CAS: 607-68-1; 2,4-Dichloroquinazoline

上下游产品

CAS号86-96-4 2,4-喹唑啉二酮 | CAS号32315-10-9 三光气 | CAS号1885-29-6 2-氨基苯甲腈 | CAS号120-94-5 1-甲基吡咯烷 | CAS号607-69-2 2-氯喹唑啉-4-酮 | CAS号503-38-8 氯甲酸三氯甲酯 | CAS号118-92-3 邻氨基苯甲酸 | CAS号52851-41-9 喹啉-2,4(1H,3H)-二酮 | CAS号7335-06-0 1-乙基吡咯烷 | CAS号7335-07-1 N-n-propylpyrro... | CAS号59870-43-8 2-氯喹唑啉-4-胺 | CAS号491-36-1 4-Quinazolinone | CAS号1804-50-8 2-氯-4-(吡咯烷-1-基)喹唑啉 | CAS号35691-09-9 2-chloro-N,N-di... | CAS号1899-48-5 2,4-二氨基喹唑啉 | CAS号253-82-7 喹唑啉 | CAS号86-96-4 2,4-喹唑啉二酮 | CAS号607-69-2 2-氯喹唑啉-4-酮 | CAS号703-63-9 2,4-二甲基喹唑啉 | CAS号6141-13-5 2-氯喹唑啉

2,2,2-Trifluoro-N-(2-Iodophenyl)Acetamide置于potassium Carbonate体系中,用 甲醇,N,N-二甲基甲酰胺,乙腈 作为反应溶剂,化学反应 24.5H,反应生成 2,4-二氯喹唑啉
参考文献:乙腈介导的 2-乙炔苯胺合成 2,4-二氯喹啉和邻氨基苯甲腈合成 2,4-二氯喹唑啉
标题:乙腈介导的 2-乙炔苯胺合成 2,4-二氯喹啉和邻氨基苯甲腈合成 2,4-二氯喹唑啉
摘要:2,4-二氯喹啉和 2,4-二氯喹唑啉分别由 2-乙炔基苯胺和邻氨基苯甲腈合成,在乙腈中使用双光气并在 130 oc 或 150 oc 下加热 12 小时.该反应用于合成 4,6-二氯吡唑并[3,4-D]嘧啶(二氯-9H-异嘌呤).还描述了假定的机制.
DOI:10.1055/s-2005-922790

专利信息

专利号:US-5304647-A
优先权日:1988-02-09
标题:Method of preparation of halogenated diazines
发明人：STREKOWSKI LUCJAN; MOKROSZ MARIA; HARDEN DONALD B
权利人:UNIV GEORGIA STATE
摘要:A method of preparation of substituted halogenodiazines which are useful as intermediates in the synthesis of novel unfused heterobicyclic compounds, and the products thereof. The reaction consists of the addition of an organolithium reagent with subsequent dehydrogenation of the addition product. The reaction takes place in one reaction vessel, without isolation of the substituted halogenodihydrodiazine intermediate. The reactions proceed at moderate temperature and in a short amount of time, which decreases the probability of side reactions and increases yield. Furthermore, the workup step is conducted under two-phase conditions to prevent hydrolysis of the substituted halogenodiazine to a substituted hydroxydiazine. The method is easy, efficient and results in a high yield of product. The substituted halogenodiazines are used as intermediates in the synthesis of unfused heterobicyclic compounds containing an aromatic moiety, diazine, and another aromatic moiety, such as thiophene, benzene, or naphthalene, which have biological activity.

专利号:US-4963676-A
优先权日:1988-02-09
标题 :Di-substituted phthalazines
发明人：STREKOWSKI LUCJAN; MOKROSZ MARIA; HARDEN DONALD B
权利人:UNIV GEORGIA STATE
摘要:A method of preparation of substituted halogenodiazines which are useful as intermediates in the synthesis of novel unfused heterobicyclic compounds, and the products thereof. The reaction consists of the addition of an organolithium reagent with subsequent dehydrogenation of the addition product. The reaction takes place in one reaction vessel, without isolation of the substituted halogenodihydrodiazine intermediate. The reactions proceed at moderate temperature and in a short amount of time, which decreases the probability of side reactions and increases yield. Furthermore, the workup step is conducted under two-phase conditions to prevent hydrolysis of the substituted halogenodiazine to a substituted hydroxydiazine. The method is easy, efficient and results in a high yield of product. The substituted halogenodiazines are used as intermediates in the synthesis of novel unfused heterobicyclic compounds containing an aromatic moiety, diazine, and another aromatic moiety, such as thiophene, benzene, or naphthalene, which have biological activity.

专利号:CN-109485610-A
优先权日:2019-01-02
标 题 :One-pot method for the synthesis of 2-chloro-4-phenylquinazoline

专利号:CN-115417860-B
优先权日:2020-08-03
标 题 :A kind of quinazoline derivative with anti-tumor activity and its synthesis method and use

专利号:EP-1370553-B1
优先权日:2001-03-23
标 题 :Rho-kinase inhibitors
发明人：NAGARATHNAM DHANAPALAN; ASGARI DAVOUD; SHAO JIANXING; LIU XIAO-GAO; KHIRE UDAY; WANG CHUNGUANG; HART BARRY; BOYER STEPHEN; WEBER OLAF; LYNCH MARK; BANKSTON DONALD
权利人:BAYER AG
摘要:Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

专利号:CN-116178284-A
优先权日:2023-02-24
标题:Synthesis method of 2, 4-dihydroxyquinazoline and derivatives thereof