CAS: 35205-54-0; 1-Phenoxypropan-2-Amine

上下游产品

phenoxyacetone oxime 3-phenoxy-2-propanone formamide 1-phenoxy-2-propanol N,N-dimethyl-1-phenoxypropan-2-amine S-(+)-1-phenoxy-2-propanamine R-(-)-1-phenoxy-2-propanamine 7,8-dihydro-5-methyl-8-(1-methyl-2-phenoxyethyl)6H-pyrrolo[3,2-e][1,2,4]triazolo[1,5-a]pyrimidine

📜苯氧基丙酮置于甲酸铵,Sodium Cyanoborohydride体系中,用 甲醇 用作溶剂,化学反应 3.5H,以80%的收率获得(2R)-1-苯氧基丙-2-胺
参考文献:邻二胺作为转氨酶催化的酮不对称胺化中的智能共底物
标题:邻二胺作为转氨酶催化的酮不对称胺化中的智能共底物
摘要:转氨酶 (Ta) 最近已被确定为前手性酮不对称还原胺化的催化剂.根据酮底物和胺供体(共底物),平衡常数可能会限制高转化率;因此,需要克服这种限制的方法.通过自发的分子内反应从反应平衡中去除副产物为这个问题提供了成功的解决方案.因此,这些胺供体被命名为"智能共底物".在这里,我们比较了各种双功能胺供体,包括作为潜在结构共底物基序的连二胺.在 Ta 催化的 1,2-二胺脱氨基作用后,所得 α-氨基酮的自发二聚化和氧化得到杂芳族吡嗪.
Doi:10.1002/ejoc.201700253

专利信息

专利号:US-5300437-A
优先权日:1989-06-22
标 题 :Enantiomeric enrichment and stereoselective synthesis of chiral amines
发明人：STIRLING DAVID I; MATCHAM GEORGE W; ZEITLIN ANDREW L
权利人:CELGENE CORP
摘要:Amines in which the amino group is on a secondary carbon atom which is chirally substituted can be enantiomerically enriched by the action of an omega-amino acid transaminase which has the property of preferentially converting one of the two chiral forms to a ketone. The process also can be used to stereoselectively synthesize one chiral form from ketones substantially to the exclusion of the other.

专利号:US-10023886-B2
优先权日:2010-07-14
标题 :(R)-selective amination
发明人：SCHURMANN MARTIN; PEETERS WIJNAND PETER HELENA; SMEETS NATASCHA HUBERTINA JOHANNES; SCHWAB HELMUT; STEINER KERSTIN; LYPETSKA KATERYNA MYKOLAYIVNA; STROHMEIER GERNOT
权利人:DPX HOLDINGS BV; PATHEON HOLDINGS I B V
摘要:The present invention relates to a method for the enzymatic synthesis of enantiomerically enriched (R)-amines of general formula [1][c] n nfrom the corresponding ketones of the general formula [1][a]n n nby using novel transaminases.n n These novel transaminases are selected from two different groups: either from a group of some 20 proteins with sequences as specified herein, or from a group of proteins having transaminase activity and isolated from a microorganism selected from the group of organisms consisting of Rahnella aquatilis, Ochrobactrum anthropi, Ochrobactrum tritici, Sinorhizobium morelense, Curtobacterium pusiffium, Paecilomyces lilacinus, Microbacterium ginsengisoli, Microbacterium trichothecenolyticum, Pseudomonas citronellolis, Yersinia kristensenii, Achromobacter spanius, Achromobacter insolitus, Mycobacterium fortuitum, Mycobacterium frederiksbergense, Mycobacterium sacrum, Mycobacterium fluoranthenivorans, Burkhoideria sp., Burkhoideria tropica, Cosmospora episphaeria , and Fusarium oxysporum.

专利号:CN-110628739-B
优先权日:2019-08-14
标 题:Amine dehydrogenase mutant and application thereof in synthesis of chiral amine and amino alcohol

专利号:CN-110628739-A
优先权日:2019-08-14
标 题 :Amine dehydrogenase mutant and application thereof in synthesis of chiral amine and amino alcohol

专利号:US-10793848-B2
优先权日:2014-01-31
标题 :Immobilized proteins and use thereof
发明人：CASSIMJEE KARIM ENGELMARK; BÄCKVALL JAN-ERLING
权利人:ENGINZYME AB
摘要:The invention relates to an immobilized protein material comprising a protein that is immobilized on a glass material or organic polymer through affinity tag binding. The glass material may be a porous glass material such as (hybrid) controlled porosity glass. The invention also relates to the use of an immobilized enzyme material as a heterogeneous biocatalyst in chemical synthesis. The invention further relates to a method for the immobilization of affinity tagged proteins on a glass material or organic polymer, and to a method for the purification and isolation of affinity tagged proteins by the immobilization of such proteins on a glass material or organic polymer.

专利号:US-6613942-B1
优先权日:1997-07-01
标题 :Glucagon antagonists/inverse agonists
发明人：LING ANTHONY; GREGOR VLAD; GONZALEZ JAVIER; HONG YUFENG; KIEL DAN; KUKI ATSUO; SHI SHENGHUA; NAERUM LARS; MADSEN PETER; SAMS CHRISTIAN; LAU JESPER; PLEWE MICHAEL BRUNO; FENG JUN; TENG MIN; JOHNSON MICHAEL DAVID; TESTON KIMBERLY ANN; SIDELMANN ULLA GROVE; KNUDSEN LOTTE BJERRE
权利人:NOVO NORDISK AS
摘要:Non-peptide compounds comprising a central hydrazide motif and methods for the synthesis thereof are disclosed. The compounds act to antagonize the action of the glucagon peptide hormone.