CAS: 19542-77-9; N-Acetyl-S-Benzyl-L-Cysteine

该化合物是一种化学化合物,属于甲卡普turic酸类,是甲卡普turic酸和各种电极的结合物,通过乙基氯和其他苯基衍生物的新陈代谢形成,通常存在于肝脏,在解毒过程中发挥作用;该化合物的特点是其甲卡普坦功能组,该组具有硫醇特性,使其具有反应性,并能够形成硫化物;该组通常在环境健康方面研究苯丙基酸,特别是作为接触苯基化合物的生物标志,这种物质可以存在于各种工业用途和消费品中;其分子结构包括一个与甲卡普酸混合物相连的苯基组,有助于生物液体中的溶性;该化合物一般被认为具有低挥发性,不被归类为持久性有机污染物;了解其特性对于评估与接触苯基物质相关的潜在健康风险至关重要.

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CAS号616-91-1 N-乙酰半胱氨酸 | CAS号100-39-0 溴化苄 | CAS号100-44-7 氯化苄 | CAS号3054-01-1 S-苄基-L-半胱氨酸 | CAS号108-24-7 乙酸酐 | CAS号463-51-4 乙烯酮 | CAS号5680-65-9 2R-amino-3-benz... | CAS号19519-04-1 (2R)-3-benzylsu... | CAS号90843-71-3 Propanoic acid,... | CAS号10061-65-1 (2R)-2-acetamid... | CAS号3054-01-1 S-苄基-L-半胱氨酸

合成工艺路线路线简述

    📜S-苄基-L-半胱氨酸 反应生成N-乙酰基卞基半胱氨酸
    参考文献:Stekol,Journal Of Biological Chemistry,1946,Vol. 164,P. 651,652
    标题:Stekol,Journal Of Biological Chemistry,1946,Vol. 164,P. 651,652

    海关参考信息

    专利信息


    专利号:US-2024400861-A1
    优先权日:2021-10-01
    标题 :Triazole- And/Or Triazolium-Based Polymers And Copolymers As Additives For Chemical Mechanical Planarization Slurries
    发明人:LARBIG GREGOR; KIRSCH PEER; HENGST MATTHIAS; SHI XIAOBO; STENDER MATTHIAS
    权利人:VERSUM MAT US LLC
    摘要:Synthesis of triazole- and/or triazolium-based polymers is disclosed. Chemical Mechanical Planarization (CMP) slurries comprise abrasives; activator; oxidizing agent; additive comprising triazole- and/or triazolium-based polymers; and water. The use of the synthesized triazole- and/or triazolium-based polymers in the CMP slurries reduces dishing and erosion in highly selective tungsten slurries.

    专利号:WO-2024073211-A1
    优先权日:2022-09-29
    标题:Guanidinium-based polyionic liquids and their use as additives for chemical mechanical planarization slurries
    发明人:LARBIG GREGOR; KIRSCH PEER; SHI XIAOBO
    权利人:VERSUM MAT US LLC
    摘要:Synthesis of guanidinium-based polymers is disclosed. Chemical Mechanical Planarization (CMP) slurries comprise abrasives; activator; oxidizing agent; additive comprising guanidinium-based polymers; and water. The use of the synthesized guanidinium-based polymers in the CMP slurries reduces dishing and erosion in highly selective tungsten slurries.

    专利号:US-2025215130-A1
    优先权日:2022-04-11
    标 题:Polycationic Polymer Or Copolymer Having Different Cation Types For Slurries In Chemical Mechanical Planarization
    发明人:LARBIG GREGOR; SHI XIAOBO
    权利人:MERCK PATENT GMBH; VERSUM MAT US LLC
    摘要:Synthesis of polycationic polymer or copolymer is disclosed. The polycationic polymer or copolymer are formed by at least one first cationic monomer and at least one second cationic monomer wherein the first cationic monomer and the second cationic monomer have different cationic groups; such as imidazolium group and non-imidazolium group. Chemical Mechanical Planarization (CMP) slurries comprise abrasives; activator; oxidizing agent; additive comprising polycationic polymer or copolymer; and water are also disclosed. The use of the synthesized polycationic polymer or copolymer in the CMP slurries reduces dishing and erosion in highly selective tungsten slurries.

