CAS: 764-33-0; 2-Hexynoic Acid

相似化合物

764-60-3 5663-96-7 5963-77-9

上下游产品

2-己炔酸乙酯 Ethyl 2-Hexynoate 16205-90-6
2-己炔-1-醇 Hex-2-Yn-1-Ol 764-60-3

📜2-己炔酸乙酯置于sodium Hydroxide,苄基三乙基氯化铵体系中,用 乙醚,水 作为反应溶剂,化学反应 120.0H,反应生成 2-己炔酸
参考文献:Flash Vacuum Pyrolysis Of Stabilised Phosphorus Ylides. Part 4. Stepwise Construction Of Terminal 1,3-Diynes,Conjugated Diacetylenic Esters And A Triacetylenic Ester
标题:Flash Vacuum Pyrolysis Of Stabilised Phosphorus Ylides. Part 4. Stepwise Construction Of Terminal 1,3-Diynes,Conjugated Diacetylenic Esters And A Triacetylenic Ester
摘要:Thirteen Examples Of Stabilised Alkynoyl Ylides 6 Have Been Prepared And Are Found,Upon Flash Vacuum Pyrolysis (Fvp) At 500 Degrees C,To Undergo Extrusion Of Ph(3)Po To Give The Diacetylenic Esters 7 In Moderate Yield. At 750 Degrees C The Same Ylides Afforded Terminal 1.3-Diynes 8 Although Often In Poor Yield. For R = 2-Mesc(6)H(4) Both 7 And 8 Undergo Secondary Loss Of Me(.) And Cyclisation To Give 2-Alkynylbenzothiophene Derivatives 9 And 10 In Low Yield. The First Example Of An Alkadiynoyl Ylide 11 Has Been Prepared And Is Converted By Fvp At 500 Degrees C Into The Triacetylenic Ester 12.
DOI:10.1039/p19940002461

专利信息

专利号:US-8951728-B2
优先权日:2004-11-22
标 题:Template directed split and mix synthesis of small molecule libraries
发明人：RASMUSSEN PETER BIRK
权利人:CHEMGENE HOLDING APS
摘要:The invention combines the advantages of split and mix synthesis with the advantages of template directed synthesis. The method comprises the steps of: a) adding a linker molecule L to one or more reaction wells; b) adding a molecule fragment to each of said reaction wells; c) adding an oligonucleotide identifier to each of said reaction wells; d) subjecting said wells to conditions sufficient to allow said molecule fragments and said oligonucleotide identifiers to become attached to said linker molecule, or conditions sufficient for said molecule fragments to bind to other molecule fragments and sufficient for said oligonucleotide identifiers to bind to other oligonucleotide identifiers; e) combining the contents of said one or more reaction wells; and f) contacting the resulting bifunctional molecule(s) of step e) with one or more (oligonucleotide) templates each capable of hybridizing to at least one of the oligonucleotide identifiers added in step c).

专利号:US-2014296354-A1
优先权日:2013-04-01
标题 :Synthesis of peptoid-based small molecular gelators from multiple component reactions
发明人：WANG GUIJUN; MANGUNURU HARI P R
权利人:WANG GUIJUN; MANGUNURU HARI P R; OLD DOMINION UNIV RES FOUND
摘要:Described herein are the one-pot synthesis and characterization of a library of low molecular weight peptoid compounds that are able to form gels at room temperature. The compounds are synthesized from biologically-based starting materials, are biocompatible, and are resistant to degradation by proteases and peptidases. The compounds and gels synthesized therefrom can be used in such applications as tissue engineering, drug delivery, separation of biomolecules, and stimulus-responsive advanced materials

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-6313364-B1
优先权日:1999-10-28
标 题:Synthesis of cyclopropaneacetylene using a catalytic decarboxylation reaction
发明人：BRANDS KAREL M J
权利人:MERCK & CO INC
摘要:The present invention relates to a process for the preparation of cyclopropaneacetylene by the two step process: (1) an alkylation of propiolic acid with a 1,3-disubstituted propane followed by a cycloalkylation to give a 3-cyclopropaneacetylene carboxylic acid; and (2) decarboxylation of 3-cyclopropaneacetylene carboxylic acid in the presence of copper catalyst.

专利号:US-9889182-B2
优先权日:2009-09-15
标 题 :Assisted enzyme replacement therapy
发明人：ESKO JEFFREY D; TOR YITZHAK
权利人:ESKO JEFFREY D; TOR YITZHAK; UNIV CALIFORNIA
摘要:Reagents and methods useful for the synthesis of conjugates comprising guanidinylated cyclic acetals are provided. Also provided are methods for increasing the cellular uptake of various therapeutic compounds and treatment modalities using these conjugates.

专利号:US-10787576-B2
优先权日:2015-04-30
标 题 :Method for the preparation of a coating comprising oligomeric alkynes
发明人：FRAUENRATH HOLGER; SCHRETTL STEPHEN; SCHULTE BJOERN; LETERRIER YVES
权利人:ECOLE POLYTECHNIQUE FED DE LAUSANNE EPFL EPFL TTO
摘要:The invention relates to a method for the preparation of a coating comprising at least one coating layer on a substrate, the method comprising the steps of a. providing monomers of the type R—(N) x -(L) m -(Câ•?C) n -(L′) o -(N′) y —R′, wherein R is a head moiety, R′ is a tail moiety, (C≡C) n is an oligoyne moiety, L and L′ are linker moieties, N and N′ independently are branched or unbranched optionally substituted C 1 -C 25 alkyl moieties optionally containing 1 to 5 heteroatoms, x, m, o, and y are independently 0 or 1, n is 4 to 12, and wherein the head moiety allows for an interaction with the surface of the substrate; b. bringing the monomers into contact with the substrate wherein the interaction of the head moieties of the monomers with the surface of the substrate induces at least a part of the monomers to align in a defined manner thereby forming a film on the surface and bringing the oligoyne moieties of the monomers into close contact with each other; c. inducing a reaction between oligoyne moieties by providing an external stimulus so as to at least partially cross-link the aligned monomers, thereby forming a coating layer on the substrate. The invention further relates to a coating obtainable according to the method of the invention, the use of a coating obtainable according to the method of the invention, a substrate comprising a coating obtainable according to the invention and the use of solid substrate. The invention further relates to a method for the synthesis ofthe monomers according to the invention.