CAS: 23465-76-1; 1-[2-(Diethylamino)Ethyl]-3-[(4-Methoxyphenyl)Methyl]Quinoxalin-2-One

上下游产品

3-(4-Methoxybenzyl)Quinoxalin-2-One 23465-75-0
4-(2-Chloroethyl)-2-Cyano-3-Oxo-3,4-Dihydroquinoxaline 1-Oxide 1610961-20-0

📜4-(2-Chloroethyl)-2-Cyano-3-Oxo-3,4-Dihydroquinoxaline 1-Oxide置于sodium Dithionite,叔丁基二甲基氯硅烷,Sodium Iodide体系中,用 四氢呋喃,二氯甲烷,水,丙酮,乙腈 用作溶剂,化学反应 51.0H,反应生成卡罗维林
参考文献:A Diversity-Oriented Synthesis Of Caroverine Derivatives Via Tempo-Promoted Aerobic Oxidative Cn Bond Formation
标题:A Diversity-Oriented Synthesis Of Caroverine Derivatives Via Tempo-Promoted Aerobic Oxidative Cn Bond Formation
摘要:A Concise Method Has Been Developed For The Synthesis Of Caroverine And Its Derivatives. The Quinoxalinone Scaffold Of These Compounds Was Constructed Via The Tandem Nitrosation/aerobic Oxidative C N Bond Formation Reaction Of N-(2-Chloroethyl)-2-Cyano-N-Phenylacetamide,Followed By Sequential Grignard,Finkelstein And Nucleophilic Substitutions Reactions To Give Several Different Derivatives. Herein,We Describe The Development Of This Strategy In Terms Of The Optimization Of Each Step As Well As The Effect Of Different Additives On The Individual Reactions. (C) 2014 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Tetlet.2014.03.061

专利信息

专利号:US-2012177593-A1
优先权日:2009-07-20
标 题 :Synthesis of dendrimer conjugates
发明人：BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH
权利人:BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH; UNIV MICHIGAN
摘要:The present invention relates to novel methods of synthesis of therapeutic and diagnostic dendrimers. In particular, the present invention is directed to novel dendrimer conjugates, novel methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer, inflammatory disease) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer conjugates of the present invention may further comprise at least two different components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. Furthermore, the novel synthesis methods of certain embodiments of the present invention provide significant advantages with regard to total reaction time and simplicity.

专利号:US-2006009642-A1
优先权日:2001-10-12
标题 :Methods for the synthesis of substituted purines
发明人：DING SHENG; DING QIANG; GRAY NATHANAEL S; SCHULTZ PETER G
权利人:IRM LLC
摘要:The invention provides general methods for preparing 2,9-, 2,6,9-, O 6 -aryl- and O 6 -alkyl-substituted purines in a combinatorial and traceless fashion. The methods involve, in some embodiments, Mitsunobu alkylation of 2-fluoro-6-phenylsulfenylpurine at N9 with alcohols in solution, followed by C2-capture of the purine core with a resin-bound amine and subsequent oxidation and displacement of the C6 sulfonyl group with amines and anilines.

专利号:US-6949644-B2
优先权日:2001-10-12
标题 :Methods for the synthesis of substituted purines
发明人：DING SHENG; DING QIANG; GRAY NATHANAEL S; SCHULTZ PETER G
权利人:SCRIPPS RESEARCH INST
摘要:The invention provides general methods for preparing 2,9-, 2,6,9-, O 6 -aryl- and O 6 -alkyl-substituted purines in a combinatorial and traceless fashion. The methods involve, in some embodiments, Mitsunobu alkylation of 2-fluoro-6-phenylsulfenylpurine at N9 with alcohols in solution, followed by C2-capture of the purine core with a resin-bound amine and subsequent oxidation and displacement of the C6 sulfonyl group with amines and anilines. In one aspect, the present invention provides a method of preparing a 2,6,9-substituded purine compounds of Formula I: n n nthe method comprising:n a) oxidizing a resin-bound compound of Formula II: n n to provide a resin-bound compound of Formula III: n n b) reacting the compound of Formula III with an amine of Formula IVn nNR 3 R 4   IV,n nto provide a resin-bound compound of Formula V n n c) cleaving the resin-bound compound of Formula V from the resin to provide the substituted purine compounds of Formula I.

专利号:US-9220714-B2
优先权日:2006-03-16
标 题 :Nitrofuran compounds for the treatment of cancer and angiogenesis
发明人：SAULNIER SHOLLER GISELLE L; SWAMY NARASIMHA; KALKUNTE STAYAN; SINGH RAKESH K; BRARD LAURENT; KIM KYU KWANG
权利人:WOMEN AND INFANTS HOSPITAL OF RHODE ISLAND; UNIV BROWN; WOMEN AND INFANTS HOSPITAL RHODE ISLAND
摘要:The invention is directed to the synthesis and use of nitrofuran compounds, especially Nifurtimox, as medicaments to treat cancer, especially neuroblastoma, and to inhibit angiogenesis. The invention also provides compositions, unit dosage forms, and kits comprising the compounds.

专利号:US-2015352230-A1
优先权日:2013-01-11
标 题:Synthesis and isolation of dendrimer based imaging systems
发明人：MULLEN DOUGLAS GURNETT; BAKER JR JAMES R; BANASZAK HOLL MARK M; HUANG BAOHUA; DOUGHERTY CASEY; BALL JACK
权利人:UNIV MICHIGAN
摘要:The present invention relates to novel methods of synthesis and isolation of antibodies conjugated with modular dendrimer nanoparticles. In particular, the present invention is directed to antibodies conjugated with novel modular dendrimer nanoparticles having precise numbers of imaging agents, methods of synthesizing the same, compositions comprising such antibodies conjugated with such modular dendrimer nanoparticles, as well as systems and methods utilizing the conjugates (e.g., in imaging settings) (e.g., in diagnostic and/or therapeutic settings) (e.g., for the delivery of therapeutics, imaging, and/or targeting agents).

专利号:US-2012232225-A1
优先权日:2009-08-26
标 题:Synthesis and isolation of dendrimer systems
发明人：BAKER JR JAMES R; BANASZAK HOLL MARK M; MULLEN DOUGLAS GURNETT; ORR BRADFORD G; DESAI ANKUR; SANDER LEONARD M; WADDELL JACK NEEL
权利人:BAKER JR JAMES R; BANASZAK HOLL MARK M; MULLEN DOUGLAS GURNETT; ORR BRADFORD G; DESAI ANKUR; SANDER LEONARD M; WADDELL JACK NEEL; UNIV MICHIGAN
摘要:The present invention relates to novel methods of synthesis and isolation of dendrimer systems. In particular, the present invention is directed to novel dendrimer conjugates with defined and limited numbers of ligand conjugates and high levels of structural uniformity, methods of synthesizing the same, compositions comprising the conjugates, as well systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)).