CAS: 6736-85-2; Catalpin
该化合物是主要来自加泰罗尼亚植物的甘蓝表面化合物,特别是加泰罗尼亚大无碘类植物,其特点是结构结构,由糖浆组成,与苯球类甘油相连,有助于其生物活动;加泰罗尼亚州表现出抗氧化特性,并研究其潜在的治疗作用,包括抗炎和...
- 英文名称Catalpin
- 中文名称梓苷
- IUPAC名称(1aS,1bS,2S,5aR,6S,6aS)-1a-(hydroxymethyl)-2-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1a,1b,2,5a,6,6a-hexahydrooxireno[2',3':4,5]cyclopenta[1,2-c]pyran-6-yl 4-hydroxybenzoate
- 其它别名-(hydroxymethyl)oxireno(4,5)cyclopenta(1,2-c)pyran-2-yl,(1as-(1a-alpha,1b-beta; ,2-beta,5a-beta,6-beta,6a-alpha))-; beta-d-glucopyranoside,1a,1b,2,5a,6,6a-hexahydro-6-((4-hydroxybenzoyl)oxy)-1a; hydroxybenzoylcatalpol; CATALPIN; CATALPOSIDE; 1a(S)alpha,1bbeta,2beta,5abeta,6beta,6a.alpha.-hexahydro-6-[(4-hydroxybenzoyl)oxy]-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl beta-D-glucopyranoside; 1aβ,1bα,2β,5aα,6β,6aβ-Hexahydro-6-[(4-hydroxybenzoyl)oxy]-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl β-D-glucopyranoside
- CAS编号6736-85-2
- MFCD编号:MFCD28015867
- EINECS号:229-789-1
- FDA UNII编号:7KD7K3964H
- 分子式:C22H26O12分子量:482.43
- 产品CID: 1656412
- 产品分类天然产物 → 环烯醚萜衍生物
物理性质
- 熔点215-216.5°
- 沸点766.3±60.0 °C at 760 mmHg
- 闪点266.7±26.4 °C
- 密度1.7±0.1 g/cm3
- PH:D23.2 -184° (c = 0.87 in methanol)
- pKa:8.03±0.15(预测)
- PSA:187.9
- LogP:-2.18
- 折射率1.696
- 蒸汽压0.0±2.7 mmHg at 25°C
- 溶解性Soluble In Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,Etc.
- 外观形态白色至黄色粉末
- 储存条件-20°C
- 产品应用该化合物是孤立于CATALPA OVATA类原产植物的离子体生产厂的化合物,加泰尔州已证明拥有抗微生物,抗地形和抗炎特性,并发现抑制了肿瘤细胞因子-Α(TNF-Α),内列因-1贝塔和内列伊因-6(IL-6)的生产,以及在RAW 264.7中用脂性沙律(LPS)激活的核因子 KB(NF/KB) .
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2905122000-异丙醇
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供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Ryu HW, Lee SU, Lee S, Song HH, Son TH, Kim YU, Yuk HJ, Ro H, Lee CK, Hong ST, Oh SR. 3-Methoxy-catalposide inhibits inflammatory effects in lipopolysaccharide-stimulated RAW264.7 macrophages. Cytokine. 2017 Mar;91:57-64. doi: 10.1016/j.cyto.2016.12.006. Epub 2016 Dec 21. 145(1):46-54. doi: 10.1016/s0378-4274(03)00268-6. 422(4):568-72. doi: 10.1016/j.bbrc.2012.05.025. Epub 2012 May 11. 11(7):355. doi: 10.3390/pharmaceutics11070355.
5: Kim SW, Choi SC, Choi EY, Kim KS, Oh JM, Lee HJ, Oh HM, Kim S, Oh BS, Kimm KC, Lee MH, Seo GS, Kim TH, Oh HC, Woo WH, Kim YS, Pae HO, Park DS, Chung HT, Jun CD. Catalposide, a compound isolated from catalpa ovata, attenuates induction of intestinal epithelial proinflammatory gene expression and reduces the severity of trinitrobenzene sulfonic Acid-induced colitis in mice. Inflamm Bowel Dis. 2004 Sep;10(5):564-72. doi: 10.1097/00054725-200409000-00010. 68(8):685-9. doi: 10.1055/s-2002-33810.
9:643-53. doi: 10.2147/DDDT.S75400.
合成参考文献
摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
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