CAS: 68576-86-3; 1-(4-(2-Methoxyphenyl)Piperazin-1-yl)-3-(3,4,5-Trimethoxyphenoxy)Propan-2-Ol

上下游产品

1-(2-Methoxyphenyl)piperazine 1-(3,4,5-trimethoxyphenoxy)-2,3-epoxypropane 3,4,5-trimethoxyphenol 2-hydroxy-3-[4-(o-methoxyphenyl)-1-piperazinyl]propyl chloridepropane1-(3,4,5-trimethoxyphenoxy)-2-(nicotinoyloxy)-3-4-(2-methoxyphenyl)piperazinylpropane -3-propane1-(3,4,5-trimethoxyphenoxy)-2-(3,4,5-trimethoxybenzoyl)oxy-3-4-(2-methoxyphenyl)piperazinylpropane

📜3,4,5-三甲氧基苯酚置于sodium Hydroxide体系中,用 异丙醇 作为反应溶剂,化学反应 6.0H,反应生成 恩西拉嗪
参考文献:Chemistry And Pharmacology Of The Non-Benzodiazepine Anxiolytic Enciprazine And Related Compounds
标题:Chemistry And Pharmacology Of The Non-Benzodiazepine Anxiolytic Enciprazine And Related Compounds
摘要:In The Course Of Studies On Tranquilizers,New Non-Benzodiazepine-Like Compounds Were Synthesized. These Are 1-(3,4,5-Trimethoxyphenoxy)-3-[4-(2-Methoxyphenyl)Piperazinyl]Prop An-2-Ol (Inn: Enciprazine) And Derivatives Thereof Which Were Screened Pharmacologically In Order To Evaluate Their Central Nervous System Activity. Compounds With Marked Antiaggressive And Anxiolytic Properties But Without Dependence Potential Could Be Detected. Enciprazine Was Selected For Clinical Investigations.
DOI:10.1021/jm00173A012

专利信息

专利号:US-7749985-B2
优先权日:2006-09-15
标 题 :Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
发明人：GALLOP MARK A; XU FENG; PHAN THU; DILIP USHA; PENG GE
权利人:XENOPORT INC
摘要:Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of making acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of using acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, and pharmaceutical compositions comprising acyloxyalkyl carbamate prodrugs 3-aminopropylphosphinic acid and analogs thereof for treating diseases or disorders such as mild cognitive impairment, cognitive impairment associated with Alzheimer's disease Alzheimer's disease, depression, anxiety, and epilepsy are disclosed. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, which are suitable for oral administration and sustained release oral dosage forms are also disclosed.

专利号:US-2008146526-A1
优先权日:2006-09-15
标 题 :Acyloxyalkyl carbamate prodrugs, methods of synthesis and use

专利号:US-2009286759-A1
优先权日:2006-09-15
标题:Acyloxyalkyl carbamate prodrugs, methods of synthesis and use

专利号:WO-2008033572-A1
优先权日:2006-09-15
标题:Acyloxyalkyl carbamate prodrugs, methods of synthesis and use

专利号:US-7585996-B2
优先权日:2006-09-15
标 题 :Acyloxyalkyl carbamate prodrugs, methods of synthesis and use