专利号:WO-2021250635-A1 优先权日:2020-06-11 标题:Acid salts of fluoroquinolone carboxylic acid based compositions and methods of making and using the same 发明人:GHOSH SUMANA; BHATTACHARYYA ANAMIKA; SINGH HIMANSHI; SADHASIVAM SURESH; SINHA MAU; GARG MUKESH KUMAR; GARKHAL KALPNA; KUMAR MUKESH; KHARE PRAGATI; GUPTA SWATI; SENGUPTA SHILADITYA; CHAVDARIAN CHARLES G 权利人:VYOME THERAPEUTICS INC 摘要:The present disclosure is in the field of pharmaceutical and chemical sciences. The present disclosure generally relates to the synthesis of therapeutic agents, processes for preparing said agents, compositions comprising said therapeutic agents and their uses. In particular, the disclosure relates to medicinally important acid salts of fluoroquinolone carboxylic acid based chemical molecules [compounds of formula (I)], method of preparing said molecules, compositions thereof, and the use of such molecules as therapeutic agents. The said acid salts of fluoroquinolone carboxylic acid based chemical molecules are useful in treating infections such as ear infections, otitis, otitis media including acute otitis media, recurrent otitis media, otitis media with effusion, chronic otitis media, chronic suppurative otitis media, otitis externa (including acute otitis externa, chronic otitis externa), otitis interna and combinations thereof.
专利号:WO-2020158831-A1 优先权日:2019-01-30 标 题:Transdermal absorption composition with controlled release of water-soluble hydrochloride 发明人:ONO FUMIYASU; GOTO MASAHIRO 权利人:UNIV KYUSHU NAT UNIV CORP; NISSAN CHEMICAL CORP 摘要:The objective of the present invention is to provide a method for simply raising the transdermal absorption properties of a water-soluble hydrochloride without forming a prodrug by organic synthesis. The present invention relates to: a composition containing a water-soluble hydrochloride and a liposoluble compound having an aldehyde group; a transdermal absorption composition containing said composition, a transdermal absorption control agent, and a liposoluble medium; and a method for controlling the release of the water-soluble hydrochloride from the composition into the skin.
专利号:WO-2020226482-A1 优先权日:2019-05-09 标题:Synergistic compositions for controlling plant pathogens with chitinolytic microorganisms / organic acid combinations and method of use thereof 发明人:LAI HONG HENG 权利人:LAI HONG HENG 摘要:The present invention relates to pesticidal compositions and methods for controlling plant pathogens, particularly basal stem rot in the oil palm primarily caused by Ganoderma species. The pesticidal compositions comprising, as active components: (A) Bioactive compound derived from a whole broth culture of an chitinolyic microorganisms, wherein the bioactive compound comprises any or any combination of: chitinolyic microorganism, whole cell broths, liquid cultures, spores, pure cultures, cell fraction, substances, suspensions, supernatants, filtrates, extract or a cell-free extract thereof or metabolite thereof or isolated compounds, wherein the bioactive compound is derived from at least one chitinolyic microorganisms that degrade chitinous substrates. The said chitinolytic microorganism is bacteria belonging to genus Bacillus, Streptomyces and/or fungal genus Trichoderma; (B) at least one organic acid; and (C) at least one pesticide selected from chemical pesticides, microbial pesticides, plant defense activators, cuticle degrading enzymes, cell wall synthesis inhibitors, bacteriocins, antifungal peptides, antimicrobial preservatives, plant oil or plant extract. More specifically, this invention envisions the use of bioactive compounds and/or metabolites from chitinolyic microorganisms in combination essentially of organic acid and the compositions comprising them, in the use form as fungicides and/or insecticides, also be present as 'booster' to other pesticides results in many cases in an expension of pesticidal spectrum of activity or in a prevention of pesticide resistance development. Furthermore, in many cases, synergistic effects are obtained. In various embodiments, the organic acid consists essentially of acetic acid, preferably acetic acid from a fermentation. The formulation is typically applied to agricultural soil or plant material. In a particular, the present invention can be used in combination with a carrier selected from the plant growth nutrient, organic fertilizer or inorganic/organic mixture fertilizer. Although the following description relates almost exclusively to managing basal stem rot (BSR) disease in oil palm primarily caused by Gonoderma species. It will be appreciated by those skill in the art that the invention could be used to treat other diseases and pests of other plants, includes but is not limited to a fungus, bacteria, actinomycete, virus, insects, Acari and/or nematodes.
