CAS: 610-97-9; Methyl 2-Iodobenzoate

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CAS号67-56-1 甲醇 | CAS号88-67-5 邻碘苯甲酸 | CAS号93-58-3 苯甲酸甲酯 | CAS号74-88-4 碘甲烷 | CAS号693232-15-4 2-(methoxycarbo... | CAS号134-20-3 邻氨基苯甲酸甲酯 | CAS号61985-23-7 甲基1H-咪唑-1-羧酸甲酯 | CAS号1225463-02-4 2-iodo-N-methox... | CAS号616-38-6 碳酸二甲酯 | CAS号3240-34-4 碘苯二乙酸 | CAS号105986-52-5 methyl 2-(3-eth... | CAS号88-67-5 邻碘苯甲酸 | CAS号112239-00-6 2-碘-5-硝基苯甲酸甲酯 | CAS号107942-87-0 2-(4-acetylphen... | CAS号1077-79-8 2-乙酰基苯甲酸甲酯 | CAS号107793-07-7 METHYL 2-((TRIM... | CAS号106047-16-9 methyl 2-pyridi... | CAS号606-45-1 2-甲氧基苯甲酸甲酯

苯甲酸甲酯置于2,2,6,6-四甲基哌啶,正丁基锂,Cadmium(II) Chloride-N,N,N',N'-Tetramethylethylenediamine,碘体系中,用 四氢呋喃,正己烷 作为反应溶剂,以89%的收率获得产物2-碘苯甲酸甲酯
参考文献:使用混合的锂-镉,锂-铟和锂-锌物种的功能化芳香剂的去质子化金属化
标题:使用混合的锂-镉,锂-铟和锂-锌物种的功能化芳香剂的去质子化金属化
摘要:在cdcl原位混合物2 ⋅tmeda;(0.5当量tmeda = ñ,ñ,N',N'四甲基乙二胺)或的incl 3与[李(tmp)](tmp = 2,2,6,6(0.33当量)-Tetramethylpiperidino;分别为1.5或1.3当量,)与氯化锌的前述混合物进行了比较2 ⋅tmeda(0.5当量),用于他们的能力去质子苯甲醚,苯并噻唑,和嘧啶和[李(tmp)](1.5当量).[(tmp)3当在室温下用于四氢呋喃中时,Cdli]被证明是最好的碱,随后用碘进行捕集证明了这一点.然后证明了cd-Li碱适用于多种芳族化合物的金属化,包括带有反应性官能团的苯(conet 2,Co 2 Me,Cn,Coph)或重卤素(br,I)和杂环(来自呋喃),噻吩,吡咯,恶唑,噻唑,吡啶和二嗪系列).得益于双重激活位置的五元杂环在室温下也被双去质子化.由此获得的芳族碳酸钙可参与钯催化的交叉偶联反应,或简单地用酰氯淬灭.
DOI:10.1002/chem.200901432

专利信息

专利号:US-12098126-B2
优先权日:2021-08-23
标题:Methods of iron catalyzed C-H bond amination
发明人：CHE CHI-MING; YOU TINGJIE
权利人:VERSITECH LTD; LABORATORY FOR SYNTHETIC CHEMISTRY AND CHEMICAL BIOLOGY LTD
摘要:Described herein is an iron(II)-phthalocyanine catalyzed C—H bond amination of alkyl azides. The catalyst is effective to produce intramolecular amination of saturated C—H bonds in moderate to excellent yields and the methods are tolerant of a wide scope of substrates. The methods described are useful for the synthesis of natural products derivatives and for the late-stage functionalization of pharmaceuticals.

专利号:US-8076496-B2
优先权日:2000-03-16
标题:Chemoselective ligation
发明人：SAXON ELIANA; BERTOZZI CAROLYN RUTH
权利人:SAXON ELIANA; BERTOZZI CAROLYN RUTH; UNIV CALIFORNIA
摘要:The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amide bond between the two reactive partners resulting in a final product comprising a phosphine moiety, or which can be engineered to comprise a cleavable linker so that a substituent of the phosphine is transferred to the azide, releasing an oxidized phosphine byproduct and producing a native amide bond in the final product. The selectivity of the reaction and its compatibility with aqueous environments provides for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).

专利号:WO-0009116-A1
优先权日:1998-08-14
标 题:Grp receptor ligands
发明人：XIANG JIA-NING; KARPINSKI JOSEPH M; CHRISTENSEN SIEGFRIED B IV
权利人:SMITHKLINE BEECHAM CORP; XIANG JIA NING; KARPINSKI JOSEPH M; CHRISTENSEN SIEGFRIED B IV
摘要:Novel GRP receptor antagonists are provided. Methods of using the present compounds to antagonize GRP receptors are also provided. The present invention further involves the synthesis of the present compounds.

专利号:US-9156840-B2
优先权日:2010-06-18
标题:D2 antagonists, methods of synthesis and methods of use
发明人：LUEHR GARY W; SUNDARAM ARATHI; JAISHANKAR PRIYADARSHINI; PAYNE PHILIP W; DRUZGALA PASCAL
权利人:ALTOS THERAPEUTICS LLC
摘要:Provided are D 2 or D 3 antagonist compounds and pharmaceutical compositions of formula I n nand pharmaceutically acceptable salts thereof, or isomers thereof, wherein R 1 , R 2 and R 3 are as defined herein. The invention further comprises methods for making the compounds of the invention and methods for the treatment of conditions mediated by the dopamine D 2 or D 3 receptor from the compounds of the invention.

专利号:US-8399680-B2
优先权日:2007-09-28
标 题:Arylamine synthesis method
发明人：TAILLEFER MARC; XIA NING
权利人:TAILLEFER MARC; XIA NING; CENTRE NAT RECH SCIENT
摘要:The invention relates to a method for preparing arylamines and, in particular, a method for preparing aniline and anilines substituted on the aromatic ring from ammonia, under easily-industrialized mild conditions with good selectivity and yields, in the presence of a catalytic system including a copper complex.

专利号:RU-2178785-C2
优先权日:1996-10-18
标题:Method of synthesis of n-[2-(dimethylamino)-ethyl]-acridine-4- - carboxamide and its derivatives