CAS: 130405-40-2; (2S,3R)-2-(3,4-Dihydroxyphenyl)-5,7-Dihydroxychroman-3-Yl 3,4,5-Trihydroxybenzoate

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CAS号732298-10-1 (-)-(2S,3R)-5,7... | CAS号63604-98-8 3,5-bis(benzylo... | CAS号1486-48-2 3,4,5-三(苄氧基)苯甲酸 | CAS号1486-47-1 3,4,5-tris(phen... | CAS号732298-08-7 (E)-3-[2,4-bis(... | CAS号87292-50-0 (-)-(2S,3R)-5,7... | CAS号732298-09-8 (-)-(1R,2R)-3-[... | CAS号1257-08-5 表儿茶素没食子酸酯

合成工艺路线路线简述

    (-)-(2S,3R)-5,7-Bis(Benzyloxy)-2-[3,4-Bis(Benzyloxy)Phenyl]Chroman-3-Ol置于palladium Dihydroxide 4-二甲氨基吡啶,氢气体系中,用 四氢呋喃,甲醇,二氯甲烷 用作溶剂,化学反应 6.0H,反应生成儿茶素
    参考文献:Study Of The Green Tea Polyphenols Catechin-3-Gallate (Cg) And Epicatechin-3-Gallate (Ecg) As Proteasome Inhibitors
    标题:Study Of The Green Tea Polyphenols Catechin-3-Gallate (Cg) And Epicatechin-3-Gallate (Ecg) As Proteasome Inhibitors
    摘要:The Green Tea Polyphenol Catechin-3-Gallate (Cg) And Epicatechin-3-Gallate (Ecg) Were Synthesized Enantioselectively Via A Sharpless Hydroxylation Reaction Followed By A Diastereoselective Cyclization. Their Potencies To Inhibit The Proteasome Activity Were Measured. The Unnatural Enantiomers Were Found To Be Equally Potent To The Natural Compounds. (C) 2004 Elsevier Ltd,All Rights Reserved.
    Doi:10.1016/j.Bmc.2004.04.033

    海关参考信息

    专利信息


    专利号:US-2004266699-A1
    优先权日:2001-10-04
    标 题 :Flavonoid compounds capable of modifying the dynamic and/or physical state of biological membranes and to stimulate the endogenous synthesis of stress proteins in eukaryotic cells, relative synthesis and their use
    发明人:PORTA AMALIA
    摘要:The invention relates to flavonoids compounds of formula (I) and (II) capable of modifying the dynamic and/or physical state of biological membranes and to stimulate the endogenous synthesis of stress proteins in eukaryotic cells. Such compounds are molecules of plant origin or synthetic. The invention also describes a method to identify, purify and chemically synthesize such flavonoid compounds and test their efficacy through their capacity to stimulate the transcription of stress genes and as a consequence, to interact with biological membranes with alteration of their relative physical state. Such compounds and corresponding pharmaceutically acceptable derivatives and/or salts have applications in the areas of pharmaceuticals, more specifically in cosmetics and dermatology, for all those afections related to an alteration of the expression of stress genes.

    专利号:US-2009170928-A1
    优先权日:2005-04-28
    标题:Synthesis of oligo/poly(catechins) and methods of use

    专利号:US-5605929-A
    优先权日:1992-05-27
    标题:Methods and compositions for inhibiting 5α-reductase activity
    发明人:LIAO SHUTSUNG; LIANG TEHMING
    权利人:ARCH DEV CORP
    摘要:Disclosed are a novel class of antiandrogenic compounds including saturated and unsaturated fatty acids, catechin gallates, their derivatives, and synthetic analogs, their method of synthesis, and their use in treating disorders associated with androgenic activities. Also disclosed is the use of known compounds not previously known for their antiandrogenic activity in treating disorders related to androgenic activities and cancers.

    专利号:CN-115612114-A
    优先权日:2021-07-14
    标 题:Method and application of copolymer film and its enzymatic self-assembly synthesis
    成都草源康生物科技有限公司
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    主要参考文献

    1. Lamy, S., Gingras, D., and Béliveau, R. Green tea catechins inhibit vascular endothelial growth factor receptor phosphorylation. Cancer Res. 62(2), 381-385 (2002). 2. Sartippour, M.R., Heber, D., Ma, J., et al. Green tea and its catechins inhibit breast cancer xenografts. Nutr. Cancer 40(2), 149-156 (2001). 3. Strobel, P., Allard, C., Perez-Acle, T., et al. Myricetin, quercetin and catechin-gallate inhibit glucose uptake in isolated rat adipocytes. Biochem. J. 386(Pt 3), 471-478 (2005). 4. Paveto, C., Güida, M.C., Esteva, M.I., et al. Anti-Trypanosoma cruzi activity of green tea (Camellia sinensis) catechins. Antimicrob. Agents Chemother. 48(1), 69-74 (2004).

    合成参考文献


    参考文献:10.1016/j.lwt.2009.03.017
    摘要:Yang Z, Tu Y, Baldermann S, Dong F, Xu Y, Watanabe N. Isolation and identification of compounds from the ethanolic extract of flowers of the tea (Camellia sinensis) plant and their contribution to the antioxidant capacity. LWT - Food Science and Technology. 2009 Oct;42(8):1439–43. doi: 10.1016/j.lwt.2009.03.017.
    参考文献:10.1128/aac.00124-07
    摘要:Sharma S, Sharma SK, Modak R, Karmodiya K, Surolia N, Surolia A. Mass spectrometry-based systems approach for identification of inhibitors of Plasmodium falciparum fatty acid synthase. Antimicrob Agents Chemother. 2007 Jul;51(7):2552–8.
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