CAS: 100-14-1; P-Nitrobenzyl Chloride

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CAS号619-73-8 对硝基苯甲醇 | CAS号100-44-7 氯化苄 | CAS号104-03-0 对硝基苯乙酸 | CAS号191097-22-0 2-(2-tert-butyl... | CAS号99-99-0 对硝基甲苯 | CAS号555-16-8 对硝基苯甲醛 | CAS号14856-73-6 (4-Nitrobenzyl)... | CAS号3145-86-6 P-NITROBENZYL IODIDE | CAS号500-11-8 1-(fluoromethyl... | CAS号110270-80-9 (4-Nitrobenzyl)... | CAS号5440-67-5 Benzene,1-(2-me... | CAS号1012-18-6 1-(2-methylprop... | CAS号107108-25-8 2-methyl-4-nitr... | CAS号105804-72-6 3-methyl-2-(3-m... | CAS号555-21-5 4-硝基苯乙腈 | CAS号414880-35-6 1-乙基-4-(4-硝基苯)哌嗪 | CAS号4403-71-8 4-氨基苄胺 | CAS号586-91-4 偶氮苯-4,4-二羧酸 | CAS号582-69-4 氧化偶氮苯-4,4’-二羧酸

4-硝基甲苯置于盐酸,四丁基氯化铵,Sodium Chloride体系中,用 水 用作溶剂,以93%的收率获得1-(氯甲基)-4-硝基苯
参考文献:Nanoag @ Agcl在可见光诱导下用无机氯化物对炔烃进行α-H氯化反应
标题:Nanoag @ Agcl在可见光诱导下用无机氯化物对炔烃进行α-H氯化反应
摘要:已开发出一种以nacl / Hcl为氯源的烷基芳烃α-H基团的有效光催化氯化方法,该方法涉及可见光(包括日光)条件下的自由基机理.提出了通过电子从氯离子到空气中通过半导体agcl的带隙孔转移到o 2形成氯自由基的方法.氯化方案的特点是使用自然阳光或其他可见光,温和的条件,廉价的氯气源,绿色溶剂和高选择性.苄基氯的收率为95%,甲苯转化率高达40%,可与传统的氯化方法相媲美.
Doi:10.1002/chem.201501439

专利信息

专利号:US-8822702-B2
优先权日:2002-12-20
标 题 :Synthesis of amines and intermediates for the synthesis thereof
发明人：BERENS ULRICH; DOSENBACH OLIVER; SPRENGER DANIEL
权利人:BERENS ULRICH; DOSENBACH OLIVER; SPRENGER DANIEL; BASF SE
摘要:The invention relates in a first embodiment to a method for the manufacture of esters of the formula I, n nor especially of amides of the formula II,n n nwherein the symbols have the meanings given in the specification, as well as other intermediates and compounds useful in the synthesis of tryptamines and other substances mentioned in the title. The synthesis methods and intermediates are useful in the synthesis of pharmaceuticals.

专利号:EP-0791575-A1
优先权日:1996-02-16
标题 :Method of synthesis of a quaternary ammonium salt
发明人：NAKANO SHINJI
权利人:NIPPON PAINT CO LTD
摘要:The present invention provides an improved method of synthesis of a quaternary ammonium salt in which a tertiary amine is reacted with a benzyl halide optionally having on the benzene ring and/or at the α-site one ore more substituent groups inert to the reaction, which method is characterized in that the reaction is carried out in water or in a water-containing organic solvent.

专利号:US-7786156-B2
优先权日:2004-01-28
标 题 :Synthesis methods and intermediates for the manufacture of Rizatriptan
发明人：MARTIN PIERRE; BERENS ULRICH; BOUDIER ANDREAS; DOSENBACH OLIVER
权利人:RATIOPHARM GMBH
摘要:The invention relates to a process for the manufacture of an 1,2,4-triazol-1-yl compound of the formula [A], n nor a salt thereof, wherein each of R3 and R4 is hydrogen or lower alkyl, said process comprising reacting a hydrazine compound of the formula [B]n n nwherein R is hydrogen or acyl, R2 is hydrogen or a protecting group, are hydrogen or lower alkyl, and R6 is hydrogen or COOR7, or a salt thereof, with a 1,2,4-triazolyl forming reagent.n n In addition, novel intermediates for the synthesis of the anti-migraine agent Rizatriptan and methods for their synthesis are presented.

