专利号:US-5143583-A 优先权日:1991-04-02 标 题:Preparation and synthesis of magnetic fibers 发明人:MARCHESSAULT ROBERT H; RIOUX PATRICE; RICARD SERGE 权利人:MARCHESSAULT ROBERT H; RIOUX PATRICE; RICARD SERGE 摘要:Magnetic paper-forming fibers have a particulate magnetic material incorporated within the fibers, as distinct from between the fibers; this can be achieved by loading the lumens of cellulosic fibers with magnetic particles or by generating magnetic particles in situ in a paper-forming fiber which contains ionic groups effective for ion exchange with ferrous ions; the fibers can be employed to produce single layer or multi-layererd magnetic papers for information storage, security paper applications, paper handling, reprographic applications such as magnetographic printing substrate as well as for speciality uses such as electromagnetic shielding, magnetic separation of antibodies based on selective adsorption.
专利号:US-12208068-B2 优先权日:2013-12-31 标题:Amphetamine controlled release, prodrug, and abuse-deterrent dosage forms 发明人:POPP KARL; MECKLER HAROLD 权利人:PHARMAPOTHECA A INC 摘要:The invention also relates to processes for producing abuse deterrent pharmaceutical compositions comprising highly pure amphetamine and amphetamine-class compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds, and to methods of manufacturing, delivering, and using the amphetamine compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds.
专利号:US-5935946-A 优先权日:1997-07-25 标 题 :Nucleotide analog composition and synthesis method 发明人:MUNGER JR JOHN D; ROHLOFF JOHN C; SCHULTZE LISA M 权利人:GILEAD SCIENCES INC 摘要:The invention provides a composition comprising bis(POC)PMPA and fumaric acid (1:1). The composition is useful as an intermediate for the preparation of antiviral compounds, or is useful for administration to patients for antiviral therapy or prophylaxis. The composition is particularly useful when administered orally. The invention also provides methods to make PMPA and intermediates in PMPA synthesis. Embodiments include lithium t-butoxide, 9-(2-hydroxypropyl) adenine and diethyl p-toluenesulfonylmethoxyphosphonate in an organic solvent such as DMF. The reaction results in diethyl PMPA preparations containing an improved by-product profile compared to diethyl PMPA made by prior methods.
专利号:EP-0998480-B1 优先权日:1997-07-25 标 题:Nucleotide analog composition and synthesis method 发明人:MUNGER JOHN D JR; ROHLOFF JOHN C; SCHULTZE LISA M 权利人:GILEAD SCIENCES INC 摘要:The invention provides a composition comprising bis(POC)PMPA and fumaric acid (1:1). The composition is useful as an intermediate for the preparation of antiviral compounds, or is useful for administration to patients for antiviral therapy or prophylaxis. The composition is particularly useful when administered orally. The invention also provides methods to make PMPA and intermediates in PMPA synthesis. Embodiments include lithium t-butoxide, 9-(2-hydroxypropyl) adenine and diethyl p-toluenesulfonylmethoxy-phosphonate in an organic solvent such as DMF. The reaction results in diethyl PMPA preparations containing an improved by-product profile compared to diethyl PMPA made by prior methods.
专利号:US-6451340-B1 优先权日:1997-07-25 标题:Nucleotide analog compositions 发明人:ARIMILLI MURTY N; KELLY DAPHNE E; LEE THOMAS T K; MANES LAWRENCE V; MUNGER JR JOHN D; PRISBE ERNEST J; SCHULTZE LISA M 权利人:GILEAD SCIENCES INC 摘要:The invention provides crystalline forms of adefovir dipivoxil and methods to prepare the crystals. The compositions and methods of the present invention have desirable properties for large scale synthesis of crystalline adefovir dipivoxil or for its formulation into therapeutic dosages. Invention compositions include an anhydrous crystal form of adefovir dipivoxil.
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