专利号:EP-0486510-B1 优先权日:1989-08-08 标 题:Cyclic amidocarboxy surfactants, synthesis and use thereof 发明人:GOZE JEAN M; BERNHARDT RANDAL J; HARTLAGE JAMES A; SMITH NORMAN R; LIETZ DENNIS E; KAY JAMES W; BREITBEIL FRED W; SAJIC BRANCO; ROCKWELL NED MILES; MCCONNELL NINA MONTSERRAT; MOHRING WILLIAM RICHARD 权利人:STEPAN CO 摘要:Cyclic amidocarboxy surfactants having general formula (I) wherein: R1 and R2 are independently selected from the group consisting essentially of H or C1-C40 linear or branched, substituted or unsubsituted alkyl, cycloalkyl, alkylene, alkaryl, aryl or R3-O-R4 groups, with R3 and R4 being independently selected from the group consisting essentially of C1-C22 linear or branched, substituted or unsubstituted alkyl, cycloalkyl, alkylene, alkaryl and aryl groups; y is an integer of a value satisfying the valency of M; and M is a cation and is preferably selected from the groups consisting of H, Na, K, NH4 [including (CH3CH2)3NH, (CH3CH2)2NH2, (HOCH2CH2)3NH, (HOCH2CH2)2NH2 and similar ammonium derivatives], Ba, Ca, Mg, Al, Ti, Zr and mixtures thereof. These surfactants are useful in a variety of technical applications, such as fast-break emulsifiers in personal care products; destructible latex polymerization surfactants in manufacture and compounding of various coating or adhesive systems; domestic fabric softening agents; foodstuff emulsifiers; caustic-stabile surfactants; bleach-stabile surfactants; various domestic detergents and hard surface cleaners, emulsifiers for portland cement and concrete; floatation/benefication agents for mining/processing various mineral ores; additives for electroplating and/or surface finishing for metal goods; additives for plaster, gypsum and miscellaneous building materials; enhanced oil recovery additives; wetting and lubricating agents for industrial textile processing; compatibilizers/surfactants for polyurethane/isocyanurate foam systems, wood pulping additives; emulsifiers for various industrial surfactant systems, such as fatty alcohol/water emulsions; pour-point depressants for transporting petroleum crude oils, suspension agents for various particulate materials, such as anti-dandruff materials, i.e., sulfur, zinc pyrithone, etc. and other particulate materials, such as pulverized coal, and other similar uses.
专利号:US-10695394-B2 优先权日:2013-05-30 标题:Composition containing herbal medicine extracts of Pinellia and Scutellaria for reducing side effects due to anticancer drugs 发明人:RYU HEON MO; KIM DAE JUN; BYUN JOON SEOK; SOHN KI CHEUL; KU SAE KWANG 权利人:COMPREHENSIVE AND INTEGRATIVE MEDICINE INST 摘要:The present invention relates to a composition containing a Pinelliae Rhizoma and Scutellariae Radix extract as an active ingredient to reduce side effects caused by an anticancer drug, and more particularly, a composition for reducing side effects such as damage to the gastrointestinal tract and a gastrointestinal motility disorder by administering an anticancer drug. The composition of the present invention has an excellent effect of reducing side effects in administration of the anticancer drug through an antioxidative function, and synthesis, secretion and control of the functions of gastrin and serotonin producing gastrointestinal endocrine cells.
专利号:CA-2640585-A1 优先权日:2003-02-05 标题 :Synthesis of 2-butyl-3-(2'-(1-trityl-1h-tetrazol-5-yl)biphenyl-4-yl)-1,3-diazaspirol{4,4}-non-ene-4-one
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