CAS: 696-61-7; P-Tolylmagnesium Chloride

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CAS号106-43-4 对氯甲苯 | CAS号7439-95-4 镁标准溶液 | CAS号50670-50-3 4’-氰基-4-甲基联苯 | CAS号330-17-6 4-(三氟甲基硫代)苯甲酸 | CAS号49742-56-5 4’-甲基[1,1’-联苯]-... | CAS号352-68-1 对-(三氟甲基硫代)甲苯 | CAS号1498-79-9 9-[(4-methylphe... | CAS号53040-92-9 4-甲氧基-4-甲基-联苯 | CAS号30342-96-2 1-methyl-4-prop... | CAS号2896-10-8 Arsine,tris(4-m... | CAS号18869-29-9 4,4-二甲基-反-二苯乙烯 | CAS号21101-63-3 4-三氟甲硫基苄溴

对氯甲苯置于氢化钾,Potassium Iodide,Magnesium Chloride体系中,用 四氢呋喃 作为反应溶剂,化学反应 4.0H,以97%的收率获得产物对甲苯基氯化镁
参考文献:锰基格氏氯化物的锰催化氧化均偶联
标题:锰基格氏氯化物的锰催化氧化均偶联
摘要:使用氯化锰作为催化剂,成功实现了锰催化的芳基氯化镁的均相偶联反应生成联苯.在化学计量的1,2-二氯乙烷存在下,使用10 Mol%mncl 2作为催化剂,可以将各种芳基氯化镁有效地转化为相应的对称联芳基.由于制备格氏试剂的芳基氯化物比相应的溴化物和碘化物便宜且容易获得,因此该方法应成为制备对称联芳基的首选方法.
DOI:10.1016/j.Jorganchem.2008.12.021

专利信息

专利号:US-6340751-B1
优先权日:1998-07-24
标 题 :Process for the preparation of 4-substituted azetidinone derivatives
发明人：SAITO TAKAO; MURAYAMA TOSHIYUKI; MATSUMOTO TAKAJI; MIURA TAKASHI
权利人:TAKASAGO PERFUMERY CO LTD
摘要:Disclosed is a process for the preparation of a 4-substituted azetidinone derivative, which comprises reacting an azetidinone derivative and an amide compound in the presence of a magnesium compound such as those represented by the following formulas (II): n and (IV): n represented by the following formula (III): n n n MgR 5 R 6   (III) n n n wherein R 5 represents a C 1-12 alkyl group, a C 2-5 alkenyl group, a 5- to 8-membered alicyclic group which may be substituted by a lower C 1-4 alkyl group, a phenyl group which may be substituted by a lower C 1-4 alkyl group, a lower C 1-4 alkoxy group or a halogen atom or a benzyl group which may be substituted by a lower C 1-4 alkyl group, a lower C 1-4 alkoxy group or a halogen atom, and R 6 represents a halogen atom, a methanesulfonyloxy group, a benzenesulfonyloxy group, a p-toluenesulfonyloxy group, a trifluoromethanesulfonyloxy group, an acetoxy group which may be substituted by a halogen atom or a cyano group or an OR 7 group (R 7 representing a lower C 1-4 alkyl group, a substituted or unsubstituted phenyl group or a substituted or unsubstituted benzyl group). The process provides an industrially excellent process for the preparation of a 4-substituted azetidinone derivative which permits the selective preparation of an intermediate for the synthesis of a carbapenem antibacterial agent having a desired 1-β′ configuration.

专利号:US-4246176-A
优先权日:1979-07-05
标 题 :Synthesis of 5-aroyl-1-hydrocarbylpyrrole-2-acetic acid
发明人：ZAIKO EDWARD J
权利人:ETHYL CORP
摘要:The reaction between a 5-cyano-1-hydrocarbylpyrrole-2-acetic acid and an aryl Grignard compound to produce a ketimine salt-containing reaction intermediate is improved by performing such reaction in an aromatic ether reaction medium at a temperature above about 100° C. As compared to the previously known process, the reaction rate is markedly increased without loss of selectivity. Also, the water insolubility of aromatic ethers simplifies product work-up and recovery, reduces product losses, and facilitates solvent recovery and recycle. Preferably, the aryl Grignard reagent is prepared at the outset in tetrahydrofuran or methyl tetrahydrofuran--solvents in which such Grignard reagents are readily and safely produced. The resultant Grignard solution may then be employed in forming the aromatic ether-containing reaction medium in which the above reaction is conducted.

专利号:US-8207337-B2
优先权日:2007-01-29
标 题:Reagent for organic synthesis reaction containing organic triol borate salt
发明人：MIYAURA NORIO; YAMAMOTO YASUNORI
权利人:MIYAURA NORIO; YAMAMOTO YASUNORI; WAKO PURE CHEM IND LTD
摘要:[Problem] n To provide an organoboron compound-containing reagent for organic synthesis reactions which undergoes no trimerization with dehydration, does not necessitate activation with a base, and is stable and highly active. n [Means for Solving Problems] n The reagent for organic synthesis reactions contains an organic triol borate salt represented by any of the general formulae (I) to (III) and general formula (XVI): (wherein R 1 represents alkyl, alkenyl, etc.; R 2 represents optionally substituted alkyl, alkenyl, alkynyl, etc. or represents hydrogen; m + represents an alkaline metal ion, phosphonium ion, or given ammonium ion; M 2+ represents an alkaline earth metal; X represents halogen or alkoxide; Y represents an alkali metal ion, etc.; A represents optionally substituted methylene; and n represents an integer).

专利号:WO-2011000532-A2
优先权日:2009-07-03
标题:Method for the enantioselective addition of organometallic carbon nucleophiles to trifluoromethyl ketones and use of the method in the synthesis of hiv reverse transcriptase inhibitors

专利号:US-4474703-A
优先权日:1976-11-09
标 题 :Grignard reagents and processes for making and using them
发明人：BUJADOUX KAREL; NEYER JEAN-MARIE; HOUZEAUX JEAN-PIERRE
权利人:CHARBONNAGES STE CHIMIQUE
摘要:An organometallic halide having the formula: (RMX) (MX2)a(MR2)b (MH2)c wherein a
专利号:US-6417400-B1
优先权日:1998-03-24
标题:Methyl-phenyl derivatives, preparation method and use
发明人：DORMOY JEAN-ROBERT; GOUBET DOMINIQUE; MOREAU PATRICE
权利人:SANOFI SYNTHELABO
摘要:The present invention relates to:a) methylbiphenyl derivatives of general formula:in which R1 represents OH, C3-C7 alkyl or C3-C7 cycloalkyl, these compounds being in the form of individual isomers or mixtures thereof,b) their preparation by reaction:either of a hydroxylamine salt with an N-substituted o-(p-tolyl)benzaldimine, to give o-(p-tolyl)benzaldoximeor of an N-substituted 2-halobenzaldimine with a p-tolylmagnesium halide in the presence of an inorganic manganese derivative, to give the compounds of formula I in which R1 represents C3-C7 alkyl or C3-C7 cycloalkylc) their use for the preparation of o-(p-tolyl)-benzonitrile, which is an intermediate in the synthesis of medicinal products.