CAS: 4332-97-2; 3-Phenyl-5-(Phenylmethyl)-2-Thioxo-4-Imidazolidinone

该化合物是一种环环化合物,其特点是其极离子子素核心结构,其特点是三氯基(硫磺原子双壳碳)和苯基替代成分.该化合物通常具有有机溶剂中中溶性以及由于存在可参与各种化学反应,包括核毒攻击的异氧组而具有的潜在再活性等特性.苯基化合物助长其缺水特性,并可能影响其生物活动,使其对药用化学感兴趣.此外,氨焦离子素框架因其潜在的危害性,包括抗微生物和抗炎活动,而众所周知,该化合物的稳定性,再活性和与生物系统的相互作用可因其特定环境和条件而有所变化,使其成为对合成化学和药用化学领域进行进一步研究的主体.

结构式图片

物理性质

MSDS等安全信息

    上下游产品

    CAS号150-30-1 DL-苯丙氨酸 | CAS号701-73-5 METHYL DITHI°CA... | CAS号63-91-2 L-苯丙氨酸 | CAS号103-72-0 异硫氰酸苯酯 | CAS号4530-18-1 N-甲基-N-叔丁氧羰基-D-苯丙氨酸 | CAS号32832-07-8 5-benzylidene-3... | CAS号103-72-0 异硫氰酸苯酯 | CAS号716-79-0 2-苯基苯并咪唑

    合成工艺路线路线简述

      📜N-甲基-N-叔丁氧羰基-D-苯丙氨酸置于4-二甲氨基吡啶,二乙胺,N,N-二异丙基乙胺,N,N'-二环己基碳二亚胺体系中,用 甲醇,二氯甲烷,乙腈 作为反应溶剂,化学反应 27.25H,反应生成 苯基硫代乙内酰脲-苯丙氨酸
      参考文献:Microwave-Assisted Synthesis Of 3,5-Disubstituted Thiohydantoins Using Functional Ionic Liquid As Soluble Support
      标题:Microwave-Assisted Synthesis Of 3,5-Disubstituted Thiohydantoins Using Functional Ionic Liquid As Soluble Support
      摘要:A New Approach For The Syntheses Of 3,5-Disubstituted Thiohydantoins Was Described Using Functionalized Ionic Liquid As Soluble Support. The Products Were Obtained In Good Yields And Purities After Cyclization-Cleavage From The Ionic-Liquid-Supported Under Microwave Irradiation,The Ionic-Liquid-Supported Species Can There Be Purified From The Reaction Mixture By Simple Washing,And No Chromatographic Purification Were Needed During The Synthesis.
      DOI:10.3987/com-10-12086

      海关参考信息

      其他信息查阅

      供应商参考报价(招募中)

      品牌试剂参考报价(招募中)

      实用工具

      ⚠️全国化工行业净网倡议书
      📋制造商识别码
      📖 海关编码查询
      📝MSDS生成器

      📌 第三方产品分析报告

      ✅ COA系统入驻 | 共享模式

      主要参考文献

      参考标题:Base Controlled Three-Component Regioselective Synthesis Of 2-Imino Thiazolines And 2-Thioxoimidazolin-4-Ones
      作者:Indrajeet J. Barve,Wong-Jin Chang,Yen-Tzu Lin,Tushar Ulhas Thikekar,Chung-Ming Sun |发布日期:2019.4.8
      摘要:Base-Controlled Regioselective Synthesis Of 2-Imino Thiazolines And 2-Thioxoimidazolin-4-Ones Was Achieved To Use A One-Pot Reaction Between Chiral Amino Esters, Isothiocyanates, And α-Bromoketones/alkyl Halides. This Three-Component Coupling Reaction In Acetonitrile Provides 2-Imino Thiazolines, Whereas The Formation Of 2-Thioxoimidazolin-4-Ones Was Observed Under Basic Conditions At Ambient Temperature.

      合成参考文献


      参考文献:10.1016/j.jbc.2022.102228
      摘要:Scoles DR, Gandelman M, Paul S, Dexheimer T, Dansithong W, Figueroa KP, Pflieger LT, Redlin S, Kales SC, Sun H, Maloney D, Damoiseaux R, Henderson MJ, Simeonov A, Jadhav A, Pulst SM. A quantitative high-throughput screen identifies compounds that lower expression of the SCA2-and ALS-associated gene ATXN2. Journal of Biological Chemistry. 2022 Aug;298(8):102228. doi: 10.1016/j.jbc.2022.102228.
      📝 需求与反馈
      尽可能描述清楚需求与问题信息
      ×

      通知