine-6-Carboxylic Acids.
标题:Synthesis And Antibacterial Activities Of Substituted 7-Oxo-2,3-Dihydro-7H-Pyrido(1,2,3-De)(1,4)Benzoxazine-6-Carboxylic Acids.
摘要:作为寻找新的合成抗菌剂以对抗全身感染的一部分,合成了多种7-氧代-2,3-二氢-7H-吡啶并[1,2,3-De][1,4]苯并噁嗪-6-羧酸类似物.在合成的新化合物中,9-氟-3-甲基-10-(4-甲基-1-哌嗪基)-7-氧代-2,3-二氢-7H-吡啶并[1,2,3-De][1,4]苯并噁嗪-6-羧酸(dl-8280)显示出对革兰氏阳性和阴性病原体,包括铜绿假单胞菌的强效抗菌活性,并且其代谢情况在单独的实验中显示为有利.
DOI:10.1248/cpb.32.4907