CAS: 1115-84-0; (S)-(3-Amino-3-Carboxypropyl)Dimethylsulfonium Chloride

该化合物是一种化合物,对它的潜在健康惠益,特别是胃肠健康,引起了人们的兴趣,它不是传统意义上的维生素,而是往往与消化道中溃疡的治疗和促进愈合有关,该物质是氨基酸甲硫磷的衍生物,其特点是含有硫结构.维生素U是溶水的,通常存在于各种植物来源,特别是卷心菜和其他受难蔬菜中,其生物活动被认为源于其稳定细胞膜和促进某些蛋白质合成的能力.虽然已经研究过其治疗效果,特别是溃疡愈合作用,但需要开展更多的研究才能充分了解其机制和效率.与任何补充一样,在使用之前,必须征求保健专业人员的意见,特别是考虑到与其他药物或条件的潜在互动.

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CAS号63-68-3 L-蛋氨酸 | CAS号74-88-4 碘甲烷 | CAS号75-18-3 二甲基硫 | CAS号672-15-1 L-高丝氨酸

合成工艺路线路线简述

    📜L-蛋氨酸,碘甲烷置于dowex Cl-Form体系中,用 甲醇,水 用作溶剂,化学反应 48.0H,以70%的收率获得维生素 U
    参考文献:双头硫键连接的氨基酸作为甜菜碱-高半胱氨酸s-甲基转移酶2的第一抑制剂
    标题:双头硫键连接的氨基酸作为甜菜碱-高半胱氨酸s-甲基转移酶2的第一抑制剂
    摘要:甜菜碱-高半胱氨酸的s-甲基转移酶2(bhmt-2)催化甲基从s-甲基甲硫氨酸向1-高半胱氨酸的转移,产生两个分子的1-甲硫氨酸.它是哺乳动物中三种同型半胱氨酸甲基转移酶之一,但其对同型半胱氨酸再甲基化和硫氨基酸稳态的总体贡献尚不清楚.而且,重组bhmt-2是高度不稳定的,这减慢了其结构和催化性能的研究.在这项研究中,我们准备了将要描述的第一批bhmt-2抑制剂,并已通过与人重组bhmt共纯化而稳定的人重组bhmt-2对其进行了测试.在合成的化合物中,(2 S,8Rs,11 Rs)-5-硫杂-2,11-二氨基-8-甲基十二烷二酸(11)是最有效的(k I App约为77 Nm)和bhmt-2的选择性抑制剂.化合物11仅弱抑制人bhmt(ic 50约为77μm ).该化合物(11)可用于将来的体内研究中,以探测bhmt-2在硫氨基酸代谢中的生理意义.
    Doi:10.1021/jm300571H

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    专利信息


    专利号:US-5922335-A
    优先权日:1995-05-15
    标 题:Uses for ascorbyl-phosphoryl-cholesterol in topical compositions
    发明人：PTCHELINTSEV DMITRI
    权利人:AVON PROD INC
    摘要:Novel uses of 3'-(L-ascorbyl-2-o-phosphoryl)-cholesterol, 3'-(L-ascorbyl-3-o-phosphoryl)-cholesterol, structural or functional isomers thereof and salts thereof (referred to collectively as 'APC compounds') are disclosed. Such novel uses include a method of reducing epidermal synthesis of abnormal elastin, especially epidermal synthesis of abnormal elastin that results from exposure to UV radiation. Also disclosed is a novel method of stimulating keratinocyte formation of triglycerides. In addition, a novel method of achieving antioxidant activity, both in the skin and also in topical compositions, is disclosed.

    专利号:US-8927485-B2
    优先权日:2010-02-18
    标题:Site-specific modification of proteins through chemical modification enabling protein conjugates, protein dimer formation, and stapled peptides
    发明人：KRANTZ ALEXANDER; YU PENG
    权利人:KRANTZ ALEXANDER; YU PENG; ADVANCED PROTEOME THERAPEUTICS INC
    摘要:The present invention generally provides methods for the site-specific modification of peptides, polypeptides, and proteins, e.g., granulocyte macrophage colony-stimulating factor, human superoxide dismutase, annexin, leptin, antibodies and the like, cytokines and chemokines, at their N-termini and at sites at which unnatural aminoacids have been introduced along the protein framework. The modifications described herein can be used for the synthesis and application of the adducts in radio-labeling, molecular imaging and protein therapeutic applications, and the treatment of disorders such as rheumatoid arthritis, lupus erythematosus, psoriasis, multiple sclerosis, type-1 diabetes, Crohn's disease, and systemic sclerosis, Alzheimer disease, cancer, liver disease (e.g., alcoholic liver disease), and cachexia.

    专利号:RU-2387671-C1
    优先权日:2008-07-30
    标 题 :Method for synthesis of cross-linked salt of hyaluronic acid, modified with vitamines

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    主要参考文献


    1: Oktay S, Bayrak G, Alev B, Ipekci H, Ustundag UV, Turkyilmaz IB, Pisiriciler R, Emekli-Alturfan E, Tunali-Akbay T, Yanardag R, Yarat A. The effect of vitamin U on the lung tissue of pentyleneterazole-induced seizures in rats. Naunyn Schmiedebergs Arch Pharmacol. 2018 Feb;391(2):177-184. doi: 10.1007/s00210-017-1447-3. Epub 2017 Dec 7. doi: 10.1104/pp.17.00579. Epub 2017 May 23.
    3: Cohen H, Salmon A, Tietel Z, Hacham Y, Amir R. The relative contribution of genes operating in the S-methylmethionine cycle to methionine metabolism in Arabidopsis seeds. Plant Cell Rep. 2017 May;36(5):731-743. doi: 10.1007/s00299-017-2124-1. Epub 2017 Mar 13. doi: 10.4062/biomolther.2016.254.
    5: Song JH, Lee HR, Shim SM. Determination of S-methyl-L-methionine (SMM) from Brassicaceae Family Vegetables and Characterization of the Intestinal Transport of SMM by Caco-2 Cells. J Food Sci. 2017 Jan;82(1):36-43. doi: 10.1111/1750-3841.13556. Epub 2016 Nov 24. Review. Russian. doi: 10.1039/c5fo01258a. doi: 10.3390/ijms160817088.

    合成参考文献


    摘要:Matsuo T, Seri K, Kato T. Comparative effects of S-methylmethionine (vitamin U) and methionine on choline-deficient fatty liver in rats. Arzneimittelforschung. 1980;30(1):68–9.
    摘要:Matsuo T, Seri K, Kato T. A possible activation of cholesterol 7-hydroxylation by S-methylmethionine (vitamin U). Arzneimittelforschung. 1980;30(2):258–9.
    参考文献:10.1136/gut.39.1.77
    摘要:Roediger WE, Babidge W, Millard S. Methionine derivatives diminish sulphide damage to colonocytes--implications for ulcerative colitis. Gut. 1996 Jul;39(1):77–81.
    摘要:STREHLER E. [Contribution to the knowledge of the ulcer-preventive factor (so-called vitamin U) intestinal activity of vitamin U-containing dry extracts of cabbage. II]. Hippokrates. 1958 Oct 15;29(19):629–33.
    摘要:SZABO Z, VARGHA G. [Histological effect of vitamin U on ulcers induced on the stomach of dogs]. Kiserl Orvostud. 1958 Apr;10(2-3):200–6.
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