CAS: 6908-41-4; Methyl 4-(Hydroxymethyl)Benzoate

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CAS号1571-08-0 对甲酰基苯甲酸甲酯 | CAS号7377-26-6 4-氯甲酰基苯甲酸甲酯 | CAS号1679-64-7 对苯二甲酸单甲酯 | CAS号120-61-6 对苯二甲酸二甲酯 | CAS号106727-85-9 methyl 4-((phen... | CAS号104292-97-9 methyl 4-[(tetr... | CAS号67-56-1 甲醇 | CAS号3006-96-0 4-羟甲基苯甲酸 | CAS号2417-72-3 4-溴甲基苯甲酸甲酯 | CAS号105095-22-5 methyl 4-[(4-ni... | CAS号34040-64-7 4-氯甲基苯甲酸甲酯 | CAS号99-75-2 对甲基苯甲酸甲酯 | CAS号93-58-3 苯甲酸甲酯 | CAS号24313-71-1 Benzoic acid, 4... | CAS号27548-25-0 4-(乙酰氧基甲基)苯甲酸甲酯 | CAS号3006-96-0 4-羟甲基苯甲酸 | CAS号1571-08-0 对甲酰基苯甲酸甲酯 | CAS号67-56-1 甲醇 | CAS号3034-86-4 4-乙炔基苯甲酸甲酯

对甲基苯甲酸甲酯置于三甲基硅乙酸酯,水,Copper (I) Acetate,三氟乙酸体系中,用 四氢呋喃,二氯甲烷 作为反应溶剂,化学反应 26.0H,反应生成 4-(羟甲基)苯甲酸甲酯
参考文献:C-H 氧化合成苯甲醇
标题:C-H 氧化合成苯甲醇
摘要:由于醇进一步氧化为酮的倾向很高,选择性亚甲基c-H氧化合成具有广泛范围和官能团耐受性的醇具有挑战性.在这里,我们报道了使用双(甲磺酰基)过氧化物作为氧化剂选择性合成苄醇.我们试图为单氧化的选择性提供一个基本原理,这与之前的工作不同;质子耦合电子转移机制(pcet)可以解释反应性的差异.我们预计我们的方法将有助于药物和农用化学品的发现.
DOI:10.1021/jacs.9B09496

专利信息

专利号:US-8461298-B2
优先权日:2004-11-01
标 题:Compositions and methods for modification of biomolecules
发明人：BERTOZZI CAROLYN R; AGARD NICHOLAS J; PRESCHER JENNIFER A; BASKIN JEREMY MICHAEL
权利人:BERTOZZI CAROLYN R; AGARD NICHOLAS J; PRESCHER JENNIFER A; BASKIN JEREMY MICHAEL; UNIV CALIFORNIA
摘要:The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).

专利号:US-9260371-B2
优先权日:2004-11-01
标题:Compositions and methods for modification of biomolecules
发明人：BERTOZZI CAROLYN RUTH; AGARD NICHOLAS J; PRESCHER JENNIFER A; BASKIN JEREMY MICHAEL; SLETTEN ELLEN MAY
权利人:UNIV CALIFORNIA
摘要:The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).

专利号:US-9422232-B2
优先权日:2009-07-09
标题:Reductive release probes containing a chemoselectively cleavable α-azidoether linker and methods of use thereof
发明人：FRANZINI RAPHAEL M; KOOL ERIC TODD
权利人:FRANZINI RAPHAEL M; KOOL ERIC TODD; UNIV LELAND STANFORD JUNIOR
摘要:Probes comprising one or more selectively cleavable α-azidoether moieties are provided; and linkers comprising the one or more selectively cleavable α-azidoether moieties. The α-azidoether moiety will undergo a Staudinger reaction with a suitable reducing agent, resulting in cleavage. The probes find use in a variety of detection assays, e.g. specific polynucleotide binding assays, polypeptide binding assays, etc. The cleavable linkers are suitable for synthetic reactions, e.g. to prepare probes of the invention; in the synthesis of cleavable peptide conjugates; and the like.

专利号:US-5616698-A
优先权日:1994-01-10
标题:Polymer-supported solution synthesis of oligosaccharides
发明人：KREPINSKY JIRI J; DOUGLAS STEPHEN P; WHITFIELD DENNIS M
权利人:UNIV TORONTO
摘要:The present invention provides improved syntheses of oligosacchairdes. In accordance with preferred embodiments, anomeric specificity in such syntheses can be attained using polymer-supported liquid synthetic design with certain novel diether linkers. The present invention also provides novel strategies for capping imcompletely glycosylated hydroxyls.

专利号:US-6417396-B1
优先权日:1997-09-24
标 题 :Quenching reagents for solution phase synthesis
发明人：NIKAM SHAM
权利人:WARNER LAMBERT CO
摘要:A method for enhancing the purity of a desired compound comprising:Step (a) treating a crude reaction product which contains at least one desired compound, unreacted starting materials and/or byproducts with at least one bifunctional quenching agent that is capable of selective covalent reaction with unwanted byproducts, or excess reagents;Step (b) allowing the quenching agent to covalently react with unreacted starting materials and/or byproducts to afford a derivatized compound of the quenching agent: andStep (c) isolating the desired compound is described as well as novel quenching agents and methods for their use in the rapid purification of synthetic intermediates and products in synthesis, combinatorial chemistry, and automated organic synthesis.

专利号:US-9603951-B2
优先权日:2010-02-08
标题 :Methods and apparatus for synthesizing imaging agents, and intermediates thereof
发明人：LAZEWATSKY JOEL; DEVINE MARYBETH
权利人:LANTHEUS MEDICAL IMAGING INC
摘要:The present invention generally relates to methods and system for the synthesis of imaging agents, and precursors thereof. The methods may exhibit improved yields and may allow for the large-scale synthesis of imaging agents, including imaging agents comprising a radioisotope (e.g., 18 F). Various embodiments of the invention may be useful as sensors, diagnostic tools, and the like. In some cases, methods for evaluating perfusion, including myocardial perfusion, are provided. Synthetic methods of the invention have also been incorporated into an automated synthesis unit to prepare and purify imaging agents that comprise a radioisotope. In some embodiments, the present invention provides a novel methods and systems comprising imaging agent 1, including methods of imaging in a subject comprising administering a composition comprising imaging agent 1 to a subject by injection, infusion, or any other known method, and imaging the area of the subject wherein the event of interest is located.