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专利信息
专利号:US-2024301453-A1
优先权日:2020-12-21
标题 :Means and methods for manufacturing racemic alanine for the mgda synthesis
发明人:MAITRO-VOGEL SOPHIE; BREUER MICHAEL; TANG DAN-TAM DANIEL; SCHMIDT THOMAS
权利人:BASF SE
摘要:The present invention relates to the field of chemical manufacture. In particular, it relates to a method for manufacturing racemic methylglycinediacetic acid (MGDA) comprising the steps of contacting a solution comprising or being enriched in D-alanine or L-alanine to an alanine racemase at a temperature of at least 50° C. and alkaline conditions for a time sufficient to allow conversion of said solution into a racemic alanine solution, obtaining a racemic alanine solution, and chemically converting the racemic alanine into racemic MGDA. The invention further contemplates an alanine racemase which is capable of converting a solution comprising or being enriched in D-alanine or L-alanine into racemic alanine solution at a temperature of at least 50° C. and under alkaline conditions as well as the use of said alanine racemase for converting a solution comprising or being enriched in D-alanine or L-alanine into racemic alanine solution at a temperature of at least 50° C. and under alkaline conditions.
专利号:WO-2006097348-A1
优先权日:2005-03-15
标 题:Use of agents such as nonpolymeric nitric oxide donors for making the lips full again and/or colouring the lips
发明人:CALS-GRIERSON MARIE-MADELEINE
权利人:OREAL; CALS-GRIERSON MARIE-MADELEINE
摘要:The invention relates in particular to the cosmetic use (i) of at least one agent for promoting the production of NO in and/or on the lips, chosen from nitric oxide NO donors or precursors; nonpolymeric NO releasers; and NO synthase synthesis and/or activity stimulators; or (ii) of other agents for promoting microcirculation in the skin, chosen from potassium channel openers; calcium channel blockers; phosphodiesterase inhibitors; flavonoids; vasodilator peptides that are not NO donors; temperature modulators; agents for promoting the stimulation and/or maintenance of angiogenesis; agents for promoting the stimulation of endothelial cell proliferation; agents for promoting endothelial cell migration; and mixtures thereof, in a makeup and/or care composition for the lips, as an agent for naturally making the lips full again and/or naturally coloring the lips. It also relates to specific care and/or makeup compositions for the lips containing said agent, and also to a cosmetic process aimed at making the lips naturally full and/or colored, using said compositions .
专利号:BR-112017006799-B1
优先权日:2014-10-17
标题 :METHOD OF TREATMENT OF AN UNDERGROUND FORMATION, PROCESS FOR THE SYNTHESIS OF A COMPOUND, AND, SYSTEM FOR CARRYING OUT THE METHOD
专利号:US-9227915-B2
优先权日:2011-05-03
标题 :Process for the preparation of a crystalline L-MGDA trialkali metal salt
发明人:OFTRING ALFRED; WEBER MAXIM; BRAUN GEROLD; LAUTERBACH ARNULF
权利人:OFTRING ALFRED; WEBER MAXIM; BRAUN GEROLD; LAUTERBACH ARNULF; BASF SE
摘要:A process is proposed for the preparation of a crystalline L-MGDA trialkali metal salt by crystallization from an aqueous solution thereof which has been obtained by Strecker synthesis, starting from L-α-alanine, by reaction with formaldehyde and hydrocyanic acid to give L-α-alanine-N,N-diacetonitrile and subsequent alkaline saponification of the L-α-alanine-N,N-diacetonitrile to give the L-MGDA trialkali metal salt, wherein a temperature of 150° C. is not exceeded during the alkaline saponification.
专利号:US-11939363-B2
优先权日:2017-02-28
标题:Translatable molecules and synthesis thereof
发明人:LIMPHONG PATTRARANEE; TACHIKAWA KIYOSHI; CHIVUKULA PADMANABH; MATSUDA DAIKI; CALE ARISA
权利人:ARCTURUS THERAPEUTICS INC
摘要:A range of therapeutic mRNA molecules expressible to provide a target polypeptide or protein. The RNA molecules can contain one or more 5-methoxyuridines and 5-methylcytidines. Further provided are DNA templates, which can be transcribed to provide a target mRNA, and can have altered nucleotides, such as reduced deoxyadenosines. Also provided are processes for making the therapeutic mRNA molecules. The RNA molecules can be translated in vitro or in vivo to provide an active polypeptide or protein. The RNA molecules can be included in a composition used for preventing, treating, or ameliorating at least one symptom of a disease or condition in a subject in need thereof.
专利号:EP-3630985-B1
优先权日:2017-05-31
标题 :Synthesis and structure of high potency rna therapeutics