CAS: 50594-31-5; 4,5-Dichloro-2-Nitrobenzotrifluoride

3,4-二氯三氟甲苯置于硫酸,硝酸体系中,化学反应 120.0H,反应生成 3,4-二氯-5-硝基三氟甲苯,3,4-二氯-6-硝基三氟甲苯
参考文献:Design And Synthesis Of New Mitochondrial Cytotoxin N-Thiadiazolylanilines That Inhibit Tumor Cell Growth
标题:Design And Synthesis Of New Mitochondrial Cytotoxin N-Thiadiazolylanilines That Inhibit Tumor Cell Growth
摘要:New N-Thiadiazolylanilines Were Designed And Synthesized To Develop Mitochondrial Cytotoxins Superior To Sf 6847. The Mitochondrial Cytotoxin N-Thiadiazolylanilines,Tx-108 And Tx-109,Inhibited Emt6/ku Mammary Sarcoma Cell Growth At A Low Micromolar Concentration. Their Inhibitory Activities Were Parallel To Their Mitochondrial Cytotoxicity,Such As Uncoupling Oxidative Phosphorylation And Inhibiting Atp Synthesis. This Report Also Supports The Notion That The Inhibition Of Tumor Cell Growth Of Inhibitor Of Protein Tyrosine Kinase Ag17,Which Is Identical To Sf 6847,May Be Due To Its Mitochondrial Cytotoxicity.
DOI:10.1016/0968-0896(95)00182-4

专利信息

专利号:US-4876376-A
优先权日:1983-06-23
标题 :Process for the halogenation, nitration and fluorination of aromatic derivatives
发明人：DESBOIS MICHAEL; DISDIER CAMILLE
权利人:RHONE POULENC SPEC CHIM
摘要:A process for the halogenation (bromination or chlorination)/nitration/fluorination of aromatic derivatives substituted by at least one group containing a halogenoalkyl unit. The aromatic derivative is reacted with a halogen and a nitrating agent in liquid hydrofluoric acid. The products obtained are useful as intermediates for the synthesis of compounds having a plant-protecting or pharmaceutical activity.