硼酸置于丙醇体系中,用 苯 作为反应溶剂,化学反应生成 硼酸三丙酯 参考文献:Catalyseurs Pour La Transformation De Polydiméthylsilanes En Polycarbosilanes 标题:Catalyseurs Pour La Transformation De Polydiméthylsilanes En Polycarbosilanes 摘要: DOI:10.1016/0022-328X(88)89069-7
专利号:US-6642367-B2 优先权日:1995-03-06 标 题:Process for the synthesis of 2′-O-substituted pyrimidines and oligomeric compounds therefrom 发明人:COOK PHILLIP DAN; SANGHVI YOGESH S; SPRANKLE KELLY G; ROSS BRUCE S; GRIFFEY RICH H; SPRINGER ROBERT H 权利人:ISIS PHARMACEUTICALS INC 摘要:Oligonucleotide analogs are disclosed having pyrimidine monomeric sub-units therein that are modified at the 2′ and 5′ positions. Monomeric sub-units having these modifications may be further modified at the 2′ position. Improved processes for the synthesis of 2′-O-substituted pyrimidine nucleosides are also provided. The processes feature alkylation of a 2,2′-anhydropyrimidine nucleoside or a 2S,2′-anhydropyrimidine nucleoside with a weak nucleophile in the presence of a Lewis acid.
专利号:US-8633321-B2 优先权日:2009-09-24 标 题 :Synthesis of (4-fluoro-3-piperidin-4-yl-benzyl)-carbamic acid tert-butyl ester and intermediates thereof 发明人:CHOY NAKYEN; SHAY JR JOHN J; SLEDESKI ADAM W 权利人:CHOY NAKYEN; SHAY JR JOHN J; SLEDESKI ADAM W; SANOFI AVENTIS US LLC 摘要:The present invention is an improved method for the preparation of (4-fluoro-3-pyridin-4-yl-benzyl)-carbamic acid tert-butyl ester, compound of formula I. The invention is directed to a method of synthesis for the compound of formula I in three steps, comprising formation of 5-((tert-butoxycarbonyl)aminomethyl)-2-fluorobenzeneboronic acid (compound 11), reaction of compound 11 under Suzuki coupling conditions to yield (4-fluoro-2-pyridin-4-yl-benzyl)-carbamic acid tert-butyl ester and selective hydrogenation of the aforementioned product under hydrogenation conditions yields compound I. The invention is also directed to the intermediates 5-((tert-butoxycarbonyl)amino-methyl)-2-fluorobenzeneboronic acid (compound 11), and (4-fluoro-3-pyridin-4-yl-benzyl)-carbamic acid tert-butyl ester (compound 13).
专利号:US-6448419-B1 优先权日:2001-08-07 标题:Synthesis of 2-hydroxyestradiol derivatives 发明人:PAAREN HERBERT E; DUFF STEVEN R 权利人:TETRIONICS INC 摘要:Disclosed is a method of preparing 2-hydroxy-3,17β-estradiol derivatives wherein 3,17β-estradiol is reacted with an organolithium reagent and reacted with either a boron reagent or a silicon reagent to form either a 2-boronyl or a 2-silyl modified estradiol analog represented by the corresponding structural formulae: n R 1 and R 2 are each independently a hydroxyl protecting group. R 3 , R 4 and R 5 are selected from the group consisting of halogens, alkyl, aryl, hydroxy, substituted or unsubstituted alkyl, and substituted or unsubstituted aryl.
专利号:WO-2025124974-A1 优先权日:2023-12-11 标题:Synthesis of fumed nanostructured lithium borate powder 发明人:TAKATA Ryo; SCHMIDT FRANZ; SCHÄFER DURDU; WIEGAND ARMIN; HEINDL NICO; KANEEDA MASANOBU; ESKEN DANIEL; HERZOG MARCEL; KANNO RYOJI; NOMOTO KUNIHARU 权利人:EVONIK OPERATIONS GMBH 摘要:A method for making fumed lithium borate, the method comprising: preparing a solution of a lithium precursor, preferably a lithium carboxylate containing 5 to 20 carbon atoms, and a boron source, preferably an organic boron compound, feeding the solution to a flame burning in a flame reaction zone to produce a fumed product comprising fumed lithium borate particles; and obtaining the fumed product.
专利号:US-6107508-A 优先权日:1998-04-03 标 题 :Convergent synthesis of α-aryl-β-ketonitriles 发明人:ZHOU JIACHENG; OH LYNETTE MAY; MA PHILIP 权利人:DU PONT PHARM CO 摘要:The present invention relates to processes for the production of alpha -aryl- beta -ketonitriles, which serve as synthetic intermediates in the preparation of a series of biologically important molecules such as corticotropin releasing factor (CRF) receptor antagonists.
专利号:US-7112679-B2 优先权日:1998-04-03 标题:Convergent synthesis of α-aryl-β-ketonitriles 发明人:ZHOU JIACHENG; OH LYNETTE MAY; MA PHILIP 权利人:BRISTOL MYERS SQUIBB PHARMA CO 摘要:The present invention relates to processes for the production of α-aryl-β-ketonitriles, which serve as synthetic intermediates in the preparation of a series of biologically important molecules such as corticotropin releasing factor (CRF) receptor antagonists.