    专利号:WO-2024073209-A1
    优先权日:2022-09-30
    标 题 :Modified water-soluble polysaccharides having different cation types for slurries in chemical mechanical planarization
    发明人:DAVIDI INBAL; LARBIG GREGOR; SHI XIAOBO; MA SANA
    权利人:VERSUM MAT US LLC
    摘要:Synthesis of cationic-modified water-soluble polysaccharide is disclosed. The cation is pendent to the polysaccharide backbone. Chemical Mechanical Planarization (CMP) slurries comprise abrasives; activator; oxidizing agent; additive comprising cationic-modified water-soluble polysaccharide; and water. The use of the synthesized cationic-modified water-soluble polysaccharide in the CMP slurries reduces dishing and erosion in highly selective tungsten slurries.

    专利号:WO-2024129383-A1
    优先权日:2022-12-13
    标 题 :Dicationic polymer and copolymer and their use for chemical mechanical planarization
    发明人:LARBIG GREGOR; MA SANA
    权利人:VERSUM MAT US LLC
    摘要:Synthesis of dicationic polymer or copolymer is disclosed. The dicationic polymer or copolymer are formed by at least one dicationic(or dual-cationic) monomer. Chemical Mechanical Planarization (CMP) slurries comprise abrasives; activator; oxidizing agent; additive comprising dicationic polymer or copolymer; and water. The use of the synthesized dicationic polymer or copolymer in the CMP slurries reduces dishing and erosion in highly selective tungsten slurries.

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    ✅ COA系统入驻 | 共享模式

    主要参考文献

    参考标题:Initial Intraorgan Formation Of Mercapturic Acid.
    作者:Kazumi Sano,Yoji Ikegami,Takashi Uesugi
    摘要:The Disposition Of S-Benzyl-Glutathione (Bsg) In Male Wistar Rats Was Evaluated By The Hplc Method To Examine Whether The Kidney And Liver Contributed Independently To The Biosynthesis Of S-Benzyl-N-Acetylcysteine (Bnac), A Mercapturic Acid (Chart 1). After Intravenous Injection, Bsg Was Rapidly Transported In Both The Kidney And The Liver At A Ratio Of About 7:3. Simultaneously, A Large Amount Of Bnac Was Found In Both The Kidney And The Liver. In The Kidney, S-Benzyl-Cysteine (Bcys) Reached A Maximum Concentration (Cmax) At 2 Min After Bsg Injection, Whereas Bnac Reached Cmax Within 3 To 5 Min. The Generation Of Bnac Was Also Observed In The Liver. While Renal Bnac Reached Cmax Within 3 To 5 Min, Hepatic Bnac Reached Cmax Around 5 Min After Bsg Injection. Moreover, The Elimination Half-Life Of The Bnac After Intravenous Injection Of The Bsg Was Equivalent To That Observed After Intravenous Injection Of The Bnac Itself. These Results Demonstrate That The Kidney Contributes To The Initial Intraorgan Generation Of Bnac And That This Mercapturic Acid Is Also Synthesized In The Liver And Preferentially Excreted Into Urine.

    合成参考文献


    参考文献:10.1093/jat/16.3.147
    摘要:Dinoff TM, Winter CK, Jones AD, New R. An Evaluation of Sample Preparation Techniques for the GC/MS Analysis of Urinary aercapturic Acid Conjugates. Journal of Analytical Toxicology. 1992 May 01;16(3):147–51. doi: 10.1093/jat/16.3.147.
    参考文献:10.1016/s0378-4347(96)00259-9
    摘要:Einig T, Dunemann L, Dehnen W. Sensitive gas chromatographic method for determination of mercapturic acids in human urine. Journal of Chromatography B: Biomedical Sciences and Applications. 1996 Dec;687(2):379–85. doi: 10.1016/s0378-4347(96)00259-9.
    参考文献:10.1002/rcm.1580
    摘要:Barbieri A, Sabatini L, Accorsi A, Roda A, Violante FS. Simultaneous determination of t,t ‐muconic, S ‐phenylmercapturic and S ‐benzylmercapturic acids in urine by a rapid and sensitive liquid chromatography/electrospray tandem mass spectrometry method. Rapid Comm Mass Spectrometry. 2004 Jul 30;18(17):1983–8. doi: 10.1002/rcm.1580.
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