CAS: 40031-31-0; 1,3,4-Trihydroxybutan-2-One

📜Erythritol置于[(Neocuproine)Pd(Oac)]2(Otf)2体系中,用 水,乙腈 作为反应溶剂,化学反应 24.0H,以74%的收率获得产物赤藓酮糖
参考文献:多元醇的化学选择性 Pd 催化氧化:合成范围和机理研究
标题:多元醇的化学选择性 Pd 催化氧化:合成范围和机理研究
摘要:在温和的反应条件下,未保护的邻位多元醇与 [(Neocuproine)Pd(Oac)]2(Otf)2 (1)(neocuproine = 2,9-二甲基-1,10-菲咯啉)的区域和化学选择性氧化很容易发生反应生成α-羟基酮.邻二醇的氧化比伯醇和仲醇的氧化速度更快,选择性更强;邻位 1,2-二醇被选择性氧化为羟基酮,而伯醇优先于仲醇氧化.1,5-二醇的氧化内酯化产生环内酯.在 10 克规模的氧化反应中,可以使用低至 0.12 Mol% 的催化剂负载量.在多元醇 (S,S)-1,2,3,4-四羟基丁烷 [(S,S)-苏糖醇] 到 (S)-赤藓酮糖的化学选择性和立体定向氧化过程中,该催化剂体系的卓越选择性是显而易见的.机械的,动力学和理论研究表明,伯醇和仲醇的氧化速率定律与二醇不同.密度泛函理论计算支持以下结论:β-氢化物消除产生羟基酮是邻二醇氧化的产物决定因素,而对于伯醇和仲醇,有利于伯醇盐的预平
DOI:10.1021/ja4008694

专利信息

专利号:US-5200516-A
优先权日:1990-02-16
标 题:Synthesis of sugars from substituted and unsubstituted arene diols
发明人：HUDLICKY TOMAS
权利人:VIRGINIA TECH INTELL PROP
摘要:There are disclosed processes for the synthesis of substituted and unsubstituted arene diols useful in the further synthesis of sugars, sugar derivatives, chiral synthons or amino acids.

专利号:US-5939304-A
优先权日:1997-06-05
标题:Method for synthesis of anhydrothrombin
发明人：SUZUKI TOYOAKI; HOSOKAWA KAZUYA; NAGATA MASANORI
权利人:FUJIMORI KOGYO CO
摘要:A method for a synthesis of anhydrothrombin is provided which features a short process, an easy procedure, and high yields. n The method comprises n (A) a step of causing an active serine residue site of thrombin to react with an inhibitor, n (B) a step of performing an alkali treatment at a pH of not less than 11, and n (C) a step of performing an operation of recovery, and carries out these steps sequentially in the order mentioned, and is characterized by causing at least the step of performing the operation of recovery to proceed in the presence of at least one compound selected from the group consisting of polyhydric alcohols and saccharides, and a salt or an amphoteric electrolyte.

专利号:US-5945529-A
优先权日:1996-07-19
标题:Synthesis of polyol fatty acid polyesters using column with inert gas stripping
发明人：CORRIGAN PATRICK JOSEPH; KENNEALLY COREY JAMES; GRANBERG ERIC PAUL
权利人:PROCTER & GAMBLE
摘要:Processes for the synthesis of polyol fatty acid polyester by transesterification of a polyol comprise reacting polyol with a first portion of fatty acid lower alkyl ester to provide a first step reaction product in which substantially all of the polyol is reacted with at least one fatty acid lower alkyl ester. The processes then employ a multistage column providing substantial plug flow of liquid therein for further transesterification of the first step reaction product. Partially esterified polyol, a second portion of fatty acid lower alkyl ester and catalyst are fed to the column to form a mixture and cause further transesterification of the partially esterified polyol and fatty acid lower alkyl ester, with lower alkyl alcohol being formed as a by product. The resulting liquid mixture of reactants and product is passed in a first direction between adjacent stages through the column for further reaction of partially esterified polyol with fatty acid lower alkyl ester. An inert stripping or sparging gas is fed through the column in a second direction between adjacent stages, counter current to the flow of the liquid mixture between adjacent stages in the first direction, with radial shear agitation. The lower alkyl alcohol by-product of the polyol-fatty acid lower alkyl ester reaction is transferred from the liquid mixture to the inert gas.

专利号:US-10973847-B2
优先权日:2017-06-30
标题 :Core-to-surface polymerization for the synthesis of star polymers and uses thereof
发明人：JOHNSON JEREMIAH A; GOLDER MATTHEW R
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Disclosed are methods, compositions, reagents, systems, and kits to prepare star polymers, as well as compositions and uses thereof. Various embodiments show that synthesis of these polymers contain low metal concentration to provide polymers for diverse biomedical applications including in vivo applications.

专利号:US-6620952-B1
优先权日:1999-01-28
标题:Synthesis of polyol fatty acid polyesters
发明人：CORRIGAN PATRICK JOSEPH
权利人:PROCTER & GAMBLE
摘要:Processes for the synthesis of polyol fatty acid polyester by transesterification of a polyol comprise reacting polyol with a first portion of fatty acid lower alkyl ester to provide a first step reaction product in which substantially all of the polyol is reacted with at least one fatty acid lower alkyl ester. The process then employs a multistage column for further transesterification of the first step reaction product. Partially esterified polyol, a second portion of fatty acid lower alkyl ester and catalyst are fed to the column to form a mixture and cause further transesterification of the partially esterified polyol and fatty acid lower alkyl ester, with lower alkyl alcohol being formed as a by product. The resulting liquid mixture of reactants and product is passed in a first direction between adjacent stages through the column for further reaction of partially esterified polyol with fatty acid lower alkyl ester. An inert sparging gas is fed through the column in a second direction between adjacent stages, counter current to the flow of the liquid mixture between adjacent stages in the first direction. The inert gas is directed through the liquid mixture to provide gas induce turbulence, such that the column reactor has a column ratio of at least 0.4/hour.

专利号:US-7193077-B2
优先权日:2003-08-30
标 题 :Exocyclic amine triaryl methyl protecting groups in two-step polynucleotide synthesis
发明人：DELLINGER DOUGLAS J; SIERZCHALA AGNIESZKA B; CARUTHERS MARVIN H
权利人:AGILENT TECHNOLOGIES INC
摘要:Precursors for use in the synthesis of polynucleotides and methods of using the precursors in synthesizing polynucleotides are disclosed. The precursors include a heterocyclic base having an exocyclic amine group and a substituted or unsubstituted triaryl methyl protecting group bound to the exocyclic amine group.