专利号:US-8309695-B2
优先权日:2007-06-11
标题 :Marking reagents bearing diazo and nitro functions, methods for the synthesis of such reagents and methods for detecting biological molecules
发明人：LAURENT ALAIN; LAAYOUN ALI; KOTERA MITSUHARU
权利人:LAURENT ALAIN; LAAYOUN ALI; KOTERA MITSUHARU; BIOMERIEUX SA; CENTRE NAT RECH SCIENT; UNIV STRASBOURG
摘要:The present invention relates to a labeling reagent of formula: n nin which:n R 1 represents at least one detectable label, L and A are each a linker arm, n is an integer equal to 1, and u is an integer between 0 and 2.n nThe present invention also describes a method of synthesizing said markers and also applications for the labeling of biological molecules, more particularly nucleic acids, with a labeling reagent bearing diazo and nitro functions. The invention is particularly suitable for use in the diagnostics field.

专利号:US-3886180-A
优先权日:1973-03-15
标 题:Process for the synthesis of N-hydroxypyrroles
发明人：ABRAMOVITCH RUDOLPH ABRAHAM; CUE JR BERKELEY WENDELL
权利人:ABRAMOVITCH RUDOLPH ABRAHAM; CUE JR BERKELEY WENDELL
摘要:A process is described for the preparation of N-hydroxypyrrole2-carbonitriles, N-hydroxyimidazole-2-carbonitriles, pyrrole-2carbonitriles, and 3-substituted-2, 3-dihydro-2-pyrrolones by thermally decomposing 2-azidoheteroaromatic N-oxides. In the process a 2-azidoheteroaromatic N-oxide is heated in a suitable solvent for a period of time sufficient to bring the reaction to completion. Removal of the solvent by conventional methods gives the desired product. Which product is obtained is determined by the choice of solvents. In non-polar aprotic solvents, Nhydroxypyrrole-2-carbonitriles or N-hydroxyimidazole-2carbonitriles are obtained. In nucleophilic solvents capable of undergoing Michael-type additions pyrrole-2-carbonitriles, imidazole-2-carbonitriles, and 3-substituted-2,3-dihydro-2pyrrolone derivatives are obtained where a solvent molecule comprises the 3-substituent. These compounds are useful as antibaterials, e.g., against E. Coli.

专利号:US-4006160-A
优先权日:1973-03-15
标题:Process for the synthesis of N-hydroxypyrroles, N-hydroxyimidazoles, and derivatives thereof
发明人：ABRAMOVITCH RUDOLPH ABRAHAM; CUE JR BERKELEY WENDELL
权利人:UNIV ALABAMA
摘要:A process is described for the preparation of N-hydroxypyrrole-2-carbonitriles, N-hydroxyimidazole-2-carbonitriles, pyrrole-2-carbonitriles, and 3-substituted-2, 3-dihydro-2-pyrrolones by thermally decomposing 2-azidoheteroaromatic N-oxides. In the process a 2-azidoheteroaromatic N-oxide is heated in a suitable solvent for a period of time sufficient to bring the reaction to completion. Removal of the solvent by conventional methods gives the desired product. Which product is obtained is determined by the choice of solvents. In non-polar aprotic solvents, N-hydroxypyrrole-2-carbonitriles or N-hydroxyimidazole-2-carbonitriles are obtained. In nucleophilic solvents capable of undergoing Michael-type additions pyrrole-2-carbonitriles, imidazole-2-carbonitriles, and 3-substituted-2,3-dihydro-2-pyrrolone derivatives are obtained where a solvent molecule comprises the 3-substituent. These compounds are useful as anti-bacterials, e.g., against E. Coli.