CAS: 83-25-0; N-Phenylsuccinimide

该化合物是一种环环有机化合物,其特点是1位的苯基组取代了1-二,5-二酮核心,这种结构在合成化学中具有反活性作用,特别是在合成药品,农用化学品和特殊材料时作为前体或中间体;其环状的二氧化二氮为功能化提供场所,允许多种衍生途径;苯基组增强稳定性和影响电子特性,使其在设计生物活性分子时具有价值;该化合物通常用于研究和工业应用,需要受控地修改丙醇-2,5-二硝基骨架;由于在特定条件下可能发生再活动,建议适当处理.

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CAS号110-15-6 琥珀酸； 丁二酸 | CAS号98-95-3 硝基苯 | CAS号102-14-7 4-氧代-4-(苯氨基)丁酸 | CAS号123-56-8 丁二酰亚胺 | CAS号98-80-6 苯硼酸 | CAS号108-30-5 丁二酸酐 | CAS号941-69-5 N-苯基马来酰亚胺 | CAS号603-33-8 三苯基铋 | CAS号591-50-4 碘苯 | CAS号4096-21-3 1-苯基吡咯烷 | CAS号3563-14-2 磺胺琥珀酸 | CAS号100-01-6 对硝基苯胺 | CAS号4641-57-0 1-苯基-2-吡咯烷酮 | CAS号29879-80-9 5-Hydroxy-5-met... | CAS号23132-35-6 4-oxo-N-phenylp... | CAS号18377-52-1 1-(2-nitropheny... | CAS号35488-92-7 N-(4-NITROPHENY... | CAS号97-02-9 2,4-二硝基苯胺 | CAS号83-24-9 2,5-二甲基-1-苯基吡咯

合成工艺路线路线简述

    📜4-Hydroxy-N-Phenylbutanamide置于potassium Permanganate,Sodium Hydroxide体系中,用 水 作为反应溶剂,以96%的收率获得产物n-苯丁二醯亞胺
    参考文献:内酯有机催化开环氨解法无金属合成n-芳基酰胺
    标题:内酯有机催化开环氨解法无金属合成n-芳基酰胺
    摘要:生物来源的非应变内酯与芳族胺的催化开环可以提供一种直接的,100%原子经济且可持续的通往相关n芳基酰胺支架的途径.在此,据报道,在温和的操作条件下,使用有机双环胍催化剂,由反应性较差的芳族胺和非应变的内酯首次形成了无金属且高效的n-芳基酰胺.该协议具有很高的应用潜力,例如与药物相关的分子的形式合成.
    DOI:10.1002/cssc.201700415

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    专利信息


    专利号:US-2005182260-A1
    优先权日:2002-05-18
    标 题:Process for the preparation of cyclic imides in the presence of polyphosphoric acid
    发明人：MEDERSKI WERNER; BAUMGARTH MANFRED; GERMANN MARTINA; KUX DIETER; WEITZEL THOMAS
    摘要:The present invention relates to a novel process for the preparation of N-substituted cyclic imides. N-substituted cyclic imides are valuable intermediates which can be employed, for example, for the synthesis of pharmacologically valuable compounds.

    专利号:US-2016101414-A1
    优先权日:2013-05-15
    标 题 :Highly z-selective and enantioselective ring opening/cross metathesis catalyzed by a resolved stereogenic-at-ru complex
    发明人：HARTUNG JOHN; GRUBBS ROBERT H
    权利人:CALIFORNIA INST OF TECHN
    摘要:This invention relates generally to enantiomerically enriched C—H activated ruthenium olefin metathesis catalyst compounds which are stereogenic at ruthenium, to the preparation of such compounds, and the use of such catalysts in the metathesis of olefins and olefin compounds, more particularly, in the use of such catalysts in enantio- and Z-selective olefin metathesis reactions. The invention has utility in the fields of catalysis, organic synthesis, polymer chemistry, and industrial and fine chemicals chemistry.

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    主要参考文献

    参考标题:Synthesis Of Lactams By Regioselective Reduction Of Cyclic Dicarboximides
    作者:Maria J. Milewska,Tomasz Bytner,Tadeusz Połoński |发布日期:1996.12
    摘要:Lactams Can Be Obtained By The Monothionation Of Imides With Lawesson'S Reagent Followed By The Desulfurization Of Resulted Monothioimides With Raney Nickel.

    合成参考文献


    摘要:Nieto, C. T.; Eames, J.; Garrido, N. M., Science of Synthesis Knowledge Updates, (2019) 1, 122.
    摘要:Li, H.; Wang, Y.; Liu, Q., Science of Synthesis: Base-Metal Catalysis, (2023) 2, 551.
    参考文献:10.1016/j.bmcl.2010.01.098
    摘要:Jha A, Mukherjee C, Prasad AK, Parmar VS, Vadaparti M, Das U, De Clercq E, Balzarini J, Stables JP, Shrivastav A, Sharma RK, Dimmock JR. Derivatives of aryl amines containing the cytotoxic 1,4-dioxo-2-butenyl pharmacophore. Bioorganic & Medicinal Chemistry Letters. 2010 Mar;20(5):1510–5. doi: 10.1016/j.bmcl.2010.01.098.
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