CAS: 59997-51-2; 4,4-Dimethyl-3-Oxopentanenitrile

相似化合物

29509-06-6 29509-04-4 96798-17-3

上下游产品

CAS号598-98-1 特戊酸甲酯 | CAS号75-05-8 乙腈 | CAS号75-97-8 频那酮 | CAS号13547-70-1 一氯频哪酮 | CAS号773837-37-9 sodium cyanide | CAS号5469-26-1 1-溴频哪酮 | CAS号3282-30-2 特戊酰氯 | CAS号372-09-8 氰基乙酸 | CAS号3938-95-2 特戊酸乙酯 | CAS号1132-15-6 3,5-di(tert-but... | CAS号55809-36-4 3-氨基-5-叔丁基异噁唑 | CAS号75914-61-3 3-(1,1-DIMETHYL... | CAS号136320-07-5 N-(3-tert-butyl... | CAS号192578-76-0 6-tert-butyl-2-... | CAS号227623-29-2 5-叔丁基-2-(吡啶-4-基... | CAS号237435-98-2 3-氨基-5-(叔丁基)-1H... | CAS号82560-12-1 3-氨基-5-叔丁基吡唑 | CAS号285984-25-0 5-叔丁基-2-对甲苯基-2H... | CAS号285983-48-4 多马莫德

频哪酮置于盐酸,Sodium Hydroxide,碳酸氢钠,氯体系中,用 甲醇,水,苯 作为反应溶剂,以85%的收率获得产物新戊酰基乙腈
参考文献:Process For The Production Of Cyanopinacolone
标题:Process For The Production Of Cyanopinacolone
摘要:氰基品酮是通过将品酮与甲醇中约1.0至约1.2摩尔当量的氯反应,然后将产生的单氯基品酮与甲醇中约1.0至约1.2摩尔当量的碱金属氰化物反应而制得的.

专利信息

专利号:US-9708317-B2
优先权日:2013-11-25
标 题 :Process for the preparation of 8-(4-aminophenoxy)-4H-pyrido[2,3-B]pyrazin-3-one derivatives
发明人：ZAMBON ALFONSO; NICULESCU-DUVAZ DAN; CHUBB RICHARD; SPRINGER CAROLINE JOY
权利人:CANCER RES TECH LTD; INST OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (THE); OXY SCIENT LTD; THE INST OF CANCER RESEARCH: ROYAL CANCER HOSPITAL
摘要:The present invention pertains generally to the field of organic chemical synthesis, and in particular to certain methods for the synthesis of 8-(4-aminophenyoxy)-4H-pyrido[2,3-b]pyrazin-3-one and related compounds (denoted herein as (3)) from 4-(4-aminophenyoxy)pyridine-2,3-diamine and related compounds (denoted herein as (1)), by reaction with glyoxylic acid (denoted herein as (2)). The compounds (3) are useful in the synthesis of known anti-cancer agents, such as 1-(5-tert-butyl-2-(4-methyl-phenyl)-pyrazol-3-yl)-3-[2-fluoro-4-[(3-oxo-4H-pyrido[2,3-b]pyrazin-8-yl)oxy]phenyl]urea.

专利号:US-12006337-B2
优先权日:2018-05-30
标题:Mitogen-activated protein kinase inhibitors, methods of making, and methods of use thereof
发明人：HOLTZMAN MICHAEL J; ROMERO ARTHUR G; GEROVAC BENJAMIN J; HAN ZHENFU; KEELER SHAMUS P; WU KANGYUN; ZHANG YONG
权利人:WASHINGTON UNIVERSITY ST LOUIS
摘要:Compounds that inhibit mitogen-activated protein kinases (MAPKs) are disclosed. Some inhibitor compounds specifically target a single MAPK such as MAPK13, while others target multiple MAPKs such as MAPK13 and MAPK12. The compounds can be used therapeutically for a variety of diseases, including cancer and respiratory diseases. Methods of synthesis of the compounds are also disclosed.

专利号:US-7897762-B2
优先权日:2006-09-14
标 题:Kinase inhibitors useful for the treatment of proliferative diseases
发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
权利人:DECIPHERA PHARMACEUTICALS LLC
摘要:The present invention relates to novel kinase inhibitors and modulator compounds useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

专利号:US-8188113-B2
优先权日:2006-09-14
标 题 :Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
权利人:FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C; DECIPHERA PHARMACEUTICALS INC
摘要:The present invention relates to novel dihydropyridopyrimidinyl, dihydronaphthyridinyl, and related compounds which are kinase inhibitors and modulator useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

专利号:US-9790206-B2
优先权日:2013-02-27
标 题:Intermediates for use in the preparation of indazole derivatives and processes for the preparation thereof
发明人：EARY C TODD; HACHE BRUNO P; JUENGST DERRICK; SPENCER STACEY RENEE; STENGEL PETER J; WATSON DANIEL JOHN
权利人:ARRAY BIOPHARMA INC
摘要:Provided herein are novel processes for preparing a compound of Formula (I) to the use of said compound as an intermediate in novel processes for the synthesis of indazole derivatives, and to indazole intermediates and derivatives prepared by the processes described herein.

专利号:US-6894173-B2
优先权日:1999-07-09
标 题 :Intermediates useful for synthesis of heteroaryl-substituted urea compounds, and processes of making same
发明人：ZHANG LIN-HUA; ZHU LEI
权利人:BOEHRINGER INGELHEIM PHARMA
摘要:Disclosed are novel processes and novel intermediate compounds for preparing aryl-and heteroaryl-substituted urea compounds of the formula(I) wherein Ar 1 , Ar 2 , L, Q and X are described herein. The product compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases.