CAS: 220641-87-2; N-Methyltetrahydro-2H-Pyran-4-Amine

化学文摘社编号为220641-87-2,可以精确地识别化学数据库,协助在各个领域的研究和应用,包括药物和有机合成.与许多氨一样,它也可能参与氢的结合,影响其物理特性以及与其他分子的相互作用.

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211814-15-2 392277-22-4 443344-23-8

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CAS号38041-19-9 4-氨基四氢吡喃 | CAS号50-00-0 甲醛 | CAS号29943-42-8 四氢吡喃酮 | CAS号25895-60-7 氰基硼氢钠 | CAS号593-51-1 一甲胺盐酸盐 | CAS号874888-66-1 4-[N-(tetrahydr... | CAS号229007-08-3 N-methyl-N-[(4-...

合成工艺路线路线简述

    📜四氢吡喃酮置于5%-Palladium/activated Carbon,氢气,Potassium Carbonate,三乙胺体系中,用 甲醇,N,N-二甲基甲酰胺 用作溶剂,60.0 °C,500.01 Kpa 条件下,反应 6.0H,反应生成N-甲基四氢-2H-吡喃-4-胺
    参考文献:Process Development Of 4-[n-Methyl-N-(Tetrahydropyran-4-yl)Aminomethyl]Aniline Dihydrochloride: A Key Intermediate For Tak-779,A Small-Molecule Nonpeptide Ccr5 Antagonist
    标题:Process Development Of 4-[n-Methyl-N-(Tetrahydropyran-4-yl)Aminomethyl]Aniline Dihydrochloride: A Key Intermediate For Tak-779,A Small-Molecule Nonpeptide Ccr5 Antagonist
    摘要:A New And Efficient Synthesis Of 4-[n-Methyl-N-(Tetrahydropyran-4-yl)Aminomethyl]Aniline Dihydrochloride,A Key Intermediate For The Ccr5 Antagonist Tak-779,Is Described. Reductive Alkylation Of Methylamine With Tetrahydro-4H-Pyran-4-One Followed By Alkylation Of N-Methyl-N-(Tetrahydropyran-4-yl)Amine With 4-Nitrobenzylbromide And Reduction Of N-(4-Nitrobenzyl)-N-(Tetrahydropyran-4-yl)Amine Results In A 78% Isolated Yield From The Starting Materials By A Scalable Method,Using Only Commercially Available Reagents.
    Doi:10.1021/op010052O

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    专利信息


    专利号:US-9458111-B2
    优先权日:2010-07-29
    标题:Process for the synthesis of substituted urea compounds
    发明人：LEARMONTH DAVID ALEXANDER; BROADBELT BRIAN; WAHNON JORGE BRUNO REIS
    权利人:LEARMONTH DAVID ALEXANDER; BROADBELT BRIAN; WAHNON JORGE BRUNO REIS; BIAL—PORTELA & CA S A
    摘要:A process for preparing a substitute urea of Formula (II) or Formula (I), or a pharmaceutically acceptable salt or ester thereof: n nthe process comprising the reaction of a carbamate of Formula (II′): Formula (I′):n n nwith a primary or secondary amine of the formula R1R2NH, wherein ring A, and R1, R2, R5, V, W, X, Y and Z are as defined herein.

    专利号:US-2022267331-A1
    优先权日:2019-06-05
    标题 :Dopamine-b-hydroxylase inhibitors
    发明人：KISS LASZLO; BELIAEV ALEXANDER; ROSSI TINO; PALMA NUNO; SOARES DA SILVA PATRÃ CIO; PINTO RUI; CARDONA FRANCISCO
    权利人:BIAL PORTELA & CA SA
    摘要:This invention relates to: (a) compounds of formula I (with R1 to R5 and A as defined herein) and pharmaceutically acceptable salts or solvates thereof that are useful as dopamine-β-hydroxylase inhibitors; (b) pharmaceutical compositions comprising such compounds, salts or solvates; (c) the use of such compounds, salts or solvates in therapy; (d) therapeutic methods of treatment using such compounds, salts or solvates; and (e) processes and intermediates useful for the synthesis of such compounds.

    专利号:US-2013123493-A1
    优先权日:2010-07-29
    标题 :Process for the synthesis of substituted urea compounds

    专利号:EP-2606035-B1
    优先权日:2010-07-29
    标题:Proces for the synthesis of substituted urea compounds

    专利号:CN-116355034-A
    优先权日:2021-12-28
    标 题 :Synthesis of AKBA Compounds and Their Application in Antineoplastic Drugs

    专利号:CN-116836130-B
    优先权日:2023-08-31
    标题:A kind of synthesis method of 3,4-dihydrobenzothiadiazine compounds

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    合成参考文献


    摘要:Scholz, U.; Dong, W.; Feng, J.; Shi, W., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 2, 70.
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