CAS: 2566-89-4; (5Z,8Z,11Z,14Z)-Methyl Icosa-5,8,11,14-Tetraenoate

该化合物是源自芳烃酸的一种酯,一种多元饱和脂肪酸,在细胞信号和炎症中起着关键作用;其特点是由20个碳原子和4个双键组成的长碳氢化合物链,有助于其流动性和回活性.作为一个甲基酯,它有一个与芳烃酸碳酸碳盒酸功能组相连的甲基组,提高了其在有机溶剂中的溶解性.甲基芳烃酸经常用于生物化学研究,研究脂肪代谢,信号路径和蛋白类合成,这些物质在炎症反应中起着重要的媒介作用.其特性包括:在室温中无色到黄色液体,由于不饱和性,熔点相对较低.此外,它对于氧化具有敏感性,会影响其稳定性和再活性.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

diazomethane c,7c,10c,13c-tetraene1-chloro-nonadeca-4c,7c,10c,13c-tetraene carbon dioxide all cis 5,8,11,14-eicosatetraenoic acidmethyl arachidate arachidonyl alcohol *,6S*,8Z,11Z,14Z)-5,6-epoxyeicosa-8,11,14-trienoatemethyl (5R*,6S*,8Z,11Z,14Z)-5,6-epoxyeicosa-8,11,14-trienoate methyl arachidonate 8,9-epoxide

合成工艺路线路线简述

  • 合成目标产物 Methyl Arachidonate 主要起始原料 Arachidonic Acid
  • (文献来源)合成步骤主要原料 Arachidonic Acid
📜花生四烯酸 以 氯仿 用作溶剂,化学反应 5.0H,反应生成花生四烯酸甲酯
参考文献:1,1'-Oxalyldiimidazole,A New Reagent For Activation Of Carboxylic Acid
标题:1,1'-Oxalyldiimidazole,A New Reagent For Activation Of Carboxylic Acid
摘要:羧酸及其盐通过标题试剂转变为1-酰基咪唑.这一反应被应用于脂肪酸的酯化过程.
Doi:10.1246/cl.1983.1819

海关参考信息

专利信息


专利号:US-8124838-B2
优先权日:1998-12-07
标题 :Desaturases and methods of using them for synthesis of polyunsaturated fatty acids
发明人：BROWSE JOHN A; WALLIS JAMES G; WATTS JENNIFER L
权利人:BROWSE JOHN A; WALLIS JAMES G; WATTS JENNIFER L; UNIV WASHINGTON STATE RES FDN
摘要:The amino acid and nucleic acid sequences of a Δ 5 -desaturase enzyme and a Δ 8 -desaturase enzyme are disclosed. The nucleic acid sequences can be used to design recombinant DNA constructs and vectors. These vectors can then be used to transform various organisms, including for example, plants and yeast. The transformed organisms will then produce polyunsaturated fatty acids. The amino acid sequences are useful for generating enzyme-specific antibodies that are useful for identifying the desaturases.

专利号:US-9695450-B2
优先权日:1998-12-07
标题:Desaturases and methods of using them for synthesis of polyunsaturated fatty acids
发明人：BROWSE JOHN A; WALLIS JAMES G; WATTS JENNIFER L
权利人:WASHINGTON STATE UNIV RES FOUND; UNIV WASHINGTON STATE
摘要:The amino acid and nucleic acid sequences of a Δ 5 -desaturase enzyme and a Δ 8 -desaturase enzyme are disclosed. The nucleic acid sequences can be used to design recombinant DNA constructs and vectors. These vectors can then be used to transform various organisms, including for example, plants and yeast. The transformed organisms will then produce polyunsaturated fatty acids. The amino acid sequences are useful for generating enzyme-specific antibodies that are useful for identifying the desaturases.

专利号:EP-1147174-B1
优先权日:1998-12-07
标题:Desaturases and methods of using them for synthesis of polyunsaturated fatty acids
发明人：BROWSE JOHN A; WALLIS JAMES G; WATTS JENNIFER L
权利人:UNIV WASHINGTON
摘要:The amino acid and nucleic acid sequences of a DELTA <5>-desaturase enzyme and a DELTA <8>-desaturase enzyme are disclosed. The nucleic acid sequences can be used to design recombinant DNA constructs and vectors. These vectors can then be used to transform various organisms, including for example, plants and yeast. The transformed organisms will then produce polyunsaturated fatty acids. The amino acid sequences are useful for generating enzyme-specific antibodies that are useful for identifying the desaturases.

专利号:WO-2008044544-A1
优先权日:2006-10-04
标题 :Fine particle of hydroxide and/or oxide and process for producing the same
发明人：HORIGUCHI SHINICHI; ARIZONO JYUNICHI; OOSHIMA YASUHIRO
权利人:NISSHIN SPINNING; HORIGUCHI SHINICHI; ARIZONO JYUNICHI; OOSHIMA YASUHIRO
摘要:Fine particles of a hydroxide and/or oxide which are produced by electrodialysis; and a process for producing the fine particles. A conductive liquid which is a poor solvent for the hydroxide and/or oxide to be generated in a synthesis chamber is used as a synthesis-chamber liquid. The synthesis chamber is used in combination with a desalting chamber separated from the synthesis chamber by a cation-exchange membrane, the desalting chamber being filled with an aqueous electrolyte solution containing metal ions as a raw material for the hydroxide and/or oxide. A voltage not lower than the theoretical water electrolysis voltage is applied to the chambers. The fine hydroxide and/or oxide particles, which are produced through electrodialysis, are reduced in equipment cost and production cost.

专利号:US-2017283839-A1
优先权日:1998-12-07
标题:Desaturases and methods of using them for synthesis of polyunsaturated fatty acids

专利号:US-2006090221-A1
优先权日:1998-12-07
标 题:Desaturases and methods of using them for synthesis of polyunsaturated fatty acids

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合成参考文献


参考文献:10.1007/s11745-001-0781-x
摘要:Lin J, Fay LB, Welti DH, Blank I. Quantification of key odorants formed by autoxidation of arachidonic acid using isotope dilution assay. Lipids. 2001 Jul;36(7):749–56. doi: 10.1007/s11745-001-0781-x.
参考文献:10.1038/s41467-021-24482-1
摘要:Wu P, Chen D, Ding W, Wu P, Hou H, Bai Y, Zhou Y, Li K, Xiang S, Liu P, Ju J, Guo E, Liu J, Yang B, Fan J, He L, Sun Z, Feng L, Wang J, Wu T, Wang H, Cheng J, Xing H, Meng Y, Li Y, Zhang Y, Luo H, Xie G, Lan X, Tao Y, Li J, Yuan H, Huang K, Sun W, Qian X, Li Z, Huang M, Ding P, Wang H, Qiu J, Wang F, Wang S, Zhu J, Ding X, Chai C, Liang L, Wang X, Luo L, Sun Y, Yang Y, Zhuang Z, Li T, Tian L, Zhang S, Zhu L, Chang A, Chen L, Wu Y, Ma X, Chen F, Ren Y, Xu X, Liu S, Wang J, Yang H, Wang L, Sun C, Ma D, Jin X, Chen G. The trans-omics landscape of COVID-19. Nature Communications. 2021 Jul 27;12(1):4543. doi: 10.1038/s41467-021-24482-1.
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