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CAS号6908-41-4 4-(羟基甲基)苯甲酸甲酯 | CAS号151-50-8 氰化钾 | CAS号2417-72-3 4-溴甲基苯甲酸甲酯 | CAS号143-33-9 氰化钠 | CAS号7677-24-9 三甲基氰硅烷 | CAS号60-29-7 乙醚 | CAS号34040-64-7 4-氯甲基苯甲酸甲酯 | CAS号99-75-2 对甲基苯甲酸甲酯 | CAS号124-63-0 甲基磺酰氯 | CAS号773837-37-9 sodium cyanide | CAS号52787-14-1 4-甲酸甲酯苯乙酸甲酯 | CAS号50685-26-2 4-(氰甲基)苯甲酸 | CAS号444667-11-2 4-(羧基甲基)-3-硝基苯甲酸 | CAS号501-89-3 4-羧基苯乙酸 | CAS号83799-24-0 非索芬那定 | CAS号64353-30-6 [4-(2-氨基-乙基)-苯基]-甲醇 | CAS号77265-67-9 4-(2-氨基乙基)-苯甲酸甲酯 | CAS号334952-07-7 4-(2-甲氧基-2-氧代乙基... | CAS号73928-05-9 4-Stilbenecarbo... | CAS号64353-37-3 4-(2-aminoethyl...

对甲基苯甲酸甲酯置于n-溴代丁二酰亚胺(Nbs),四丁基碘化铵,过氧化苯甲酰体系中,用 四氯化碳,乙腈 作为反应溶剂,化学反应生成 对氰基甲基苯甲酸甲酯
参考文献:钯催化,苄基腈,芳基温瑞布酰胺和苯胺的邻位选择性c-h卤化反应
标题:钯催化,苄基腈,芳基温瑞布酰胺和苯胺的邻位选择性c-h卤化反应
摘要:本文报道了钯催化的邻位选择性c-h卤化方法.这项工作的重点是在存在活化的c(sp 3)-H键的情况下对苄腈进行高选择性的c(sp 2)-H官能化,这将导致卤代产物的非常好收率和极好的区域选择性.与苄基腈一起,已经评估了使用非质子条件转化的芳基weinreb酰胺和苯胺化物的转化率.机理研究在反应途径和指导小组能力方面产生了有趣的方面.
DOI:10.1021/acs.Joc.6B02731

专利信息

专利号:US-6531477-B1
优先权日:1998-10-13
标 题:6-substituted pyrazolo [3,4-d] pyrimidin-4-ones useful as cyclin dependent kinase inhibitors
发明人：MARKWALDER JAY A; SEITZ STEVEN P; SHERK SUSAN R
权利人:DU PONT PHARM CO
摘要:The present invention relates to the synthesis of a novel class of pyrazolo[3,4-d]pyrimidin-4-ones of formula (I), alternatively represented by the tautomer (II):that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cyclin dependent kinase 1-8 and their regulatory subunits know as cyclins A-H, K, N, and T.This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

专利号:US-6559152-B2
优先权日:1998-10-13
标 题 :6-substituted pyrazolo[3,4-d]pyrimidin-4-ones useful as cyclin dependent kinase inhibitors
发明人：MARKWALDER JAY A; SEITZ STEVEN P; SHERK SUSAN R
权利人:DU PONT PHARM CO
摘要:The present invention relates to the synthesis of a novel class of pyrazolo[3,4-d]pyrimidin-4-ones of formula (I), alternatively represented by the tautomer (II):that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cyclin dependent kinase 1-8 and their regulatory subunits know as cyclins A-H, K, N, and T.This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.