📜乳酸甲酯,C.I.酸性橙108 反应生成 乳酰胺 Mea 参考文献:Preparation Of N-Substituted Lactamides By Aminolysis Of Methyl Lactate2,3 标题:Preparation Of N-Substituted Lactamides By Aminolysis Of Methyl Lactate2,3 摘要: DOI:10.1021/jo01148A013
专利号:US-4627968-A 优先权日:1984-09-10 标 题 :Synthesis of crystalline aluminosilicate with alkylurea or alkylthiourea 发明人:KAI TADASHI 权利人:ASAHI CHEMICAL IND 摘要:In the synthesis of a crystalline aluminosilicate by heating an aqueous mixture containing a silica source, an alumina source and an alkali metal source, at least one compound selected from lower alkylureas and lower alkylthioureas is permitted to co-exist with the mixture.
专利号:US-2005069551-A1 优先权日:2002-03-08 标题 :Cytotoxic compound-protein conjugates as suppressors of tumor growth and angiogenesis 发明人:SHOJI MAMORU; SNYDER JAMES P; LIOTTA DENNIS C; SUN AIMING 权利人:UNIV EMORY 摘要:Compositions and methods are provided for delivering cytotoxic compounds, such as natural curcumoids and synthetic curcumin analogs, specifically to cancer cells and to blood vessels that nourish solid tumors. The compositions include a cytotoxic drug tethered to a protein, such as factor VIIa, which can bind with high affinity to a receptor, such as tissue factor, expressed on the surface of cancer cells and vascular endothelial cells within the tumor microenvironment. Upon binding, the drug-protein-receptor complex is endocytosed and the drug is subsequently liberated inside the target cell via proteolytic cleavage. The compositions and methods may increase the efficacy of the cytotoxic agets and decrease their side effects by delivering the agents to specific target cells, such as cancer cells, vascular endothelial cells in a tumor, and metastatic foci anywhere in the body, providing the target cells express surface bound tissue factor. Additionally, methods of synthesis of cytotoxic compound-protein conjugates are provided, for example, curcuminoid-tether-linker-factor VIIa composition, as well as pharmaceutically acceptable compositions and methods for delivering a therapeutically-effective amount of a cytotoxic compound-protein conjugate together with one or more pharmaceutically acceptable carriers (additives) and/or diluents to an animal or human patient.
专利号:US-7598403-B2 优先权日:2003-05-16 标 题 :Synthesis of chromanones 发明人:SALVATORE BRIAN A; SOLIS FERDINAND C 权利人:UNIV SOUTH CAROLINA RES FOUND 摘要:Processes for the preparation of biologically active chromanones are disclosed, including processes for the preparation of intermediates useful in the preparation of the biologically active chromanones. The chromanones and the intermediates disclosed herein may be useful for a variety of therapies, including the treatment of various cancers and the treatment of inflammation and inflammation related disorders.
专利号:US-2019276389-A1 优先权日:2015-12-18 标题:Synthesis of aryl cyclohexane ester derivatives useful as sensates in consumer products 发明人:WOS JOHN AUGUST; YELM KENNETH EDWARD; BUNKE GREGORY MARK; FREDERICK HEATH ALAN; REILLY MICHAEL; HAUGHT JOHN CHRISTIAN; SREEKRISHNA KOTI TATACHAR; LIN YAKANG 权利人:PROCTER & GAMBLE 摘要:Personal care compositions, such as oral care and skin care compositions containing a flavor/perfume system comprising one or more coolants. The pleasant cool sensation provided by a coolant is enhanced in terms of quicker onset, greater intensity, impact or longer duration, which improves appeal and acceptability of the compositions to consumers.
专利号:US-2007203214-A1 优先权日:2003-05-16 标 题 :Synthesis Of Chromanones
专利号:AU-2016371908-A1 优先权日:2015-12-18 标题 :Synthesis of cyclohexane ester derivatives useful as sensates in consumer products