CAS: 99-96-7; 4-Hydroxybenzoic Acid

上下游产品

CAS号623-05-2 对羟基苯甲醇 | CAS号586-76-5 对溴苯甲酸 | CAS号619-58-9 对碘苯甲酸 | CAS号14047-29-1 4-羧基苯硼酸 | CAS号1927-95-3 4-溴乙酸苯酯 | CAS号124-38-9 二氧化碳 | CAS号619-42-1 对溴苯甲酸甲酯 | CAS号86960-46-5 4-Decanoyloxy b... | CAS号56-23-5 四氯化碳 | CAS号108-95-2 苯酚 | CAS号110929-34-5 (4-methoxypheny... | CAS号106924-13-4 6,8-dibromo-2-m... | CAS号111833-05-7 4-(4-hexylbenzo... | CAS号106924-06-5 2-methyl-3-[[2-... | CAS号1076199-77-3 rac-5-羧基托特罗定 | CAS号110846-17-8 5-hydroxy-2-[(4... | CAS号111973-84-3 (4-heptylphenyl... | CAS号106047-17-0 4-(吡啶-4-基)苯甲酸甲酯 | CAS号5216-25-1 对氯三氯甲苯 | CAS号104-93-8 4-甲基苯甲醚(MSO)

对氨基苯甲酸置于硫酸,Sodium Nitrite体系中,用 水 作为反应溶剂,以96%的收率获得产物对羟基苯甲酸
参考文献:使用两相系统(cpme 和水)水解重氮盐
标题:使用两相系统(cpme 和水)水解重氮盐
摘要:开发了一种不形成焦油的重氮盐水解新方法.由环戊基甲基醚 (Cpme) 和水组成的两相系统对于重氮盐的水解非常有效.使用该溶剂系统,由 3-(4-硝基苯氧基)苯胺制备的重氮盐在 20 分钟内以高产率 (96%) 得到 3-(4-硝基苯氧基)苯酚.合成的苯酚是工业上合成聚合物的重要原料.此外,使用本 Cpme 和水的两相系统成功地将几种间位取代苯胺有效转化为相应的间位取代苯酚.这是使用两相系统(cpme 和水)水解重氮盐的第一个例子.
DOI:10.1002/hc.21275

专利信息

专利号:US-7589170-B1
优先权日:1998-09-25
标题 :Synthesis of cyclic peptides
发明人：SMYTHE MARK LESLIE; MEUTERMANS WIM DENIS FRANS; BOURNE GREGORY THOMAS; MCGEARY ROSS PETER
权利人:UNIV QUEENSLAND
摘要:This invention relates to methods for preparing cyclic peptides and peptidomimetic compounds in solution and bound to solid supports, and to cyclic peptide or peptidomimetic libraries for use in drug screening programs. In particular, the invention relates to a generic strategy for synthesis of cyclic peptides or peptidomimetics that enables the efficient synthesis under mild conditions of a wide variety of desired compounds. Two approaches were evaluated for their improvements in solution and solid phase synthesis of small cyclic peptides: positioning reversible N-amide substituents in the sequence; and applying native ligation chemistry in an intramolecular sense. Systematic investigation of the effects of preorganising peptides prior to cyclisation by using peptide cyclisation auxiliaries, and developing new linkers and peptide cyclisation auxiliaries to aid cyclic peptide synthesis gives surprising improvements in both yields and purity of products compared to the prior art methods. The combination of these technologies provides a powerful generic approach for the solution and solid phase synthesis of small cyclic peptides. The ring contraction and N-amide substitution technology of the invention provide improved methods for the synthesis of cyclic peptides and peptidomimetics. When used in conjunction with linker strategies, this combination provides solid-phase avenues to cyclic peptides and peptidomimetics.

