CAS: 17467-35-5; 5-Amino-3-Methyl-1,2,4-Thiadiazole

5-氯-3-甲基-1,2,4-噻唑置于氨体系中,用 乙醇 用作溶剂,化学反应生成5-氨基-3-甲基-1,2,4-噻二唑
参考文献:Zbirovsky,M. Et Al.,Collection Of Czechoslovak Chemical Communications,1971,Vol. 36,P. 4091-4098
标题:Zbirovsky,M. Et Al.,Collection Of Czechoslovak Chemical Communications,1971,Vol. 36,P. 4091-4098

专利信息

专利号:US-12162849-B2
优先权日:2018-12-21
标题 :Synthesis of 3-methyl-1,2,4-thiadiazole-5-carbohydrazide or of the methyl-d3 deuterated form thereof
发明人：HOVEYDA HAMID; DUTHEUIL GUILLAUME
权利人:OGEDA SA
摘要:The present invention relates to a method of synthesis of compound (I), wherein R1 represents methyl or methyl-d3, thus corresponding to 3-methyl-1,2,4-thiadiazole-5-carbohydrazide or to the methyl-d3 deuterated form thereof. These compounds are useful as key intermediates in the synthesis of pharmaceutical compounds, especially fezolinetant and deuterated fezolinetant.

专利号:US-5215997-A
优先权日:1985-09-11
标题:Synthesis of beta-lactam compounds
发明人：HUNGERBUEHLER ERNST; KALVODA JAROSLAV
权利人:CIBA GEIGY CORP
摘要:The invention relates to an improved process for the preparation of compounds of formula ##STR1## or salts thereof, starting from compounds of formulae ##STR2## via compounds of formulae ##STR3## in which compounds R 1 is hydrogen or lower alkyl, R 2 is an organic radical which may carry a functional group which may be protected by a customary protective group R 2 o , R 3 is hydrogen or a customary carboxyl protective group R 3 o , W is a group which can be replaced by a thiocarboxylic acid radical of formula III, and Z is oxygen or sulfur.

专利号:US-9006421-B2
优先权日:2013-03-14
标题 :Cephalosporin compositions and methods of manufacture
发明人：LAI JAN-JI; PATHARE PRADIP M; KOLLA LAXMA; SORET ADRIEN F
权利人:CUBIST PHARM INC
摘要:Provided herein is a method for the synthesis of cephalosporin antibiotic compounds comprising the conversion of a protected 7-amino group into a 7-carboxamide moiety in a single step.

专利号:WO-2020128003-A1
优先权日:2018-12-21
标 题 :SYNTHESIS OF 3-METHYL-1,2,4-THIADIAZOLE-5-CARBOHYDRAZIDE OR OF THE METHYL-d3 DEUTERATED FORM THEREOF

专利号:EP-3180347-B1
优先权日:2014-08-15
标 题:Synthesis of cephalosporin compounds

专利号:ES-2950143-T3
优先权日:2018-12-21
标 题 :Synthesis of 3-methyl-1,2,4-thiadiazole-5-carbohydrazide or the deuterated methyl-d3 form of this