CAS: 35231-44-8; 4-(Bromomethyl)-7-Methoxy-2H-Chromen-2-One

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CAS号2555-28-4 7-甲氧基-4-甲基香豆素 | CAS号150-19-6 3-甲氧基苯酚 | CAS号13176-46-0 4-溴乙酰乙酸乙酯 | CAS号108-46-3 间苯二酚 | CAS号161798-25-0 4-(bromomethyl)... | CAS号77-78-1 硫酸二甲酯 | CAS号108154-52-5 7-methoxy-4-(5-... | CAS号108154-54-7 4-(5-chloro-1-b... | CAS号239136-56-2 4-(aminomethyl)... | CAS号69716-05-8 2-(6-甲氧基-1-苯并呋喃... | CAS号72433-26-2 4-(羟甲基)-7-甲氧基-2... | CAS号75671-18-0 4-ethenyl-7-met... | CAS号60951-30-6 (7-methoxy-2-ox...

📜7-甲氧基-4-甲基香豆素置于n-溴代丁二酰亚胺(Nbs),过氧化苯甲酰体系中,用 四氯化碳 作为反应溶剂,化学反应 8.0H,以73%的收率获得产物4-溴甲基-7-甲氧基香豆素
参考文献:Design,Synthesis And Anticancer Activities Of Stilbene-Coumarin Hybrid Compounds: Identification Of Novel Proapoptotic Agents
标题:Design,Synthesis And Anticancer Activities Of Stilbene-Coumarin Hybrid Compounds: Identification Of Novel Proapoptotic Agents
摘要:The Naturally occurring Coumarins And Resveratrol,Attract Great Attention Due To Their Wide Range Of Biological Properties,Including Anticancer,Antileukemic,Antibacterial And Anti-Inflammatory Activities; Moreover,Their Cancer Chemopreventive Property Have Been Recently Emphasized. A Novel Class Of Hybrid Compounds,Obtained By Introducing A Substituted Trans-Vinylbenzene Moiety On A Coumarin Backbone,Was Synthesized And Evaluated For The Antitumor Profile. A Number Of Derivatives Showed A Good Antiproliferative Activity,In Some Cases Higher To That Of The Reference Compound Resveratrol. The Most Promising Compounds In This Series Were 14 And 17,Endowed With Excellent Antiproliferative And Proapoptotic Activities. The Present Study Suggests That The 7-Methoxycoumarin Nucleus,Together With The 3,5-Disubstitution Pattern Of The Trans-Vinylbenzene Moiety,Are Likely Promising Structural Features To Obtain Excellent Antitumor Compounds Endowed With A Apoptosis-Inducing Capability. (C) 2010 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmc.2010.03.069

专利信息

专利号:US-5247099-A
优先权日:1989-08-17
标题:Process for synthesis of 7-hydroxy coumarins having substitutions in the 4-position
发明人：CELEBUSKI JOSEPH E
权利人:ABBOTT LAB
摘要:A process for synthesis of a compound of the formula: said process comprising the steps of (a) reacting 4-bromomethyl-7-methoxy coumarin with a malonic ester under conditions sufficient to achieve condensation of the ester to give the monoalkylated (2-bis(carbalkoxy)-2-R1-1-ethyl) derivative; (b) removing one of the carbalkoxy groups from the product of step (a); (c) demethylation of the product of step (b) to give the 7-hydroxycoumarin compound; and (d) chemically modifying the remaining ester to yield a desired R2.

专利号:US-2007191395-A1
优先权日:2004-02-16
标题 :Heterocyclic compounds having antifungal activity
发明人：KAWAKAMI KATSUHIRO; KANAI KAZUO; FUJISAWA TETSUNORI; MORITA CHIKANORI; SUZUKI TAKASHI
权利人:KAWAKAMI KATSUHIRO; KANAI KAZUO; FUJISAWA TETSUNORI; MORITA CHIKANORI; SUZUKI TAKASHI
摘要:A compound which can specifically or selectively expresses an antifungal activity with a broad spectrum, based on the functional mechanism of 1,6-β-glucan synthesis inhibition, is provided, and an antifungal agent which comprises such a compound, a salt thereof or a solvate thereof is provided. A compound represented by the following formula (I), a salt thereof or a solvate thereof.