CAS: 127337-60-4; 2-Chloromethyl-3-Methyl-4-(2,2,2-Trifluoroethoxy)Pyridine Hydrochloride

相似化合物

86604-74-2 128430-66-0 127337-60-4

2,3-二甲基-4-(2,2,2-三氟乙氧基)吡啶-N-氧化物置于氯化亚砜,硫酸,乙酸酐体系中,用 二氯甲烷 用作溶剂,化学反应 9.0H,反应生成2-氯甲基-3-甲基-4-(2,2,2-三氟乙氧基)吡啶盐酸盐
参考文献:N-芳基异硫脲类新型胃h+/k+-Atp酶抑制剂的设计与合成
标题:N-芳基异硫脲类新型胃h+/k+-Atp酶抑制剂的设计与合成
摘要:为了寻找治疗消化性溃疡病的新型 H+/k+-Atpase 抑制剂,合成了一系列新型 N-芳基异硫脲衍生物,并通过 1H NMR 和 Gc-Ms 对其结构进行了鉴定.以泮托拉唑镁作为阳性对照,通过豚鼠胃粘膜研究评价这些化合物抑制胃酸分泌的作用.结果表明,在合成的 37 种 N-芳基异硫脲化合物中,有 20 种化合物具有与泮托拉唑镁相当或更强的胃酸抑制活性.还通过比较分子场分析 (Comfa) 计算研究了 N-芳基异硫脲化合物的定量构效关系 (Qsar),最终预测了应该提供更强大生物活性的模型结构.
Doi:10.1002/ardp.201300276

专利信息

专利号:US-8962851-B2
优先权日:2011-12-27
标题:One-pot process for the preparation of benzimidazole derivatives
发明人：DWIVEDI SHRIPRAKASH DHAR; PRASAD ASHOK; PAL DAYA RAM
权利人:CADILA HEALTHCARE LTD
摘要:The present invention discloses one pot process for enantioselective synthesis of single enantiomers of substituted sulphoxides 2-(2-pyridinylmethylsulphinyl)-1H-benzimidazoles or said compounds in an enantiomerically enriched form.

专利号:US-10111854-B2
优先权日:2014-02-26
标题 :Synthesis and use of amine-containing flavonoids as potent anti-leishmanial agents
发明人：CHOW LARRY MING-CHEUNG; Chan Tak Hang William; CHAN KIN-FAI; WONG IRIS LAI KING; KAN WING-YIU
权利人:UNIV HONG KONG POLYTECHNIC
摘要:The present invention relates to novel series of amine-containing flavonoids and compositions containing the compounds, as well as the synthesis and the use of the same. The invention also relates to methods of treatment and prevention of diseases, in particular, parasitic infections including Leishmaniasis, comprising administration of the compounds.

专利号:CN-112707889-B
优先权日:2020-06-15
标题:A kind of synthesis method of lansoprazole

专利号:RU-2100358-C1
优先权日:1994-02-28
标 题:Derivatives of 5-pyrrolyl-2-pyridylmethylsulfonylbenzimidazole or their salts and a method of their synthesis

专利号:US-2017143665-A1
优先权日:2014-02-26
标题:Synthesis and use of amine-containing flavonoids as potent anti-leishmanial agents

专利号:CN-114853678-A
优先权日:2022-03-31
标 题 :Synthesis method of lansoprazole bulk drug intermediate H-benzimidazole