CAS: 387353-77-7; Methyl (S,E)-5-Chloro-2-Isopropylpent-4-Enoate

相似化合物

1575-71-9 324519-66-6 72143-24-9

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CAS号67-56-1 甲醇 | CAS号1350705-33-7 (S,E)-5-chloro-... | CAS号87953-16-0 (E)-5-氯-2-异丙基-4-戊烯酸 | CAS号18107-18-1 (三甲硅烷)重氮甲烷 | CAS号324519-66-6 阿利克仑-3 | CAS号72651-95-7 2,2-二甲基-5-异亚丙基-... | CAS号705259-97-8 2-[(2E)-3-氯-2-丙... | CAS号51122-91-9 异丙基丙二酸二甲酯 | CAS号324519-68-8 阿利克仑-4 | CAS号387353-71-1 (2S,4E,7R)-7-[4... | CAS号173334-57-1 阿利吉仑 | CAS号324763-47-5 (αS,γS,δS,ζS)-N...

📜Methyl (4E)-5-Chloro-2-Isopropyl-4-Pentenoate置于esterase V Enzime Sodium Hydroxide体系中,化学反应 24.0H,以44%的收率获得(2S,4E)-5-氯-2-异丙基戊-4-烯酸甲酯
参考文献: Process For Preparing Aliskiren And Its Intermediates[fr] Procédé Pour Préparer L'Aliskirène Et Ses Intermédiaires
标题: Process For Preparing Aliskiren And Its Intermediates[fr] Procédé Pour Préparer L'Aliskirène Et Ses Intermédiaires

专利信息

专利号:WO-2011148392-A1
优先权日:2010-05-28
标题 :Process for the preparation of (2s,4s,5s,7s)-n-(2-carbamyl-2- methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3- methoxypropoxy)phenyl]-octanamide hemifumarate and its intermediates thereof
发明人：SATYANARAYANA REDDY MANNE; THIRUMALAI RAJAN SRINIVASAN; ESWARAIAH SAJJA; VENKAT REDDY GHOJALA; RAMA SUBBA REDDY KARAMALA; SAHADEVA REDDY MARAMREDDY
权利人:MSN LAB LTD; SATYANARAYANA REDDY MANNE; THIRUMALAI RAJAN SRINIVASAN; ESWARAIAH SAJJA; VENKAT REDDY GHOJALA; RAMA SUBBA REDDY KARAMALA; SAHADEVA REDDY MARAMREDDY
摘要:The present invention relates to a process for the preparation of (2S,4S,5S,7S)-N-(2- Carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3-methoxy propoxy )phenyl]-octanamide compound of formula- 1 and its pharmaceutically acceptable salts thereof. Further, relates to the processes for the preparation of (R)-4-(2-(halomethyl)-3- methylbutyl)-l-methoxy-2-(3-methoxypropoxy) benzene and (R)-2-(4-methoxy-3-(3-methoxy propoxy) benzyl)-3-methyIbutan-l-ol useful intermediates in the synthesis of compound of formula- 1.

专利号:US-8563279-B2
优先权日:2007-12-24
标题 :Convergent synthesis of renin inhibitors and intermediates useful therein
发明人：DE LANGE BEN; CASTELIJNS ANNA MARIA CORNELIA FRANCISCA; DE VRIES JOHANNES GERARDUS; DE VRIES ANDREAS HENDRIKUS MARIA; BOOGERS JEROEN ANTONIUS FRANCISCUS; BROXTERMAN QUIRINUS BERNARDUS
权利人:DE LANGE BEN; CASTELIJNS ANNA MARIA CORNELIA FRANCISCA; DE VRIES JOHANNES GERARDUS; DE VRIES ANDREAS HENDRIKUS MARIA; BOOGERS JEROEN ANTONIUS FRANCISCUS; BROXTERMAN QUIRINUS BERNARDUS; DSM IP ASSETS BV
摘要:Described is a method for the preparation of renin inhibitors such as aliskiren, and intermediates useful therein. The method introduces a nitrogen-containing intermediate such as a lactone of formula (8). with R 4 being a branched C 3 — 6 alkyl. In the preparation of the lactone, or related intermediates, a desired stereochemical configuration can be controlled by starting from a chiral aldehyde satisfying formula (10).

专利号:WO-2009080773-A1
优先权日:2007-12-24
标题:Convergent synthesis of renin inhibitors and intermediates useful therein

专利号:US-7153675-B2
优先权日:2001-05-15
标 题 :Process for the preparation of substituted carboxylic esters
发明人：HEROLD PETER; STUTZ STEFAN
权利人:SPEEDEL PHARMA AG
摘要:A process for the preparation of 2(S)-alkyl-5-halogenpent-4-ene carboxylic esters by enzymatic hydrolysis, comprising the steps: a) enzymatic hydrolysis of racemic 2-alkyl-5-halogenpent-4-ene carboxylic esters in aqueous and alkaline medium in the presence of an esterase; b) isolation of 2(S)alkyl-5-halogenpent-4-ene carboxylic esters by extraction with an organic solvent; c) isolation of 2(R)-alkyl-5-halogenpent-4-ene carboxylic acids from the aqueous-alkaline medium; d) Esterification of 2(R)-alkyl-5-halogenpent-4-ene carboxylic acids, e) subsequent racemization to form 2-alkyl-5-halogenpent-4-ene carboxylic esters; and f) return of the racemate obtained in step e) to step a), if necessary together with fresh racemic 2-alkyl-5-halogenpent-4-ene carboxylic esters. The process permits the undesired R-stereoisomers to be converted into the desired 2(S)-alkyl-5-halogenpent-4-ene carboxylic esters to avoid waste product from the synthesis.

专利号:WO-2008006394-A8
优先权日:2006-07-14
标题 :Process for the preparation of optically active (4e)-5- halo-2-alkylpent-4-enoic acids and their ester derivatives
发明人：STIVANELLO MARIANO; GRANDINI CRISTIANO; GRENDELE ENNIO; FALCHI ALESSANDRO
权利人:ITALIANA SINT SPA; STIVANELLO MARIANO; GRANDINI CRISTIANO; GRENDELE ENNIO; FALCHI ALESSANDRO
摘要:A process for the preparation of optically active (4E)-5-halo-2-alkylpent-4-enoic acids and their ester derivatives by a stereoselective synthesis which employs camphorsultam as chiral auxiliary is disclosed; in particular methyl (2S, 4E)-5-chloro-2-isopropylpent-4-enoate is prepared, which is a key intermediate in the manufacturing of the new anti-hypertension drug Aliskiren. Furthermore novel N-(5-halo-2-alkylpent-4-enoyl) camphorsultams are provided. A process for the hydrolysis of substituted N-acylcamphorsultams with strong acids is also provided.

专利号:US-2013310577-A1
优先权日:2007-12-24
标题:Convergent synthesis of renin inhibitors and intermediates useful therein