CAS: 22818-40-2; H-D-Phg(4-Oh)-Oh

相似化合物

32462-30-9 69651-48-5 178119-93-2

上下游产品

(S)-2-Amino-3-{[(R)-carboxy-(4-hydroxy-phenyl)-methyl]-amino}-propionic acid (R)-ethyl 2-amino-2-(4-hydroxyphenyl)acetate 5-[2-(methylthio)ethyl]imidazolidine-2,4-dione 5-(4-hydroxy-phenyl)-imidazolidine-2,4-dioneD-2-p-hydroxyphenylglycine methyl ester methyl 4-methoxyphenyl-D-phenylglycinate

头孢羟氨苄置于水体系中,化学反应生成D(-)-对羟基苯甘氨酸
参考文献:磁性固定化青霉素g酰基转移酶在[bmim] [ntf2]-磷酸酯助溶剂中高效合成头孢氨苄
标题:磁性固定化青霉素g酰基转移酶在[bmim] [ntf2]-磷酸酯助溶剂中高效合成头孢氨苄
摘要:头孢氨苄首次由7-氨基-3-去乙酰氧基头孢菌酸和d-羟苯基甘氨酸甲酯在[bmim] [ntf 2 ]-磷酸酯助溶剂中合成,能够使用固定在其上的青霉素g酰基转移酶(pga)溶解底物.微米级磁性聚合物微球,具有2,083 U / G的高活性.在相同的最佳反应条件下,使用游离pga仅获得了1.12的高合成/水解(s / H)比和79.0%的收率,其中只有0.19的s / H比和20.0%的收率获得了.在[bmim] [ntf 2磁性固定的pga产生的]-磷酸酯助溶剂,表明头孢氨苄的酶法合成中有两个非常关键且必不可少的设计,即有效的支持和pga合适的溶剂体系.显然,磁性固定的pga和离子液体溶剂在生物催化中具有很大的潜力.
Doi:10.1002/jccs.201900272

专利信息

专利号:US-2004006137-A1
优先权日:2002-06-28
标题:Asymmetric synthesis of amino-pyrrolidinones and a crystalline, free-base amino-pyrrolidinone
发明人：WALTERMIRE ROBERT E; CAMPAGNA SILVIO; SAVAGE SCOTT A; BORDAWEKAR SHAILENDRA; MADUSKUIE THOMAS P; DESIKAN SRIDHAR; ANDERSON STEPHEN R
摘要:A novel process for the asymmetric synthesis of an amino-pyrrolidinone of the type shown below is described. n n n These compounds are useful as intermediates for MMP and TACE inhibitors. n Crystalline, free-base form of Compound J ((2R)-2-((3R)-3-amino-3-{-[(2-methyl-4-quinolinyl)methoxy]phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide): n n n which is useful as a TACE inhibitor, pharmaceutical compositions comprising the same, and methods of using the same for treating inflammatory diseases are also described.

专利号:US-2018222848-A1
优先权日:2015-08-04
标 题:Salt of Dihydrophenylglycine Methyl Ester
发明人：VAN DER DOES THOMAS; MOODY HAROLD MONRO; LI WEIDONG
权利人:DSM SINOCHEM PHARM NL BV
摘要:The present invention relates to the hemi sulfuric acid salt of methyl (R)-2-amino-2-(cyclohexa-1,4-dien-1-yl)acetate, also trivially referred to as the hemi sulfuric acid salt of D-dihydrophenylglycine methyl ester, to a method for the preparation of said salt and to the use of said salt in the enzymatic synthesis of antibiotics.

专利号:US-8703996-B2
优先权日:2010-03-09
标题:Short synthesis of tolterodin, intermediates and metabolites
发明人：STERK DAMJAN
权利人:STERK DAMJAN; LEK PHARMACEUTICALS
摘要:A process is described for the preparation of intermediates which can be used for preparation of agents for urinary incontinence therapy, specifically to 2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenol and its prodrugs.

专利号:US-2017298406-A1
优先权日:2014-09-22
标 题 :Salt of phenylglycine methyl ester
发明人：VAN DER DOES THOMAS
权利人:DSM SINOCHEM PHARM NL BV
摘要:The present invention relates to the hemi sulfuric acid salt of D-phenylglycine methyl ester, to a method for the preparation of said salt and to the use of said salt in the enzymatic synthesis of antibiotics and of D-phenylglycine methyl ester free base.

专利号:US-8044173-B2
优先权日:2005-09-13
标 题 :Asymmetric synthesis of peptides
发明人：HARWOOD LAURENCE M; YAN RAN
权利人:UNIV READING
摘要:A process comprising substitution of an acceptor molecule comprising a group —XC(O)— wherein X is O, S, or NR 8 , where R 8 is C 1-6 alkyl, C 6-12 aryl or hydrogen, with a nucleophile, wherein the acceptor molecule is cyclised such that said nucleophilic substitution at —XC(O)— occurs without racemisation, is provided. This process has particular application for the production of a peptide by extension from the activated carboxy-terminus of an acyl amino acid residue without epimerisation.

专利号:US-8039662-B2
优先权日:2007-03-09
标 题:Process for the preparation of amino acid methyl esters
发明人：MOODY HAROLD MONRO
权利人:DSM IP ASSETS BV
摘要:The present invention describes a process for the synthesis of an amino acid methyl ester comprising the following steps: (a) refluxing a reaction mixture comprising a free amino acid, methanol and a strong acid; (b) concentrating the mixture; (c) adding methanol; (d) repeating steps a-c one or more times.