CAS: 62-31-7; 3-Hydroxytyramine Hydrochloride

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CAS号1699-54-3 3,4-二苄氧基-反-β-硝基苯乙烯 | CAS号120-20-7 3,4-二甲氧基苯乙胺 | CAS号37034-31-4 tert-butyl N-[2... | CAS号93-17-4 3,4-二甲氧基苯乙腈 | CAS号105955-13-3 N-[2-(3,4-dihyd... | CAS号105955-12-2 N-linoleoyldopamine | CAS号105955-10-0 STEARDA | CAS号105955-11-1 N-油酰多巴胺(ODA) | CAS号51-61-6 多巴胺 | CAS号201610-44-8 N-[2-(3,4-二羟基苯基... | CAS号21581-49-7 4-(2-aminoethyl... | CAS号2494-12-4 N-acetyldopamine | CAS号10597-60-1 3,4-二羟基苯乙醇 | CAS号102-32-9 3,4-二羟基苯乙酸

2-(3,4-二羟基苯基)乙胺 氢溴酸盐置于盐酸体系中,用 异丙醇 作为反应溶剂,化学反应 1.0H,以90.6%的收率获得产物盐酸多巴胺
参考文献:一种盐酸多巴胺的合成方法
标题:一种盐酸多巴胺的合成方法
摘要:本发明提供了一种盐酸多巴胺的合成方法,属于药物合成领域.本发明以3,4‑二甲氧基苯乙胺为起始原料,先与酸反应成盐,重结晶精制得到3,4‑二甲氧基苯乙胺盐,与氢溴酸反应脱去甲基,反应生成多巴胺氢溴酸盐,最后与盐酸反应成盐得到盐酸多巴胺.本发明提供的制备方法起始原料廉价易得,工艺简单,无高温高压氢化步骤,成本低,纯度,收率高,适用于工业化生产.

专利信息

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-2024132430-A1
优先权日:2021-08-05
标 题 :Chemicals and use of hypohalites in mechanism-based selective dual radical organic synthesis
发明人：PALOMINO EDUARDO
权利人:WALKER CANCER RES INSTITUTE INC
摘要:The synthesis of pattern-specific compounds using hypohalites, such as hypochlorous acid, sodium hypochlorite, and potassium hypoiodite, as dual-radical generators is provided. The synthesis can be implemented by a cyclization reaction, a dehydrogenation reaction, a hydroxylation reaction, a decarboxylation reaction, or any combination of the above four. The reactions are typically carried out in water, in a nonpolar solvent such as ethyl acetate, or a mixture of both. Hypochlorous acid is made by adding a weak acid such as acetic acid to sodium hypochlorite.

专利号:US-2004053355-A1
优先权日:2000-05-26
标题:Modular approach to on-line synthesis, drug discovery and biochemical transformations using immobilized enzyme reactors
发明人：WAINER IRVING; MARKOGLOU NEKTARIA
摘要:A coupled system using extremely different enzymes with incompatible cofactors and reaction conditions has been constructed using standard liquid chromatographic formats and open tubular formats. One of the significant aspects of the present invention lies in the development of the liquid chromatographic on-line enzyme cascade. This has been illustrated by the biosynthetic pathway involving dopamine beta-hydroxylase and phenylethanolamine N-methyltransferase which encompass the synthesis of the key neurotransmitters, norepinephrine and epinephrine. The results demonstrate for the first time the immobilization of dopamine beta-hydroxylase and phenylethanolamine N-methyltransferase. The IMERs are active and can be used in a liquid chromatographic format for qualitative and quantitative determinations. The IMER-HPLC system can be used to carry out standard Michaelis-Menten enzyme kinetic studies and to quantitatively determine enzyme kinetic constants, identify specific enzyme inhibitors, provide information regarding the mode of inhibition and the inhibitor constants (K i ). A second significant aspect of the present invention lies in the ability of the immobilized enzyme reactors to be used independently or as a combination, thus providing a unique opportunity to explore the interrelationships between these enzymes, to investigate the source of diseases and to design new drug entities for identified clinical syndromes.

专利号:WO-2025128098-A1
优先权日:2023-12-13
标 题 :Solid oral dosage forms, kits, and methods of using the same
发明人：LI YING; LANGER ROBERT; TRAVERSO CARLO
权利人:MASSACHUSETTS INST TECHNOLOGY; BRIGHAM & WOMENS HOSPITAL INC
摘要:Provided herein are solid oral dosage forms, methods, and kits useful, e.g, for the extension of the residence time of active pharmaceutical agents in vivo by the synthesis of a polymer in situ in a subject. In particular, the solid oral dosage forms, methods, and kits disclosed herein are particularly useful for drugs that require more than once daily administration (e.g, drugs that have short half-lives).

专利号:US-2024052097-A1
优先权日:2021-02-08
标题 :Synthesis of peg-based thiol-norbornene hydrogels with tunable hydroylitic degradation properties
发明人：LIN CHIEN-CHI; LIN FANG-YI
权利人:UNIV INDIANA TRUSTEES
摘要:Methods for synthesizing a hydrogel having tunable hydrolylic degradation kinetics according to certain embodiments include synthesizing a norborene-functionalized polyethylene glycol macromer having an ester linkage between a polyethylene glycol domain of the macromer and a norbornene domain of the macromer and having a carboxyl group on the norbornene; and reacting a quantity of such macromers with a quantity of dithiol molecules by an ultraviolet-initiated photo-gelation reaction to yield a hydrogel. Such macromers and such hydrogels form additional aspects of the disclosure, as do a wide variety of methods for tuning and for using such hydrogels.

专利号:US-3903077-A
优先权日:1973-04-05
标题:Direct synthesis of dopamine amino acid amides
发明人：JONES PETER HADLEY; OURS CARROLL WAYNE; ROTEMAN ROBERT
权利人:ABBOTT LAB
摘要:An improved process for synthesizing amino acid amides of dopamine comprising reacting an active ester of an appropriate Ncarbobenzyloxy amino acid directly with a dopamine salt. The amino acid amides of dopamine are useful as renal vasodilators and antihypertensive agents.