CAS: 2215-21-6; 2-Hydroxy-3,5-Diisopropylbenzoic Acid

该化合物是一种有机化合物,其特征是其硅酸脊柱,在3和5个位置上以异丙基组替代,这种结构有助于其独特的物理和化学特性,该化合物一般是白色的脱白晶状固体,在水中相对不溶解,但在乙醇和丙酮等有机溶剂中可能溶解,但因碳oxylic酸功能组的存在而表现出酸性,允许其参与各种化学反应,包括酯化和恐吓. 3,5-二异丙基硅酸也可能展示生物活动,使其对药物研究感兴趣.该化合物的分子结构影响其再活动性和潜在应用,包括作为有机合成的中间体或作为潜在的治疗剂使用.在处理和接触准则方面,应参考安全数据,如任何化学物质一样,用于处理和接触准则.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

isopropyl alcohol salicylic acid 2,4-diisopropylphenol 2-hydroxy-3,5-diisopropyl-benzoic acid methyl ester 3,5-di-iso-propylacetylsalicylic acid 4-carbomethoxyphenyl 3,5-diisopropylsalicylate

合成工艺路线路线简述

  • 合成目标产物 3,5-Diisopropylsalicylic Acid 主要起始原料 Salicylic Acid
  • (文献来源)合成步骤主要原料 Salicylic Acid
📜水杨酸置于异丙醇,硫酸体系中,化学反应 6.0H,以to Give 2-Hydroxy-3,5-Diisopropyl Benzoic Acid (M.P. 113°-116oc) In 40% Yield的收率获得3,5-二异丙基邻羟基苯甲酸
参考文献:Hydrazide Salts
标题:Hydrazide Salts
摘要:具有通式##spc1##的化合物,其中r.Sup.1,R.Sup.2,R.Sup.3和r.Sup.4可以相同也可以不同,代表氢,具有1至20个碳原子的直链或支链烷基基团,具有7至20个碳原子的芳基烷基基团,可以被一个或多个具有1至4个碳原子的烷基基团取代,或者可以是以下类型之一:##spc2## 其中r.Sup.5和r.Sup.6分别是氢原子或甲基基团,每个r代表r.Sup.1,R.Sup.2,R.Sup.3和r.Sup.4的其他基团,具有2至20个碳原子的烯基基团;具有5至12个碳原子的环烷基基团,可以被一个或多个具有1至4个碳原子的烷基基团取代;具有6至10个碳原子的芳基基团;具有7至12个碳原子的烷基芳基基团;具有2或3个碳原子的烷基基团和环己烯基环可能包含一个甲基基团作为取代基的环己基烷基基团;具有2或3个碳原子的烯基环己基基团,其中烯基基团具有2或3个碳原子,环己基环也可能包含一个甲基基团作为取代基;或者是一个-Or.Sup.7基团,其中r.Sup.7代表具有1至20个碳原子的烷基基团,具有5至12个碳原子的环烷基基团,可以选择一个或多个具有1至4个碳原子的烷基基团取代,具有6至10个碳原子的芳基基团,或具有3至20个碳原子的烯基基团;或者任意两个相邻的基团r.Sup.1,R.Sup.2,R.Sup.3和r.Sup.4可以连接在一起形成一个芳基环,该芳基环可以被一个或多个具有1至20个碳原子的烷基基团取代;X代表阴离子;N是x的价,该化合物对于从水溶液中提取金属是有用的.

海关参考信息

专利信息


专利号:US-4970309-A
优先权日:1985-12-16
标题:Synthesis of thiolactones
发明人:KING PATRICK F
权利人:POLAROID CORP
摘要:This invention relates to a novel method of synthesizing di- and triarylmethane dye precursor compounds possessing a thiolactone ring-closing moiety, from the corresponding lactones.

专利号:US-2024228986-A1
优先权日:2021-05-14
标题 :Engineered cells, enzymes, and methods for producing cannabinoids
发明人:KAMBOURAKIS SPIROS; KEUL NICHOLAS DONALD; KOMOR RUSSELL SCOTT; URANO JUN; CAIAZZA NICKY CHRISTOPHER
权利人:CELLIBRE INC
摘要:Disclosed herein are novel CBGA and CBGVA synthases and methods for improvement of their overall activities for the synthesis of CBGA and CBGVA from their respective precursors, olivetolic acid (OA) or divarinic acid (DVA) and GPP. Also disclosed are fusion proteins to enhance synthesis of CBGA and CBGVA. The methods described herein also increase the titer and the purity of CBGA and CBGVA made by a cell by 1) decreasing the formation of byproducts FCBGA and FCBGVA that are synthesized from the respective prenylation of OA and DVA with FPP, and/or 2) increasing the intracellular availability of OA and DVA.