专利号:US-6063919-A
优先权日:1998-08-14
标题:Process for the synthesis of exochelins
发明人：GAUDIOSO LARRY A; WEGLARZ MICHAEL A
权利人:KEYSTONE BIOMEDICAL INC
摘要:A process for the synthesis of an Exochelin comprising the steps of generating L-N-[(2-benzyloxy-(benzoyl)] serine or L-N-[2-benzyloxy (benzoyl)] threonine, creating L-N-t-Boc- epsilon -hydroxynorleucine and reacting same to produce L-N-Boc- epsilon -bromonorleucine trimethylsilylethyl ester, providing a dicarboxylic acid and forming an O-benzyl methyl hydroxamate from the dicarboxylic acid, coupling the O-benzyl methyl hydroxamate with the L-N-Boc- epsilon -bromonorleucine trimethylsilylethyl ester to give an L-N2-Boc-N6-methyl,N6-(benzyloxy) lysine 2-trimethylsilylethyl ester which incorporates the dicarboxylic acid as modified above, removing the N-tert-butoxycarbonyl protecting group from the L-N2-Boc-N6-methyl, N6-(benzyloxy) lysine 2-trimethylsilylethyl ester to yield a substituted lysine, and coupling the same with the L-N-[2-benzyloxy (benzoyl) serine or -threonine to yield a 2-trimethyl silylethyl ester of dibenzyl Exochelic acid, transforming the 2-trimethyl silylethyl ester of dibenzyl Exochelic acid to dibenzyl Exochelic acid, preparing benzyl epi-cobactin, forming an ester bond between the dibenzyl Exochelic acid and benzyl epi-cobactin to form an intermediate, and, hydrogenolytically removing three benzyl groups from said intermediate, resulting in the synthesized Exochelin. More particularly, a synthesis for Exochelin 786SM (R) is disclosed wherein the dicarboxylic acid is suberic acid and the serine form is utilized.

专利号:US-9433605-B2
优先权日:2006-03-23
标 题 :Method for promoting synthesis of tissue collagen
发明人：KAMIYA TOSHIKAZU; KAMIMURA AYAKO; KAWADA YOKO
权利人:KYOWA HAKKO BIO CO LTD
摘要:An object of the present invention is to provide an oral preparation for promoting synthesis of tissue collagen, an oral preparation for promoting healing of skin wounds or an oral preparation for preventing or improving skin wrinkles or sagging, which is safe and has an excellent effect. The present invention can provide an oral preparation for promoting synthesis of tissue collagen, an oral preparation for promoting healing of skin wounds or an oral preparation for preventing or improving skin wrinkles or sagging, which comprises hydroxyproline or a salt thereof as an active ingredient.

专利号:WO-2017080770-A1
优先权日:2015-11-10
标题 :Synthesis of (z)-endoxifen hydrochloride
发明人：HEINKELE GEORG; MUERDTER THOMAS; SCHWAB MATTHIAS
权利人:ROBERT BOSCH GES FÃœR MEDIZINISCHE FORSCHUNG MBH
摘要:The invention relates to the synthesis of tamoxifen, endoxifen and derivatives thereof. Starting from a substituted benzoic acid derivative and 2-phenoxyethyl halide, the intermediate product of general formula (I) is obtained. The compound of general formula (VI) or a salt thereof is obtained from the compound of general formula (I), via isomer purification of the compound of general formula (I) by obtaining the (Z)-isomers and reacting the (Z)-isomers with an amine of formula HNR 6 R 7 . Alternatively, the compound of general formula (I) is reacted with a compound of formula HNR 6 R 7 , and the amine thus obtained is then subjected to isomer purification, wherein the compound of general formula (VI) or a salt thereof is obtained.

专利号:US-10604479-B2
优先权日:2013-11-18
标 题:Continuous process for the one-pot synthesis of metal salts and metal complexes
发明人：LEONARDI GIULIANO; GASPERONI GIOVANNI
权利人:VOLARE & CONNECTING LLC; LEONARDI GIULIANO; NOVUS INT INC
摘要:A continuous process is described for the one-pot synthesis of compounds, such as metal salts and metal complexes, as well as optionally for the protection of the compounds thus obtained by coating and/or impregnation with suitable compounds.

专利号:US-5405949-A
优先权日:1993-03-29
标题 :Process for the synthesis of glycosaminoglycans with heparin or heparan structure modified in position 2 of the α-L-iduronic-2-O-sulfate acid
发明人：UNGARELLI FABRIZIO; PIANI SILVANO
权利人:ALFA WASSERMANN SPA
摘要:A process for the synthesis of glycosaminoglycans with heparin or heparan structure modified in position 2 of the α-L-iduronic-2-O-sulfate acid in which the sulfate group is, entirely or in part, substituted with a nucleophilic group, is described. The process is carried out by treating glycosaminoglycans having heparin or heparan structure with a nucleophilic reagent in alkaline solution.