CAS: 1258-84-0; Pristimerin
该化合物是一种自然形成的三叶虫类化合物,主要来自各种植物来源,特别是Celastraceae家族的植物来源,其特点是复杂的分子结构,包括多个环和功能组,有助于生物活动;Pristimerin展示了多种药理特性,包括防炎,抗癌症和抗寄生虫作用,使其成为医药化学和药理学的课题;该化合物主要来自各种植物来源,特别是癌症和疟疾等疾病的治疗;其行动机制往往涉及各种信号路径的调节和癌症细胞中诱导的流行性硬化.此外,Pristimerin的脂质性质使其能够与细胞膜有效互动,提高生物利用率和功效.随着研究的继续,对Pristimin的全部潜力及其衍生物的探索,可能导致新型治疗剂的发展.
- 英文名称Pristimerin
- 中文名称扁塑藤素
- IUPAC名称methyl (2S,4aS,6aR,12bR,14aR,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylate
- 其它别名pristimerin; 3-Hydroxy-2-oxo-24-nor-DA-friedoolean-1(10),3,5,7-tetren-29-oic acid methyl ester; Celastrol-methylether; (9b,13a,14b,20a)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tertraen-29-oic acid methyl ester; (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oicacidmethylester
- CAS编号1258-84-0
- MFCD编号:MFCD01711331
- FDA UNII编号:28ZK7PR57S
- 分子式:C30H40O4分子量:464.64
- 产品CID: 388842
- 产品分类生物化工 → 提取物
物理性质
MSDS等安全信息
- 警示词warning
- 危险描述H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
- 防范说明P264Thoroughly clean after treatmentP280Wear protective gloves/Wear protective clothing/Wear protective goggles/Wear a protective maskP305If it enters the eyesP351Rinse carefully with water for a few minutesP338Remove the contact lens(If any)And easy to operate,Continue flushingP337If eye irritation persistsP313Obtain medical advice/care
- UN编号NONH for all modes of transport
- 安全声明H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
- WGK Germany3.0
上下游产品
CAS号34157-83-0 雷公藤红素; 南蛇藤素 | CAS号74-88-4 碘甲烷 | CAS号186581-53-3 重氮甲烷合成工艺路线路线简述
📜Methyl (2R,4As,6Ar,6Ar,6Br,14As,14Br)-10,11-Dimethoxy-2,4A,6A,6A,9,14A-Hexamethyl-3,4,5,6,6B,7,8,13,14,14B-Decahydro-1H-Picene-2-Carboxylate置于三乙基硅烷,Lithium Aluminium Tetrahydride,Jones Reagent,苯基氯化硒,Aluminum Tri-Bromide,Palladium 10% On Activated Carbon,氢气,Potassium Carbonate,N,N-二异丙基乙胺,三氟乙酸,Sodium Iodide,Potassium Hydroxide体系中,用 四氢呋喃,1,4-二氧六环,甲醇,乙醚,二氯甲烷,水,乙酸乙酯,丙酮,甲苯,苯 用作溶剂,化学反应 86.83H,反应生成扁塑藤素
参考文献:Total Synthesis Of Celastrol,Development Of A Platform To Access Celastroid Natural Products
标题:Total Synthesis Of Celastrol,Development Of A Platform To Access Celastroid Natural Products
摘要:Celastroid Natural Products,Triterpenes,Have Been And Continue To Be Investigated In Clinical Trials. Celastrol,And For That Matter Any Member Of The Celastroid Family,Was Prepared For The First Time Through Chemical Synthesis Starting From 2,3-Dimethylbutadiene. A Triene Cyclization Precursor Generated In 12 Steps Underwent A Nonbiomimetic Polyene Cyclization Mediated By Ferric Chloride To Generate The Generic Celastroid Pentacyclic Core. In The Cyclization,Engagement Of A Tetrasubstituted Olefin Formed Adjacent All Carbon Quaternary Centers Stereospecifically. With Access To The Carbocydic Core Of The Family Of Natural Products,Wilforic Acid And Wilforol A Were Prepared En Route To Racemic Celastrol.
Doi:10.1021/jacs.5B06261
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2901241000-1,3-丁二烯
2905121000-正丙醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Fu X, Jiao Y, Feng Y, Lin F, Zhang B, Mao Q, Wang J, Jiang W, Mou Y, Wang H, Wang S. Scaffold Hopping of Pristimerin Provides Derivatives Containing a Privileged Quinoxaline Substructure as Potent Autophagy Inducers in Breast Cancer Cells. J Nat Prod. 2024 Aug 23;87(8):1952-1964. doi: 10.1021/acs.jnatprod.4c00373. Epub 2024 Aug 6. 12(2):70. doi: 10.1007/s40203-024-00247-8.
3: Nakano K, Yokota Y, Vu QV, Lagravinese F, Kataoka T. Structure-Activity Relationship of Oleanane-Type Pentacyclic Triterpenoids on Nuclear Factor κB Activation and Intracellular Trafficking and N-Linked Glycosylation of Intercellular Adhesion Molecule-1. Int J Mol Sci. 2024 May 30;25(11):6026. doi: 10.3390/ijms25116026.
4: Wang Y, Chen T, Cong X, Li Y, Chen R, Zhang P, Sun X, Zhao S. [Pristimerin enhances cisplatin-induced apoptosis in nasopharyngeal carcinoma cells via ROS-mediated deactivation of the PI3K/AKT signaling pathway]. Nan Fang Yi Ke Da Xue Xue Bao. 2024 May 20;44(5):904-912. Chinese. doi: 10.12122/j.issn.1673-4254.2024.05.12.
合成参考文献
参考文献:10.3184/030823410x12658949561706
摘要:Chen M, Wang D, Guo J. 3-Oxo-11β-Hydroxyfriedelane from the Roots of Celastrus Monospermus. Journal of Chemical Research. 2010 Feb;34(2):114–7. doi: 10.3184/030823410x12658949561706.
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