CAS: 1597403-47-8; N,N'-(Trans-Cyclohexane-1,4-Diyl)Bis(2-(4-Chlorophenoxy)Acetamide)
该化合物是综合应激反应(IRS)路径的一个强大和选择性的小分子抑制器,它有效地逆转eIF2α磷化介介介的转化衰减,在压力条件下恢复蛋白合成; 跨异构体配置确保最佳的结合和生物活动; IRIB表现出高度的特性,其离目标效果最小,使其成为研究细胞应激机制以及...
- 英文名称N,N'-(Trans-Cyclohexane-1,4-Diyl)Bis(2-(4-Chlorophenoxy)Acetamide)
- 中文名称ISRIB(TRANS-ISOMER) 抑制剂
- IUPAC名称N,N'-((1r,4r)-cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide)
- 其它别名Isrib (Trans-Isomer); Trans-N,N'-(Cyclohexane-1,4-Diyl)Bis(2-(4-Chlorophenoxy)Acetamide); N,N'-((1R,4R)-Cyclohexane-1,4-Diyl)Bis(2-(4-Chlorophenoxy)Acetamide) Isrib(Trans-Isomer); Trans-Isrib; Acetamide, N,N'-Trans-1,4-Cyclohexanediylbis[2-(4-Chlorophenoxy)-; N,N'-Trans-1,4-Cyclohexanediylbis[2-(4-Chlorophenoxy)Acetamide]; Isrib - Trans-Isrib
- CAS编号1597403-47-8
- MFCD编号:MFCD27952932
- FDA UNII编号:S6SZR97SBZ
- 分子式:C22H24Cl2N2O4分子量:451.35
- 产品CID: 800616
- 同类组份化合物CAS1597403-47-8 (trans-isomer)548470-11-7
- 产品分类Inhibitors/Agonists → Apoptosis → PERK
物理性质
上下游产品
trans-1,4-cyclohexyldiamine 4-chlorophenyloxyacetyl chloride cis-1,4-cyclohexanediamine合成工艺路线路线简述
海关参考信息
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2908191000-对氯苯酚
2912110000-甲醛
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主要参考文献
1: Xu C, He S, Zhu Y, Crasto G, Chen C, Clay ML, Lao YH, Leong KW. Vascular Organoid Generation from Human-Induced Pluripotent Stem Cells. J Vis Exp. 2024 Dec 13;(214). doi: 10.3791/67125. 1871(1):167562. doi: 10.1016/j.bbadis.2024.167562. Epub 2024 Nov 7. 121(42):e2406009121. doi: 10.1073/pnas.2406009121. Epub 2024 Oct 10.
4: Xu S, Gierisch ME, Barchi E, Poser I, Alberti S, Salomons FA, Dantuma NP. Chemical inhibition of the integrated stress response impairs the ubiquitin- proteasome system. Commun Biol. 2024 Oct 8;7(1):1282. doi: 10.1038/s42003-024-06974-0.
5: Isaac AR, Chauvet MG, Lima-Filho R, Wagner BA, Caroli BG, Leite REP, Suemoto CK, Nunes PV, De Felice FG, Ferreira ST, Lourenco MV. Defective regulation of the eIF2-eIF2B translational axis underlies depressive-like behavior in mice and correlates with major depressive disorder in humans. Transl Psychiatry. 2024 Oct 1;14(1):397. doi: 10.1038/s41398-024-03128-y.
合成参考文献
参考文献:10.1038/cddis.2015.264
摘要:Palam LR, Gore J, Craven KE, Wilson JL, Korc M. Integrated stress response is critical for gemcitabine resistance in pancreatic ductal adenocarcinoma. Cell Death & Disease. 2015 Oct 15;6(10):e1913. doi: 10.1038/cddis.2015.264.
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