CAS: 10329-98-3; N-((2S,3R,4R,5S,6R)-4,5-Dihydroxy-6-(Hydroxymethyl)-2-(Naphthalen-1-Yloxy)Tetrahydro-2H-Pyran-3-yl)Acetamide

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📜2-乙酰氨基-3,4,6-三-O-乙酰-2-脱氧-α-D-吡喃葡萄糖酰基氯置于sodium Hydroxide,四丁基溴化铵,Sodium Methylate体系中,用 甲醇,二氯甲烷 用作溶剂,化学反应 1.83H,反应生成1-萘基-N-乙酰基-Beta-D-氨基葡萄糖苷
参考文献:Design Of N-Acetyl-6-Sulfo-β-D-Glucosaminide-Based Inhibitors Of Influenza Virus Sialidase
标题:Design Of N-Acetyl-6-Sulfo-β-D-Glucosaminide-Based Inhibitors Of Influenza Virus Sialidase
摘要:Biological Activity Of N-Acetyl-6-Suifo-Beta-D-Glucosaminides (6-Sulfo-Glcnac 1) Having A Structural Homology To N-Acetylneuraminic Acid (Neu5Ac 2) And 2-Deoxy-2,3-Dehydro-N-Acetylneuraminic Acid (Neu5Ac2En 3) Was Examined In Terms Of Inhibitory Activity Against Influenza Virus Sialidase (Influenza,A/memphis/l/71 H3N2). Pnp 6-Sulfo-Glcnac La Was Proved To Show Substantial Activity To Inhibit The Virus Sialidase Ic50 2.8 Mm),Though P-Nitrophenyl (Pnp) Glcnac Without 6-Sulfo Group And Pnp 6-Sulfo-Glcnh(3)(+) 1B Without 2-Nhac Showed Little Activity Ic50 > 50 Mm). The Activity Was Enhanced Nearly 100-Fold When The Pnp Group Of La Was Converted To P-Acetamidophenyl One 5 (Ic50 = 30 Mum) Or Replaced With 1-Naphthyl 6 Ic50 = 10 Mum) Or N-Propyl One 8 (Ic50 = 11 Mum) (C) 2004 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmc.2004.01.013