CAS: 2210-63-1; 4-Butyl-1-Phenylpyrazolidine-3,5-Dione

📜丁基丙二酸二甲酯,苯肼置于sodium Ethanolate体系中,化学反应生成单苯基保泰松
参考文献:überneue 3,5-二氧杂吡唑烷
标题:überneue 3,5-二氧杂吡唑烷
摘要:Es Wurde Eine Reihe Von 3,5-Dioxo-Pyrazolidinen Hergestellt And Auf I Pharmakologischen Eigenschaften Untersucht.在4 Stellung蜂巢中死亡替代,在2 Stellung中由wirkung Viel Grundlegender Als Eine Solche代替.Bei Geeigneter替代der Stellung中的4-Stellungverstärkteine Phenylgruppe 1 Schon Vorhandene Pharmakologische Pharmaconlogische Wirkung Wesentlich.
Doi:10.1002/hlca.19530360112

专利信息

专利号:US-2004152905-A1
优先权日:2003-01-31
标题:Universal building blocks and support media for synthesis of oligonucleotides and their analogs
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and chemically modified oligonucleotide analogs, are provided. In addition, methods for functionalization of a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-2012177593-A1
优先权日:2009-07-20
标 题 :Synthesis of dendrimer conjugates
发明人：BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH
权利人:BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH; UNIV MICHIGAN
摘要:The present invention relates to novel methods of synthesis of therapeutic and diagnostic dendrimers. In particular, the present invention is directed to novel dendrimer conjugates, novel methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer, inflammatory disease) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer conjugates of the present invention may further comprise at least two different components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. Furthermore, the novel synthesis methods of certain embodiments of the present invention provide significant advantages with regard to total reaction time and simplicity.

专利号:US-8546532-B2
优先权日:2008-04-17
标题:Synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders
发明人：BONNIN DUSTAN; ZANELLI ERIC; MATHERS THOMAS
权利人:BONNIN DUSTAN; ZANELLI ERIC; MATHERS THOMAS; DECLION PHARMACEUTICALS INC
摘要:The instant invention comprises a process for the solid phase synthesis of directed epitope peptide mixtures useful in the treatment and diagnosis of protein conformational disorders, such process defined by a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use. The invention also pertains to the process of generating antibodies using the directed epitope peptide mixtures as the antigens, and antibodies generated by such process, useful in the treatment and diagnostics of the said protein conformational disorder.

专利号:US-9145368-B2
优先权日:2011-12-15
标 题 :Organocatalytic synthesis of chiral pyrazolidines and their analogues
发明人：KUMAR BOOPATHI SENTHIL; VENKATARAMASUBRAMANIAN VAITHIYANATHAN; SUDALAI ARUMUGAM
权利人:COUNCIL SCIENT IND RES
摘要:Disclosed herein is a highly enantio- (75 to 98% ee) and diastereoselective (99 to 100% de) synthesis of functionalized pyrazolidines via tandem a-amination-Corey Chaykovsky reaction of alpha unsubstituted aldehydes.

专利号:US-6538094-B2
优先权日:1998-12-21
标题:Process for synthesis of allophanate compounds and compositions including the product thereof
发明人：TAZZIA CHARLES L
权利人:BASF CORP
摘要:The invention provides a process for preparing an allophanate-containing compound in the presence of a metal catalyst and a tertiary amine. In a preferred process, the tertiary amine compound also has a hydroxyl group. The hydroxyl group can react with the isocyanate functionality. Also disclosed is a process in which an allophanate-containing compound is prepared with copper acetate monohydrate as a catalyst. The allophanate-containing compound is used as a curing agent in coating compositions, particularly electrocoat coating compositions. The coating compositions are used to coat articles.

专利号:US-9051302-B2
优先权日:2008-01-15
标 题 :Synthesis of resorcylic acid lactones useful as therapeutic agents
发明人：WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN
权利人:WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN; UNIV STRASBOURG
摘要:Disclosed are macrocyclic compounds of formulae I, I′, II, II′, III, III′, IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90.