专利号:US-8273403-B2
优先权日:2002-05-10
标题 :Generation of surface coating diversity
发明人:BARDEN MICHAEL C; KAMBOURIS PETER A
权利人:BARDEN MICHAEL C; KAMBOURIS PETER A; BIO LAYER PTY LTD
摘要:This invention relates to a surface discovery system and high-throughput combinatorial synthesis methods for generating large numbers of diverse surface coatings on solid substrates. The system is built upon a synthon which comprises at least three elements: a chemical backbone coating on the solid substrate that comprises a copolymer (B) of at least one passive constituent (P) and at least one active constituent (A); a spacer unit (S) separating the backbone from a functional group; and a functional group (F). The methods comprise the following steps: 1) selecting a plurality of synthons so that each synthon has at least two points of diversity selected from P, A, S and F; 2) applying copolymer B onto a substrate; and 3) attaching a combination of S and F to constituent A of copolymer B. Steps 2) and 3) are performed such that different synthons are generated on localized regions of the substrate.

专利号:WO-2025007156-A2
优先权日:2023-06-30
标 题:Enzymes and methods for the synthesis of bakuchiol and derivatives

专利号:US-7196230-B2
优先权日:2002-03-11
标 题 :Phosoxophite ligands and use thereof in carbonylation processes
发明人:PENG WEI-JUN; BRYANT DAVID ROBERT
权利人:UNION CARBIDE CHEM PLASTIC
摘要:A novel organophosphorus composition and synthesis thereof, the composition being characterized by one phosphite moiety, one phosoxophite moiety, and a plurality of sterically bulky substituents. The novel composition finds utility as a ligand in Group VIII transition metal phosoxophite complex catalysts and complex catalyst precursors that are used in carbonylation processes, preferably, hydroformylation processes. Additionally, there is disclosed a novel method of preparing a phosphoromonochloridite composition that finds utility as a precursor to the novel phosoxophite composition.

专利号:US-9649292-B2
优先权日:2015-07-13
标 题:Method for treating prostate cancer and/or gastrointestinal cancer
发明人:AL-JAROUDI SAID; ALTAF MUHAMMAD; AL-SAADI ABDULAZIZ; ISAB ANVARHUSEIN ABDULKADIR
权利人:UNIV KING FAHD PET & MINERALS
摘要:Gold(III) complexes having mixed ligands as anticancer agents. The gold(III) complexes are coordinated to bidentate ligands having diamino functional groups: a diaminocyclohexane ligand and an ethylenediamine ligand. These complexes can exist in both cis- and trans-configurations. Also described are pharmaceutical compositions incorporating the gold(I) complexes, methods of synthesis, methods of treating cancer and methods of inhibiting cancer cell proliferation and inducing cancer cell apoptosis.

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献

[参考文献]: Eugene O Apostolov, Et Al. Deoxyribonuclease I Is Essential For Dna Fragmentation Induced By Gamma Radiation In Mice. Radiat Res. 2009 Oct;172(4):481-92.
[参考文献]: L F Charles, Et Al. Fabrication And Mechanical Properties Of Plla/pcl/ha Composites Via A Biomimetic, Dip Coating, And Hot Compression Procedure. J Mater Sci Mater Med. 2010 Jun;21(6):1845-54.
[参考文献]: M Roch-Arveiller, Et Al. Effects Of Some Non-Steroidal Anti-Inflammatory Drug Copper Complexes On Polymorphonuclear Leukocyte Oxidative Metabolism. Agents Actions. 1990 Aug;31(1-2):65-71.
[参考文献]: Michèle Lamoureux, Et Al. Fluorescence Labelling Of Dna By Carboxylic Polypyridyl-Ru Complexes Containing Bpy And Dip Ligands: A Study Revisited. J Fluoresc. 2010 May;20(3):631-43.
[参考文献]: V Brumas, Et Al. Copper(Ii) Interaction With 3,5-Diisopropylsalicylic Acid (Dips): New Insights On Its Role As A Potential *oh Inactivating Ligand. J Inorg Biochem. 2007 Apr;101(4):565-77.

合成参考文献


摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
参考文献:10.1007/bf02786261
摘要:Abdul-Ghani AS, Abu-Hijleh AL, Nahas N, Amin R. Hypoglycemic effect of copper(II) acetate imidazole complexes. Biol Trace Elem Res. 1996 Aug;54(2):143–51. doi: 10.1007/bf02786261.
摘要:Viossat B, Morgant G, Sorenson JR, Roch-Arveiller M, Daran JC, Greenaway FT, Nguyen Huy D. [Crystallochemistry of copper (II) and zinc (II) chelates by nonsteroidal antiinflammatory drugs]. Ann Pharm Fr. 2002 Mar;60(2):102–14.
参考文献:10.1038/174044b0
摘要:WALKER GW. A polarographic method for the determination of the gamma isomer of benzene hexachloride in cattle dips. Nature. 1954 Jul 03;174(4418):44–5. doi: 10.1038/174044b0.
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