CAS: 74472-38-1; 2,3,4,4',6-Pentachlorobiphenyl
该化合物是多氯联苯(PCB)家族的成员,这些合成有机化学品以其环境持久性和潜在毒性而著称,该化合物由两个相连的苯环组成,其中五个氯原子被替换在联苯结构的特定位置上,其物理特性包括水中的高熔点和低溶解性,使其在有机溶剂中更易溶解.多氯原子的存在有助于其稳定性和抗降解性,这引起了人们对环境中生物累积性以及对人类和野生生物的潜在健康影响的关切.多氯联苯,包括2,3,4,4',6-五溴二苯醚,都与各种不良健康影响有关,包括内分泌干扰和致癌性.由于这些特点,许多国家对多氯联苯的生产和使用进行了严格的管制或禁止.环境监测和补救工作对于管理与这种物质和其他多氯联苯同系物相关的风险至关重要.
- 相似结构搜索
- 产品信息参考
;;;; - InChIKey: IOVARPVVZDOPGQ-UHFFFAOYSA-N
- 1S/C12H5Cl5/c13-7-3-1-6(2-4-7)10-8(14)5-9(15)11(16)12(10)17/h1-5H
- 计算化学: 氢键受体数*氢键供体数*可旋转键数1.0
MSDS等安全信息
- 危险描述Not Classified
Reported as not meeting GHS hazard criteria by 3 of 3 companies. For more detailed information, please visit ECHA C&L website. - 安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)
合成工艺路线路线简述
海关参考信息
- 2903911000-邻二氯苯
- 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
摘要:T14: Lewis RJ (1996). Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold.
摘要:L4: ATSDR - Agency for Toxic Substances and Disease Registry (2000). Toxicological profile for polychlorinated biphenyls. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
摘要:L134: ATSDR - Agency for Toxic Substances and Disease Registry (2001). Minimal Risk Levels (MRLs) for Hazardous Substances. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
摘要:L135: International Agency for Research on Cancer (2014). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans.
摘要:T6: World Health Organization (1993). Environ Health Criteria 140: Polychlorniated Biphenyls and Terphenyls.
📝 需求与反馈
尽可能描述清楚需求与问题信息
