CAS: 73278-98-5; 3-(3-(Piperidin-1-Ylmethyl)Phenoxy)Propan-1-Amine

上下游产品

CAS号73279-04-6 3-(1-哌啶基甲基)苯酚 | CAS号14753-26-5 3-氯丙胺 | CAS号6276-54-6 3-氯丙胺盐酸盐 | CAS号110-89-4 六氢吡啶 | CAS号100-83-4 间羟基苯甲醛 | CAS号107-13-1 丙烯腈 | CAS号76955-74-3 3-[3-(Piperidin... | CAS号105150-87-6 2-[3-[3-(piperi... | CAS号108441-34-5 2-chloro-N-[3-[... | CAS号93793-83-0 盐酸罗沙替丁醋酸酯 | CAS号78273-80-0 罗沙替丁 | CAS号127966-78-3 2-(2-hydroxyeth... | CAS号120958-90-9 Dalcotidine | CAS号96924-47-9 1-amino-3-[3-[3...

3-(1-哌啶基甲基)苯胺置于硫酸,Potassium Iodide,Sodium Hydroxide,Sodium Nitrite体系中,用 水,二甲基亚砜 作为反应溶剂,化学反应 20.0H,反应生成 N-3-[3-(1-哌啶甲基)-苯氧基]丙胺
参考文献:罗沙替丁醋酸酯盐酸盐的中间体3-(1-哌啶甲 基)苯酚的制备方法
标题:罗沙替丁醋酸酯盐酸盐的中间体3-(1-哌啶甲 基)苯酚的制备方法
摘要:本发明涉及一种罗沙替丁醋酸酯盐酸盐的中间体--3‑(1‑哌啶甲基)苯酚的制备方法.以间硝基苯甲醛为起始原料,在相转移催化剂作用下,经金属硼氢化物还原剂还原得到相应的苄醇;在碱存在的条件下,与有机磺酰氯类物质反应反应生成含活性的有机磺酸酯;再在碱存在的条件下与哌啶经n‑烷基化反应得到n‑取代哌啶衍生物;再将其中的硝基还原得到相应的氨基化合物;此氨基化合物在硫酸水溶液介质中经重氮化后再水解,碱化后得到3‑(1‑哌啶甲基)苯酚.本发明解决了传统合成原料间羟基苯甲醛供应不足以至合成罗沙替丁醋酸酯盐酸盐的成本大幅提高的问题,本发明方法简便而安全,各反应原料价廉易得,反应收率高,尤其是适于工业化生产3‑(1‑哌啶甲基)苯酚.

专利信息

专利号:US-4874771-A
优先权日:1988-09-06
标 题 :Ethanesulfonamide derivatives
发明人：RUSSELL RONALD K
权利人:ORTHO PHARMA CORP
摘要:The synthesis of novel ethanesulfonamide compounds is described. The novel ethanesulfonamide compounds have antisecretory activity and are used in the treatment of peptic ulcer disease.

专利号:US-5112866-A
优先权日:1988-09-06
标题:Ethanesulfonamide derivatives
发明人：RUSSELL RONALD K
权利人:ORTHO PHARMA CORP
摘要:The synthesis of novel ethanesulfonamide compounds is described. The novel ethanesulfonamide compounds have antisecretory activity and are used in the treatment of peptic ulcer disease. The intermediates used to prepare the ethanesulfonamides are useful in the treatment of osteoporosis and other bone wasting diseases.

专利号:CN-116693469-B
优先权日:2022-02-24
标题:Synthesis and purification method of roxatidine acetate hydrochloride

专利号:CN-116693469-A
优先权日:2022-02-24
标题:Synthesis and refining method of roxatidine hydrochloride acetate